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Open Access 01-12-2006 | Research article

Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD

Authors: Natividad Cuadrado-Corrales, Adolfo Jiménez-Huete, Carmen Albo, Rafael Hortigüela, Luz Vega, Laura Cerrato, Maríajosé Sierra-Moros, Alberto Rábano, Jesús de Pedro-Cuesta, Miguel Calero

Published in: BMC Neurology | Issue 1/2006

Abstract

Background

The 14-3-3 test appears to be a valuable aid for the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) in selected populations. However, its usefulness in routine practice has been challenged. In this study, the influence of the clinical context on the performance of the 14-3-3 test for the diagnosis of sCJD is investigated through the analysis of a large prospective clinical series.

Methods

Six hundred seventy-two Spanish patients with clinically suspected sCJD were analyzed. Clinical classification at sample reception according to the World Health Organization's (WHO) criteria (excluding the 14-3-3 test result) was used to explore the influence of the clinical context on the pre-test probabilities, and positive (PPV) and negative (NPV) predictive values of the 14-3-3 test.

Results

Predictive values of the test varied greatly according to the initial clinical classification: PPV of 98.8%, 96.5% and 45.0%, and NPV of 26.1%, 66.6% and 100% for probable sCJDi (n = 115), possible sCJDi (n = 73) and non-sCJDi (n = 484) cases, respectively. According to multivariate and Bayesian analyses, these values represent an improvement of diagnostic certainty compared to clinical data alone.

Conclusion

In three different contexts of sCJD suspicion, the 14-3-3 assay provides useful information complementary to clinical and electroencephalographic (EEG) data. The test is most useful supporting a clinical impression, whilst it may show deceptive when it is not in agreement with clinical data.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/6/25/prepub

Title: Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD
Authors: Natividad Cuadrado-Corrales
Adolfo Jiménez-Huete
Carmen Albo
Rafael Hortigüela
Luz Vega
Laura Cerrato
Maríajosé Sierra-Moros
Alberto Rábano
Jesús de Pedro-Cuesta
Miguel Calero
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2006
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/1471-2377-6-25

2024 ASCO Annual Meeting

Springer Medicine

Impact of the clinical context on the 14-3-3 test for the diagnosis of sporadic CJD

Abstract

Background

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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