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BMC Neurology

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Open Access 01-12-2006 | Research article

Population-based neuropathological studies of dementia: design, methods and areas of investigation – a systematic review

Authors: Julia Zaccai, Paul Ince, Carol Brayne

Published in: BMC Neurology | Issue 1/2006

Abstract

Background

Prospective population-based neuropathological studies have a special place in dementia research which is under emphasised.

Methods

A systematic review of the methods of population-based neuropathological studies of dementia was carried out. These studies were assessed in relation to their representativeness of underlying populations and the clinical, neuropsychological and neuropathological approaches adopted.

Results

Six studies were found to be true population-based neuropathological studies of dementia in the older people: the Hisayama study (Japan); Vantaa 85+ study (Finland); CC75C study (Cambridge, UK); CFAS (multicentre, UK); Cache County study (Utah, USA); HAAS (Hawaï, USA). These differ in the core characteristics of their populations. The studies used standardised neuropathological methods which facilitate analyses on: clinicopathological associations and confirmation of diagnosis, assessing the validity of hierarchical models of neuropathological lesion burden; investigating the associations between neuropathological burden and risk factors including genetic factors. Examples of findings are given although there is too little overlap in the areas investigated amongst these studies to form the basis of a systematic review of the results.

Conclusion

Clinicopathological studies based on true population samples can provide unique insights in dementia. Individually they are limited in power and scope; together they represent a powerful source to translate findings from laboratory to populations.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/6/2/prepub

Title: Population-based neuropathological studies of dementia: design, methods and areas of investigation – a systematic review
Authors: Julia Zaccai
Paul Ince
Carol Brayne
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2006
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/1471-2377-6-2

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Population-based neuropathological studies of dementia: design, methods and areas of investigation – a systematic review

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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