Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Neurology
Published in: BMC Neurology 1/2007

Open Access 01-12-2007 | Research article

Perception versus polysomnographic assessment of sleep in CFS and non-fatigued control subjects: results from a population-based study

Authors: Matthias Majer, James F Jones, Elizabeth R Unger, Laura Solomon Youngblood, Michael J Decker, Brian Gurbaxani, Christine Heim, William C Reeves

Published in: BMC Neurology | Issue 1/2007

Login to get access

Abstract

Background

Complaints of unrefreshing sleep are a prominent component of chronic fatigue syndrome (CFS); yet, polysomnographic studies have not consistently documented sleep abnormalities in CFS patients. We conducted this study to determine whether alterations in objective sleep characteristics are associated with subjective measures of poor sleep quality in persons with CFS.

Methods

We examined the relationship between perceived sleep quality and polysomnographic measures of nighttime and daytime sleep in 35 people with CFS and 40 non-fatigued control subjects, identified from the general population of Wichita, Kansas and defined by empiric criteria. Perceived sleep quality and daytime sleepiness were assessed using clinical sleep questionnaires. Objective sleep characteristics were assessed by nocturnal polysomnography and daytime multiple sleep latency testing.

Results

Participants with CFS reported unrefreshing sleep and problems sleeping during the preceding month significantly more often than did non-fatigued controls. Participants with CFS also rated their quality of sleep during the overnight sleep study as significantly worse than did control subjects. Control subjects reported significantly longer sleep onset latency than latency to fall asleep as measured by PSG and MSLT. There were no significant differences in sleep pathology or architecture between subjects with CFS and control subjects.

Conclusion

People with CFS reported sleep problems significantly more often than control subjects. Yet, when measured these parameters and sleep architecture did not differ between the two subject groups. A unique finding requiring further study is that control, but not CFS subjects, significantly over reported sleep latency suggesting CFS subjects may have an increased appreciation of sleep behaviour that may contribute to their perception of sleep problems.
Literature
1.
Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A: The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994, 121: 953-959.CrossRefPubMed
2.
Buchwald D, Pascualy R, Bombardier C, Kith P: Sleep disorders in patients with chronic fatigue. Clin Infect Dis. 1994, 18 Suppl 1: S68-S72.CrossRefPubMed
3.
Krupp LB, Jandorf L, Coyle PK, Mendelson WB: Sleep disturbance in chronic fatigue syndrome. J Psychosom Res. 1993, 37: 325-331. 10.1016/0022-3999(93)90134-2.CrossRefPubMed
4.
Schaefer KM: Sleep disturbances and fatigue in women with fibromyalgia and chronic fatigue syndrome. J Obstet Gynecol Neonatal Nurs. 1995, 24: 229-233. 10.1111/j.1552-6909.1995.tb02467.x.CrossRefPubMed
5.
Sharpley A, Clements A, Hawton K, Sharpe M: Do patients with pure chronic fatigue syndrome (neurasthenia) have abnormal sleep?. Psychosom Med. 1997, 59: 592-596.CrossRefPubMed
6.
Unger ER, Nisenbaum R, Moldofsky H, Cesta A, Sammut C, Reyes M, Reeves WC: Sleep assessment in a population-based study of chronic fatigue syndrome. BMC Neurol. 2004, 4: 6-10.1186/1471-2377-4-6.CrossRefPubMedPubMedCentral
7.
Gurbaxani BM, Goertzel BN, Jones JF, Maloney EB: Linear Data Mining the Wichita Clinical Matrix Suggests Sleep and Allostatic Load Involvement in Chronic Fatigue Syndrome. Pharmacogenomics. 2006, 7: 455-465. 10.2217/14622416.7.3.455.CrossRefPubMed
8.
Nisenbaum R, Jones JF, Unger ER, Reyes M, Reeves WC: A population-based study of the clinical course of chronic fatigue syndrome. Health. Qual Life Outcomes. 2003, 1: 49-10.1186/1477-7525-1-49.CrossRef
9.
NIH State-of-the-Science Conference Statement on manifestations and management of chronic insomnia in adults. NIH Consens State Sci Statements. 2005, 22 (2): 1-30.
10.
Reeves WC, Lloyd A, Vernon SD, Klimas N, Jason LA, Bleijenberg G, Evengard B, White PD, Nisenbaum R, Unger ER, International Chronic Fatigue Syndrome Study Group: Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res. 2003, 3: 25-10.1186/1472-6963-3-25.CrossRefPubMedPubMedCentral
11.
Fischler B: Review of clinical and psychobiological dimensions of the chronic fatigue syndrome: differentiation from depression and contribution of sleep dysfunctions. Sleep Medicine Reviews. 1999, 3: 131-146. 10.1016/S1087-0792(99)90020-5.CrossRefPubMed
12.
Reeves WC, Heim C, Maloney EM, Youngblood LS, Unger ER, Decker MJ, Jones JF, Rye DB: Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study. BMC Neurol. 2006, 6: 41-10.1186/1471-2377-6-41.CrossRefPubMedPubMedCentral
13.
Vollmer-Conna U, Aslakson E, White PD: An empirical delineation of the heterogeneity of chronic unexplained fatigue in women. Pharmacogenomics. 2006, 7: 355-364. 10.2217/14622416.7.3.355.CrossRefPubMed
14.
Fossey M, Libman E, Bailes S, Baltzan M, Schondorf R, Amsel R, Fichten CS: Sleep quality and psychological adjustment in chronic fatigue syndrome. J Behav Med. 2004, 27: 581-605. 10.1007/s10865-004-0004-y.CrossRefPubMed
15.
Watson NF, Jacobsen C, Goldberg J, Kapur V, Buchwald D: Subjective and objective sleepiness in monozygotic twins discordant for chronic fatigue syndrome. Sleep. 2004, 27: 973-977.PubMed
16.
Watson NF, Kapur V, Arguelles LM, Goldberg J, Schmidt DF, Armitage R, Buchwald D: Comparison of subjective and objective measures of insomnia in monozygotic twins discordant for chronic fatigue syndrome. Sleep. 2003, 26: 324-328.PubMed
17.
American Academy of Sleep Medicine: International classification of sleep disorders, revised: Diagnostic and coding manual. 1990, Chicago, Illinois: American Academy of Sleep Medicine
18.
American Academy of Sleep Medicine: International classification of sleep disorders, 2nd edition: Diagnostic and coding manual. 2005, Westchester, Illinois: American Academy of Sleep Medicine
19.
Reeves WC, Wagner D, Nisenbaum R, Jones JF, Gurbaxani BM, Solomon L, Papanicolaou DA, Unger ER, Vernon SD, Heim C: Chronic fatigue syndrome – a clinically empirical approach to its definition and study. BMC Med. 2005, 3: 19-10.1186/1741-7015-3-19.CrossRefPubMedPubMedCentral
20.
Reyes M, Nisenbaum R, Hoaglin DC, Unger ER, Emmons C, Randall B, Stewart JA, Abbey S, Jones JF, Gantz N, Minden S, Reeves WC: Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas. Arch Intern Med. 2003, 163: 1530-1536. 10.1001/archinte.163.13.1530.CrossRefPubMed
21.
Smets EM, Garssen B, Bonke B, De Haes JC: The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995, 39: 315-325. 10.1016/0022-3999(94)00125-O.CrossRefPubMed
22.
Ware JE, Shebourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097/00005650-199206000-00002.CrossRefPubMed
23.
Wagner D, Nisenbaum R, Heim C, Jones JF, Unger ER, Reeves WC: Psychometric properties of the CDC symptom inventory for assessment of chronic fatigue syndrome. BMC Popul Health Metr. 2005, 3: 8-10.1186/1478-7954-3-8.CrossRef
24.
Carskadon M: Guidelines for the multiple sleep latency test (MSLT) A standard measure of sleepiness. Sleep. 1986, 9: 519-524.PubMed
25.
Carskadon M, Dement W: The multiple sleep latency test: what does it measure?. Sleep. 1982, 5: S67-72.PubMed
26.
Arand D, Bonnet M, Hurwitz T, Mitler M, Rosa R, Sangal R: The clinical use of the MSLT and MWT. Sleep. 2005, 28: 123-144.PubMed
27.
Thorpy MJ: The Clinical Use of the Multiple Sleep Latency Test. The Standards of Practice Committee of the American Sleep Disorders Association. Sleep. 1992, 15: 268-276.PubMed
28.
Benbadis SR, Perry M, Wolgamuth BR, Turnbull J, Mendelson WB: Mean versus median for the multiple sleep latency test. Sleep. 1995, 18: 342-345.PubMed
29.
Bonet M, Arand D: Activity, arousal and the MSLT in patients with insomnia. Sleep. 2000, 23: 205-212.
30.
American Sleep Disorders Association Atlas Task Force: Recording and scoring leg movements. Sleep. 1993, 16: 748-759.
31.
American Sleep Disorders Association Atlas Task Force: EEG arousals: scoring rules and examples. Sleep. 1992, 15: 173-184.
32.
Johns MW: A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991, 14: 540-545.PubMed
33.
Cesta A, Modofsky H, Sammut C: The University of Toronto Sleep Assessment Questionnaire (SAQ©). Sleep Res. 1996, 25: 486-
34.
Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc B. 1995, 57: 289-300.
35.
Morgan BJ: 1995 Principal component analysis and exploratory factor analysis. Stat Methods Med Res. 1992, 1: 69-95. 10.1177/096228029200100105.CrossRefPubMed
36.
American Psychiatric Association: Diagnostic and Statistical manual of Mental Disorders, Fourth Edition, Text Revision. 2000, Washington DC, American Psychiatric AssociationCrossRef
Metadata
Title
Perception versus polysomnographic assessment of sleep in CFS and non-fatigued control subjects: results from a population-based study
Authors
Matthias Majer
James F Jones
Elizabeth R Unger
Laura Solomon Youngblood
Michael J Decker
Brian Gurbaxani
Christine Heim
William C Reeves
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2007
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-7-40

Other articles of this Issue 1/2007

BMC Neurology 1/2007 Go to the issue

Study protocol

Protocol of a prospective study on the diagnostic value of transcranial duplex scanning of the substantia nigra in patients with parkinsonian symptoms

Case report

Pyramidal and extrapyramidal dysfunction as a sequela of hypoxic injury: case report

Research article

Thalamic haemorrhage vs internal capsule-basal ganglia haemorrhage: clinical profile and predictors of in-hospital mortality

Research article

Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study

Research article

A case-control study of occupational magnetic field exposure and Alzheimer's disease: results from the California Alzheimer's Disease Diagnosis and Treatment Centers

Research article

Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlates