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BMC Cancer
Published in: BMC Cancer 1/2010

Open Access 01-12-2010 | Research article

Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study

Authors: Monique M Cherrier, Paul R Borghesani, Amy L Shelton, Celestia S Higano

Published in: BMC Cancer | Issue 1/2010

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Abstract

Background

A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.

Methods

In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals.

Results

ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation.

Conclusions

Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
Appendix
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Literature
1.
Grubb RL, Kibel AS: Prostate cancer: screening, diagnosis and management in 2007. Missouri medicine. 2007, 104 (5): 408-413. quiz 413-404PubMed
2.
Higano C: Androgen deprivation therapy: monitoring and managing the complications. Hematol Oncol Clin North Am. 2006, 20 (4): 909-923. 10.1016/j.hoc.2006.03.013.CrossRefPubMed
3.
Holmes L, Chan W, Jiang Z, Du XL: Effectiveness of androgen deprivation therapy in prolonging survival of older men treated for locoregional prostate cancer. Prostate Cancer Prostatic Dis. 2007, 10 (4): 388-395. 10.1038/sj.pcan.4500973.CrossRefPubMed
4.
Grossfeld GD, Stier DM, Flanders SC, Henning JM, Schonfeld W, Warolin K, Carroll PR: Use of second treatment following definitive local therapy for prostate cancer: data from the caPSURE database. J Urol. 1998, 160 (4): 1398-1404. 10.1016/S0022-5347(01)62548-5.CrossRefPubMed
5.
Stoch SA, Parker RA, Chen L, Bubley G, Ko YJ, Vincelette A, Greenspan SL: Bone loss in men with prostate cancer treated with gonadotropin- releasing hormone agonists. J Clin Endocrinol Metab. 2001, 86 (6): 2787-2791. 10.1210/jc.86.6.2787.PubMed
6.
Higano C, Shields A, Wood N, Brown J, Tangen C: Bone mineral density in patients with prostate cancer without bone metastases treated with intermittent androgen suppression. Urology. 2004, 64 (6): 1182-1186. 10.1016/j.urology.2004.07.019.CrossRefPubMed
7.
Keating NL, O'Malley AJ, Smith MR: Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol. 2006, 24 (27): 4448-4456. 10.1200/JCO.2006.06.2497.CrossRefPubMed
8.
DiBlasio CJ, Hammett J, Malcolm JB, Judge BA, Womack JH, Kincade MC, Ogles ML, Mancini JG, Patterson AL, Wake RW, et al: Prevalence and predictive factors for the development of de novo psychiatric illness in patients receiving androgen deprivation therapy for prostate cancer. Can J Urol. 2008, 15 (5): 4249-4256.PubMed
9.
Beer TM, Bland LB, Bussiere JR, Neiss MB, Wersinger EM, Garzotto M, Ryan CW, Janowsky JS: Testosterone loss and estradiol administration modify memory in men. J Urol. 2006, 175 (1): 130-135. 10.1016/S0022-5347(05)00049-2.CrossRefPubMed
10.
Green HJ, Pakenham KI, Gardiner RA: Effects of lutenizing hormone releasing hormone analogs on cognition in women and men: A review. Psychology, Health and Medicine. 2000, 5 (4): 407-418. 10.1080/713690212.CrossRef
11.
Cherrier MM, Rose AL, Higano C: The effects of combined androgen blockade on cognitive function during the first cycle of intermittent androgen suppression in patients with prostate cancer. J Urol. 2003, 170 (5): 1808-1811. 10.1097/01.ju.0000091640.59812.83.CrossRefPubMed
12.
Salminen EK, Portin RI, Koskinen A, Helenius H, Nurmi M: Associations between serum testosterone fall and cognitive function in prostate cancer patients. Clin Cancer Res. 2004, 10 (22): 7575-7582. 10.1158/1078-0432.CCR-04-0750.CrossRefPubMed
13.
Epstein R, Kanwisher N: A cortical representation of the local visual environment. Nature. 1998, 392 (6676): 598-601. 10.1038/33402.CrossRefPubMed
14.
Hartley T, Maguire EA, Spiers HJ, Burgess N: The well-worn route and the path less traveled: distinct neural bases of route following and wayfinding in humans. Neuron. 2003, 37 (5): 877-888. 10.1016/S0896-6273(03)00095-3.CrossRefPubMed
15.
Hayes SM, Ryan L, Schnyer DM, Nadel L: An fMRI study of episodic memory: retrieval of object, spatial, and temporal information. Behav Neurosci. 2004, 118 (5): 885-896. 10.1037/0735-7044.118.5.885.CrossRefPubMedPubMedCentral
16.
Halari R, Sharma T, Hines M, Andrew C, Simmons A, Kumari V: Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and women. Experimental brain research Experimentelle Hirnforschung. 2006, 169 (1): 1-14. 10.1007/s00221-005-0118-7.CrossRefPubMed
17.
Hugdahl K, Thomsen T, Ersland L: Sex differences in visuo-spatial processing: an fMRI study of mental rotation. Neuropsychologia. 2006, 44 (9): 1575-1583. 10.1016/j.neuropsychologia.2006.01.026.CrossRefPubMed
18.
Schoning S, Engelien A, Kugel H, Schafer S, Schiffbauer H, Zwitserlood P, Pletziger E, Beizai P, Kersting A, Ohrmann P, et al: Functional anatomy of visuo-spatial working memory during mental rotation is influenced by sex, menstrual cycle, and sex steroid hormones. Neuropsychologia. 2007
19.
Sommer IE, Cohen-Kettenis PT, van Raalten T, Vd Veer AJ, Ramsey LE, Gooren LJ, Kahn RS, Ramsey NF: Effects of cross-sex hormones on cerebral activation during language and mental rotation: An fMRI study in transsexuals. Eur Neuropsychopharmacol. 2008, 18 (3): 215-221. 10.1016/j.euroneuro.2007.10.002.CrossRefPubMed
20.
Cherrier MM, Aubin S, Higano CS: Cognitive and Mood Changes in Men Undergoing Intermittent Combined Androgen Blockade for Non-Metastatic Prostate Cancer. Psycho-Oncology. 2008, 18 (3): 237-247. 10.1002/pon.1401.CrossRef
21.
Shelton AL, Gabrieli JD: Neural correlates of encoding space from route and survey perspectives. J Neurosci. 2002, 22 (7): 2711-2717.PubMed
22.
Shelton AL, McNamara TP: Spatial memory and perspective taking. Memory & cognition. 2004, 32 (3): 416-426.CrossRef
23.
Cohen JD, MacWhinney B, Flatt M, Provost J: Psyscope: A new graphic interface environment for designing psychological experiments. Behavioral Research Methods, Instruments and Computers. 1993, 25:
24.
Shepard RN, Metzler J: Mental rotation of three-dimensional objects. Science. 1971, 171 (972): 701-703. 10.1126/science.171.3972.701.CrossRefPubMed
25.
Shepard S, Metzler D: Mental rotation: effects of dimensionality of objects and type of task. J Exp Psychol Hum Percept Perform. 1988, 14 (1): 3-11. 10.1037/0096-1523.14.1.3.CrossRefPubMed
26.
Jenkinson M, Bannister P, Brady M, Smith S: Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 2002, 17 (2): 825-841. 10.1016/S1053-8119(02)91132-8.CrossRefPubMed
27.
Beckmann CF, Smith SM: Probabilistic Independent Component Analysis for Functional Magnetic Resonance Imaging. IEEE Trans Med Imaging. 2004, 23 (2): 137-152. 10.1109/TMI.2003.822821.CrossRefPubMed
28.
Jenkinson M, Smith S: A global optimisation method for robust affine registration of brain images. Medical image analysis. 2001, 5 (2): 143-156. 10.1016/S1361-8415(01)00036-6.CrossRefPubMed
29.
Woolrich MW, Behrens TE, Beckmann CF, Jenkinson M, Smith SM: Multilevel linear modelling for FMRI group analysis using Bayesian inference. Neuroimage. 2004, 21 (4): 1732-1747. 10.1016/j.neuroimage.2003.12.023.CrossRefPubMed
30.
Woolrich MW, Jenkinson M, Brady JM, Smith SM: Fully Bayesian spatio-temporal modeling of FMRI data. IEEE transactions on medical imaging. 2004, 23 (2): 213-231. 10.1109/TMI.2003.823065.CrossRefPubMed
31.
Jenkins VA, Bloomfield DJ, Shilling VM, Edginton TL: Does neoadjuvant hormone therapy for early prostate cancer affect cognition? Results from a pilot study. BJU Int. 2005, 96 (1): 48-53. 10.1111/j.1464-410X.2005.05565.x.CrossRefPubMed
32.
Almeida OP, Waterreus A, Spry N, Flicker L, Martins RN: One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men. Psychoneuroendocrinology. 2004, 29 (8): 1071-1081. 10.1016/j.psyneuen.2003.11.002.CrossRefPubMed
33.
Aso T, Hanakawa T, Matsuo K, Toma K, Shibasaki H, Fukuyama H, Nakai T: Subregions of human parietal cortex selectively encoding object orientation. Neurosci Lett. 2007, 415 (3): 225-230. 10.1016/j.neulet.2007.01.051.CrossRefPubMed
34.
Shelton AL, Pippitt HA: Motion in the mind's eye: comparing mental and visual rotation. Cogn Affect Behav Neurosci. 2006, 6 (4): 323-332. 10.3758/CABN.6.4.323.CrossRefPubMed
35.
Gizewski ER, Krause E, Wanke I, Forsting M, Senf W: Gender-specific cerebral activation during cognitive tasks using functional MRI: comparison of women in mid-luteal phase and men. Neuroradiology. 2006, 48 (1): 14-20. 10.1007/s00234-005-0004-9.CrossRefPubMed
36.
Jordan K, Wustenberg T, Heinze HJ, Peters M, Jancke L: Women and men exhibit different cortical activation patterns during mental rotation tasks. Neuropsychologia. 2002, 40 (13): 2397-2408. 10.1016/S0028-3932(02)00076-3.CrossRefPubMed
37.
Kimura D: Sex and Cognition. 1999, Cambridge, MA: The MIT Press
38.
Driscoll I, Hamilton DA, Yeo RA, Brooks WM, Sutherland RJ: Virtual navigation in humans: the impact of age, sex, and hormones on place learning. Horm Behav. 2005, 47 (3): 326-335. 10.1016/j.yhbeh.2004.11.013.CrossRefPubMed
39.
Hooven CK, Chabris CF, Ellison PT, Kosslyn SM: The relationship of male testosterone to components of mental rotation. Neuropsychologia. 2004, 42 (6): 782-790. 10.1016/j.neuropsychologia.2003.11.012.CrossRefPubMed
40.
Shelton AL, Pippitt HA: Fixed versus dynamic orientations in environmental learning from ground-level and aerial perspectives. Psychological research. 2007, 71 (3): 333-346. 10.1007/s00426-006-0088-9.CrossRefPubMed
41.
Zitzmann M, Weckesser M, Schober O, Nieschlag E: Changes in cerebral glucose metabolism and visuospatial capability in hypogonadal males under testosterone substitution therapy. Exp Clin Endocrinol Diabetes. 2001, 109 (5): 302-304. 10.1055/s-2001-16351.CrossRefPubMed
42.
Moffat SD, Resnick SM: Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Neurobiol Aging. 2007, 28: 914-920. 10.1016/j.neurobiolaging.2006.04.001.CrossRefPubMed
43.
Maki PM, Ernst M, London ED, Mordecai KL, Perschler P, Durso SC, Brandt J, Dobs A, Resnick SM: Intramuscular Testosterone Treatment in Elderly Men: Evidence of Memory Decline and Altered Brain Function. J Clin Endocrinol Metab. 2007
44.
Hinkin CH, van Gorp WG, Satz P, Marcotte T, Durvasula RS, Wood S, Campbell L, Baluda MR: Actual versus self-reported cognitive dysfunction in HIV-1 infection: memory-metamemory dissociations. J Clin Exp Neuropsychol. 1996, 18 (3): 431-443. 10.1080/01688639608408999.CrossRefPubMed
45.
Snitz BE, Morrow LA, Rodriguez EG, Huber KA, Saxton JA: Subjective memory complaints and concurrent memory performance in older patients of primary care providers. J Int Neuropsychol Soc. 2008, 14 (6): 1004-1013. 10.1017/S1355617708081332.CrossRefPubMedPubMedCentral
46.
Mitchell AJ: The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis. Int J Geriatr Psychiatry. 2008, 23 (11): 1191-1202. 10.1002/gps.2053.CrossRefPubMed
47.
Jacobs SR, Jacobsen PB, Booth-Jones M, Wagner LI, Anasetti C: Evaluation of the functional assessment of cancer therapy cognitive scale with hematopoietic stem cell transplant patients. J Pain Symptom Manage. 2007, 33 (1): 13-23. 10.1016/j.jpainsymman.2006.06.011.CrossRefPubMed
48.
McDonald BC, Saykin AJ, Ahles TA: Brain Imaging Investigation of Chemotherapy-Induced Neurocognitive Changes. Cancer and Cognition. Edited by: Meyers CA, Perry JR. 2008, New York: Cambridge, 19-32. full_text.CrossRef
Metadata
Title
Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study
Authors
Monique M Cherrier
Paul R Borghesani
Amy L Shelton
Celestia S Higano
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2010
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-10-1

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