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Published in: BMC Pregnancy and Childbirth 1/2007

Open Access 01-06-2007 | Proceedings

Protein kinase C and human uterine contractility

Authors: Isabelle Eude-Le Parco, Emmanuelle Dallot, Michelle Breuiller-Fouché

Published in: BMC Pregnancy and Childbirth | Special Issue 1/2007

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Abstract

Abnormalities in uterine contractility are thought to contribute to several clinical problems, including preterm labor. A better understanding of the mechanisms controlling uterine activity would make it possible to propose more appropriate and effective management practices than those currently in use. Recent advances point to a role of the protein kinase C (PRKC) family in the regulation of uterine smooth muscle contraction at the end of pregnancy. In this review, we highlight recent work that explores the involvement of individual PRKC isoforms in cellular process, with an emphasis on the properties of PRKCZ isoform.
Literature
1.
go back to reference Hertelendy F, Zakar T: Regulation of myometrial smooth muscle functions. Curr Pharm Des. 2004, 10 (20): 2499-2517. 10.2174/1381612043383926.CrossRefPubMed Hertelendy F, Zakar T: Regulation of myometrial smooth muscle functions. Curr Pharm Des. 2004, 10 (20): 2499-2517. 10.2174/1381612043383926.CrossRefPubMed
2.
go back to reference Carbonne B, Mignot TM, Tsatsaris V, Ferre F: Changes in plasma and amniotic fluid endothelin levels during pregnancy: facts or artefacts?. Eur J Obstet Gynecol Reprod Biol. 1998, 76 (1): 15-19. 10.1016/S0301-2115(97)00141-3.CrossRefPubMed Carbonne B, Mignot TM, Tsatsaris V, Ferre F: Changes in plasma and amniotic fluid endothelin levels during pregnancy: facts or artefacts?. Eur J Obstet Gynecol Reprod Biol. 1998, 76 (1): 15-19. 10.1016/S0301-2115(97)00141-3.CrossRefPubMed
3.
go back to reference Word RA, Kamm KE, Stull JT, Casey ML: Endothelin increases cytoplasmic calcium and myosin phosphorylation in human myometrium. Am J Obstet Gynecol. 1990, 162 (4): 1103-1108.CrossRefPubMed Word RA, Kamm KE, Stull JT, Casey ML: Endothelin increases cytoplasmic calcium and myosin phosphorylation in human myometrium. Am J Obstet Gynecol. 1990, 162 (4): 1103-1108.CrossRefPubMed
4.
go back to reference Osada K, Tsunoda H, Miyauchi T, Sugishita Y, Kubo T, Goto K: Pregnancy increases ET-1-induced contraction and changes receptor subtypes in uterine smooth muscle in humans. Am J Physiol. 1997, 272 (2 Pt 2): R541-548.PubMed Osada K, Tsunoda H, Miyauchi T, Sugishita Y, Kubo T, Goto K: Pregnancy increases ET-1-induced contraction and changes receptor subtypes in uterine smooth muscle in humans. Am J Physiol. 1997, 272 (2 Pt 2): R541-548.PubMed
5.
go back to reference Honore JC, Robert B, Vacher-Lavenu MC, Chapron C, Breuiller-Fouche M, Ferre F: Expression of endothelin receptors in human myometrium during pregnancy and in uterine leiomyomas. J Cardiovasc Pharmacol. 2000, 36 (5 Suppl 1): S386-389.CrossRefPubMed Honore JC, Robert B, Vacher-Lavenu MC, Chapron C, Breuiller-Fouche M, Ferre F: Expression of endothelin receptors in human myometrium during pregnancy and in uterine leiomyomas. J Cardiovasc Pharmacol. 2000, 36 (5 Suppl 1): S386-389.CrossRefPubMed
6.
go back to reference Kim B, Kim YS, Ahn J, Kim J, Cho S, Won KJ, Ozaki H, Karaki H, Lee SM: Conventional-type protein kinase C contributes to phorbol ester-induced inhibition of rat myometrial tension. Br J Pharmacol. 2003, 139 (2): 408-414. 10.1038/sj.bjp.0705237.PubMedCentralCrossRefPubMed Kim B, Kim YS, Ahn J, Kim J, Cho S, Won KJ, Ozaki H, Karaki H, Lee SM: Conventional-type protein kinase C contributes to phorbol ester-induced inhibition of rat myometrial tension. Br J Pharmacol. 2003, 139 (2): 408-414. 10.1038/sj.bjp.0705237.PubMedCentralCrossRefPubMed
7.
go back to reference Phillippe M: Protein kinase C, an inhibitor of oxytocin-stimulated phasic myometrial contractions. Biol Reprod. 1994, 50 (4): 855-859. 10.1095/biolreprod50.4.855.CrossRefPubMed Phillippe M: Protein kinase C, an inhibitor of oxytocin-stimulated phasic myometrial contractions. Biol Reprod. 1994, 50 (4): 855-859. 10.1095/biolreprod50.4.855.CrossRefPubMed
8.
go back to reference Savineau JP, Mironneau J: An analysis of the action of phorbol 12, 13-dibutyrate on mechanical activity in rat uterine smooth muscle. J Pharmacol Exp Ther. 1990, 255 (1): 133-139.PubMed Savineau JP, Mironneau J: An analysis of the action of phorbol 12, 13-dibutyrate on mechanical activity in rat uterine smooth muscle. J Pharmacol Exp Ther. 1990, 255 (1): 133-139.PubMed
9.
go back to reference Robin P, Boulven I, Desmyter C, Harbon S, Leiber D: ET-1 stimulates ERK signaling pathway through sequential activation of PRKC and Src in rat myometrial cells. Am J Physiol Cell Physiol. 2002, 283 (1): C251-260.CrossRefPubMed Robin P, Boulven I, Desmyter C, Harbon S, Leiber D: ET-1 stimulates ERK signaling pathway through sequential activation of PRKC and Src in rat myometrial cells. Am J Physiol Cell Physiol. 2002, 283 (1): C251-260.CrossRefPubMed
10.
go back to reference Taggart MJ, Leavis P, Feron O, Morgan KG: Inhibition of PKCalpha and rhoA translocation in differentiated smooth muscle by a caveolin scaffolding domain peptide. Exp Cell Res. 2000, 258 (1): 72-81. 10.1006/excr.2000.4891.CrossRefPubMed Taggart MJ, Leavis P, Feron O, Morgan KG: Inhibition of PKCalpha and rhoA translocation in differentiated smooth muscle by a caveolin scaffolding domain peptide. Exp Cell Res. 2000, 258 (1): 72-81. 10.1006/excr.2000.4891.CrossRefPubMed
11.
go back to reference Liu WS, Heckman CA: The sevenfold way of PKC regulation. Cell Signal. 1998, 10 (8): 529-542. 10.1016/S0898-6568(98)00012-6.CrossRefPubMed Liu WS, Heckman CA: The sevenfold way of PKC regulation. Cell Signal. 1998, 10 (8): 529-542. 10.1016/S0898-6568(98)00012-6.CrossRefPubMed
12.
go back to reference Parker PJ, Murray-Rust J: PKC at a glance. J Cell Sci. 2004, 117 (Pt 2): 131-132. 10.1242/jcs.00982.CrossRefPubMed Parker PJ, Murray-Rust J: PKC at a glance. J Cell Sci. 2004, 117 (Pt 2): 131-132. 10.1242/jcs.00982.CrossRefPubMed
13.
go back to reference Eude I, Paris B, Cabrol D, Ferre F, Breuiller-Fouche M: Selective protein kinase C isoforms are involved in endothelin-1-induced human uterine contraction at the end of pregnancy. Biol Reprod. 2000, 63 (5): 1567-1573. 10.1095/biolreprod63.5.1567.CrossRefPubMed Eude I, Paris B, Cabrol D, Ferre F, Breuiller-Fouche M: Selective protein kinase C isoforms are involved in endothelin-1-induced human uterine contraction at the end of pregnancy. Biol Reprod. 2000, 63 (5): 1567-1573. 10.1095/biolreprod63.5.1567.CrossRefPubMed
14.
go back to reference Hurd WW, Fomin VP, Natarajan V, Brown HL, Bigsby RM, Singh DM: Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium. Am J Obstet Gynecol. 2000, 183 (6): 1525-1531. 10.1067/mob.2000.107783.CrossRefPubMed Hurd WW, Fomin VP, Natarajan V, Brown HL, Bigsby RM, Singh DM: Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium. Am J Obstet Gynecol. 2000, 183 (6): 1525-1531. 10.1067/mob.2000.107783.CrossRefPubMed
15.
go back to reference Di Liberto G, Dallot E, Eude-Le Parco I, Cabrol D, Ferre F, Breuiller-Fouche M: A critical role for PKC zeta in endothelin-1-induced uterine contractions at the end of pregnancy. Am J Physiol Cell Physiol. 2003, 285 (3): C599-607.CrossRefPubMed Di Liberto G, Dallot E, Eude-Le Parco I, Cabrol D, Ferre F, Breuiller-Fouche M: A critical role for PKC zeta in endothelin-1-induced uterine contractions at the end of pregnancy. Am J Physiol Cell Physiol. 2003, 285 (3): C599-607.CrossRefPubMed
16.
go back to reference Dallot E, Pouchelet M, Gouhier N, Cabrol D, Ferre F, Breuiller-Fouche M: Contraction of cultured human uterine smooth muscle cells after stimulation with endothelin-1. Biol Reprod. 2003, 68 (3): 937-942. 10.1095/biolreprod.102.008367.CrossRefPubMed Dallot E, Pouchelet M, Gouhier N, Cabrol D, Ferre F, Breuiller-Fouche M: Contraction of cultured human uterine smooth muscle cells after stimulation with endothelin-1. Biol Reprod. 2003, 68 (3): 937-942. 10.1095/biolreprod.102.008367.CrossRefPubMed
17.
go back to reference Ozaki H, Yasuda K, Kim YS, Egawa M, Kanzaki H, Nakazawa H, Hori M, Seto M, Karaki H: Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation. Br J Pharmacol. 2003, 140 (7): 1303-1312. 10.1038/sj.bjp.0705552.PubMedCentralCrossRefPubMed Ozaki H, Yasuda K, Kim YS, Egawa M, Kanzaki H, Nakazawa H, Hori M, Seto M, Karaki H: Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation. Br J Pharmacol. 2003, 140 (7): 1303-1312. 10.1038/sj.bjp.0705552.PubMedCentralCrossRefPubMed
18.
go back to reference Bermeo ME, Fomin VP, Ventolini G, Gibbs SG, McKenna DS, Hurd WW: Magnesium sulfate induces translocation of protein kinase C isoenzymes alpha and delta in myometrial cells from pregnant women. Am J Obstet Gynecol. 2004, 190 (2): 522-527. 10.1016/j.ajog.2003.09.009.CrossRefPubMed Bermeo ME, Fomin VP, Ventolini G, Gibbs SG, McKenna DS, Hurd WW: Magnesium sulfate induces translocation of protein kinase C isoenzymes alpha and delta in myometrial cells from pregnant women. Am J Obstet Gynecol. 2004, 190 (2): 522-527. 10.1016/j.ajog.2003.09.009.CrossRefPubMed
19.
go back to reference Arntzen KJ, Kjollesdal AM, Halgunset J, Vatten L, Austgulen R: TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. J Perinat Med. 1998, 26 (1): 17-26.CrossRefPubMed Arntzen KJ, Kjollesdal AM, Halgunset J, Vatten L, Austgulen R: TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. J Perinat Med. 1998, 26 (1): 17-26.CrossRefPubMed
20.
go back to reference Leitges M, Sanz L, Martin P, Duran A, Braun U, Garcia JF, Camacho F, Diaz-Meco MT, Rennert PD, Moscat J: Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell. 2001, 8 (4): 771-780. 10.1016/S1097-2765(01)00361-6.CrossRefPubMed Leitges M, Sanz L, Martin P, Duran A, Braun U, Garcia JF, Camacho F, Diaz-Meco MT, Rennert PD, Moscat J: Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell. 2001, 8 (4): 771-780. 10.1016/S1097-2765(01)00361-6.CrossRefPubMed
21.
go back to reference Ghosh S, Karin M: Missing pieces in the NF-kappaB puzzle. Cell. 2002, 109 (Suppl): S81-96. 10.1016/S0092-8674(02)00703-1.CrossRefPubMed Ghosh S, Karin M: Missing pieces in the NF-kappaB puzzle. Cell. 2002, 109 (Suppl): S81-96. 10.1016/S0092-8674(02)00703-1.CrossRefPubMed
22.
go back to reference Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J: zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. Embo J. 1994, 13 (12): 2842-2848.PubMedCentralPubMed Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J: zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. Embo J. 1994, 13 (12): 2842-2848.PubMedCentralPubMed
23.
go back to reference Goldenberg RL, Hauth JC, Andrews WW: Intrauterine infection and preterm delivery. N Engl J Med. 2000, 342 (20): 1500-1507. 10.1056/NEJM200005183422007.CrossRefPubMed Goldenberg RL, Hauth JC, Andrews WW: Intrauterine infection and preterm delivery. N Engl J Med. 2000, 342 (20): 1500-1507. 10.1056/NEJM200005183422007.CrossRefPubMed
24.
go back to reference Mackler AM, Ducsay TC, Ducsay CA, Yellon SM: Effects of endotoxin and macrophage-related cytokines on the contractile activity of the gravid murine uterus. Biol Reprod. 2003, 69 (4): 1165-1169. 10.1095/biolreprod.103.015586.CrossRefPubMed Mackler AM, Ducsay TC, Ducsay CA, Yellon SM: Effects of endotoxin and macrophage-related cytokines on the contractile activity of the gravid murine uterus. Biol Reprod. 2003, 69 (4): 1165-1169. 10.1095/biolreprod.103.015586.CrossRefPubMed
25.
go back to reference Elovitz MA, Wang Z, Chien EK, Rychlik DF, Phillippe M: A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol. 2003, 163 (5): 2103-2111.PubMedCentralCrossRefPubMed Elovitz MA, Wang Z, Chien EK, Rychlik DF, Phillippe M: A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol. 2003, 163 (5): 2103-2111.PubMedCentralCrossRefPubMed
26.
go back to reference Fidel PL, Romero R, Ramirez M, Cutright J, Edwin SS, LaMarche S, Cotton DB, Mitchell MD: Interleukin-1 receptor antagonist (IL-1ra) production by human amnion, chorion, and decidua. Am J Reprod Immunol. 1994, 32 (1): 1-7.CrossRefPubMed Fidel PL, Romero R, Ramirez M, Cutright J, Edwin SS, LaMarche S, Cotton DB, Mitchell MD: Interleukin-1 receptor antagonist (IL-1ra) production by human amnion, chorion, and decidua. Am J Reprod Immunol. 1994, 32 (1): 1-7.CrossRefPubMed
27.
go back to reference Schmitz T, Souil E, Hervé R, Nicco C, Batteux F, Germain G, Cabrol D, Evain-Brion D, Leroy MJ, Mehats C: PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation. J Immunol. 2007, 178: 1115-1121.CrossRefPubMed Schmitz T, Souil E, Hervé R, Nicco C, Batteux F, Germain G, Cabrol D, Evain-Brion D, Leroy MJ, Mehats C: PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation. J Immunol. 2007, 178: 1115-1121.CrossRefPubMed
28.
go back to reference Romero R, Chaiworapongsa T, Kuivaniemi H, Tromp G: Bacterial vaginosis, the inflammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth. Am J Obstet Gynecol. 2004, 190 (6): 1509-1519. 10.1016/j.ajog.2004.01.002.CrossRefPubMed Romero R, Chaiworapongsa T, Kuivaniemi H, Tromp G: Bacterial vaginosis, the inflammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth. Am J Obstet Gynecol. 2004, 190 (6): 1509-1519. 10.1016/j.ajog.2004.01.002.CrossRefPubMed
29.
go back to reference Guha M, Mackman N: LPS induction of gene expression in human monocytes. Cell Signal. 2001, 13 (2): 85-94. 10.1016/S0898-6568(00)00149-2.CrossRefPubMed Guha M, Mackman N: LPS induction of gene expression in human monocytes. Cell Signal. 2001, 13 (2): 85-94. 10.1016/S0898-6568(00)00149-2.CrossRefPubMed
30.
go back to reference Dallot E, Mehats C, Oger S, Leroy MJ, Breuiller-Fouche M: A role for PKCzeta in the LPS-induced translocation NF-kappaB p65 subunit in cultured myometrial cells. Biochimie. 2005, 87 (6): 513-521. 10.1016/j.biochi.2005.02.009.CrossRefPubMed Dallot E, Mehats C, Oger S, Leroy MJ, Breuiller-Fouche M: A role for PKCzeta in the LPS-induced translocation NF-kappaB p65 subunit in cultured myometrial cells. Biochimie. 2005, 87 (6): 513-521. 10.1016/j.biochi.2005.02.009.CrossRefPubMed
31.
go back to reference Chapman NR, Europe-Finner GN, Robson SC: Expression and Deoxyribonucleic Acid-Binding Activity of the Nuclear Factor {kappa}B Family in the Human Myometrium during Pregnancy and Labor. J Clin Endocrinol Metab. 2004, 89 (11): 5683-5693. 10.1210/jc.2004-0873.CrossRefPubMed Chapman NR, Europe-Finner GN, Robson SC: Expression and Deoxyribonucleic Acid-Binding Activity of the Nuclear Factor {kappa}B Family in the Human Myometrium during Pregnancy and Labor. J Clin Endocrinol Metab. 2004, 89 (11): 5683-5693. 10.1210/jc.2004-0873.CrossRefPubMed
32.
go back to reference Allport VC, Pieber D, Slater DM, Newton R, White JO, Bennett PR: Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'. Mol Hum Reprod. 2001, 7 (6): 581-586. 10.1093/molehr/7.6.581.CrossRefPubMed Allport VC, Pieber D, Slater DM, Newton R, White JO, Bennett PR: Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'. Mol Hum Reprod. 2001, 7 (6): 581-586. 10.1093/molehr/7.6.581.CrossRefPubMed
33.
go back to reference Duggan SV, Lindstrom T, Iglesias T, Bennett PR, Mann GE, Bartlett SR: Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells. J Cell Physiol. 2007, 210: 637-643. 10.1002/jcp.20901.CrossRefPubMed Duggan SV, Lindstrom T, Iglesias T, Bennett PR, Mann GE, Bartlett SR: Role of atypical protein kinase C isozymes and NF-kappaB in IL-1beta-induced expression of cyclooxygenase-2 in human myometrial smooth muscle cells. J Cell Physiol. 2007, 210: 637-643. 10.1002/jcp.20901.CrossRefPubMed
Metadata
Title
Protein kinase C and human uterine contractility
Authors
Isabelle Eude-Le Parco
Emmanuelle Dallot
Michelle Breuiller-Fouché
Publication date
01-06-2007
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue Special Issue 1/2007
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/1471-2393-7-S1-S11

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