Skip to main content
Top
Published in: BMC Neurology 1/2014

Open Access 01-12-2014 | Case report

Cerebral hypoxia, missing cortical somatosensory evoked potentials and recovery of consciousness

Authors: Gustav Pfeiffer, Rüdiger Pfeifer, Stefan Isenmann

Published in: BMC Neurology | Issue 1/2014

Login to get access

Abstract

Background

Bilaterally absent N20 components of the sensory evoked potentials (SEP) from the median nerve are regarded as accurately predicting poor outcome after cardiac arrest.

Case presentation

We are reporting on a patient, who regained consciousness despite this ominous finding. Early after cardiac arrest, MRI showed signal alterations in diffusion weighted imaging (DWI) bilaterally in the primary visual and sensorimotor cortex and in the basal ganglia. SEP were repeatedly absent. The patient survived shut out form sensory and visual experience and locked in for voluntary movements, but kept her verbal competence in several languages.

Conclusion

SEP inform about integrity only of a narrow cortical strip. It is unguarded, but common practice, to conclude from absent SEP, that a patient has suffered diffuse cortical damage after cardiac arrest. Cerebral MRI with DWI helps to avoid this prognostic error and furthers understanding of the sometimes very peculiar state of mind after cardiac arrest.
Appendix
Available only for authorised users
Literature
1.
go back to reference Geocadin RG, Buitrago MM, Torbey MT, Chandra-Strobos N, Williams MA, Kaplan PW: Neurologic prognosis and withdrawal of life support after resuscitation from cardiac arrest. Neurology. 2006, 67: 105-108. 10.1212/01.wnl.0000223335.86166.b4.CrossRefPubMed Geocadin RG, Buitrago MM, Torbey MT, Chandra-Strobos N, Williams MA, Kaplan PW: Neurologic prognosis and withdrawal of life support after resuscitation from cardiac arrest. Neurology. 2006, 67: 105-108. 10.1212/01.wnl.0000223335.86166.b4.CrossRefPubMed
2.
go back to reference Zandbergen EG, Koelman JH, de Haan RJ, Hijdra J: For the PROPAC-study group. Neurology. 2006, 67: 583-586. 10.1212/01.wnl.0000230162.35249.7f.CrossRefPubMed Zandbergen EG, Koelman JH, de Haan RJ, Hijdra J: For the PROPAC-study group. Neurology. 2006, 67: 583-586. 10.1212/01.wnl.0000230162.35249.7f.CrossRefPubMed
3.
go back to reference Wijdicks EFM, Hijdra A, Young GB, Bassetti CL, Wiebe S: Practice Parameter: Prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review). Neurology. 2006, 67: 203-210. 10.1212/01.wnl.0000227183.21314.cd.CrossRefPubMed Wijdicks EFM, Hijdra A, Young GB, Bassetti CL, Wiebe S: Practice Parameter: Prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review). Neurology. 2006, 67: 203-210. 10.1212/01.wnl.0000227183.21314.cd.CrossRefPubMed
4.
go back to reference Stepan C, Haidinger G, Binder H: Die Problematik der klinischen Verlaufsbeurteilung von Patienten mit Apallischem Syndrom (AS) anhand von Rehabilitationsskalen – ein Überblick. J Neurol Neurochir Psychiatr. 2004, 5 (3): 14-22. http://www.kup.at/kup/pdf/4581.pdf, Stepan C, Haidinger G, Binder H: Die Problematik der klinischen Verlaufsbeurteilung von Patienten mit Apallischem Syndrom (AS) anhand von Rehabilitationsskalen – ein Überblick. J Neurol Neurochir Psychiatr. 2004, 5 (3): 14-22. http://​www.​kup.​at/​kup/​pdf/​4581.​pdf,
5.
go back to reference Betge S, Schulze-Bahr E, Fitzek C, Pfeifer R, Figulla HR, Witte OW, Isenmann S: Long QT syndrome causing grand mal epilepsy: case report, pedigree, therapeutic options, and review of the literature. Nervenarzt. 2006, 77: 1210-1217. 10.1007/s00115-006-2118-7.CrossRefPubMed Betge S, Schulze-Bahr E, Fitzek C, Pfeifer R, Figulla HR, Witte OW, Isenmann S: Long QT syndrome causing grand mal epilepsy: case report, pedigree, therapeutic options, and review of the literature. Nervenarzt. 2006, 77: 1210-1217. 10.1007/s00115-006-2118-7.CrossRefPubMed
7.
go back to reference Monti MM, Vanhaudenhuyse A, Coleman MR, Boly M, Pickard JD, Tshibanda L, Owen AM, Laureys S: Willful modulation of brain activity in disorders of consciousness. N Engl J Med. 2010, 362: 579-89. 10.1056/NEJMoa0905370.CrossRefPubMed Monti MM, Vanhaudenhuyse A, Coleman MR, Boly M, Pickard JD, Tshibanda L, Owen AM, Laureys S: Willful modulation of brain activity in disorders of consciousness. N Engl J Med. 2010, 362: 579-89. 10.1056/NEJMoa0905370.CrossRefPubMed
8.
go back to reference Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD: Detecting awareness in the vegetative state. Science. 2006, 313: 1402-10.1126/science.1130197.CrossRefPubMed Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD: Detecting awareness in the vegetative state. Science. 2006, 313: 1402-10.1126/science.1130197.CrossRefPubMed
9.
go back to reference Shiel A, Horn SA, Wilson BA, Watson MJ, Campbell MJ, McLellan DL: The Wessex Head Injury Matrix (WHIM) main scale: a preliminary report on a scale to assess and monitor patient recovery after severe head injury. Clin Rehabil. 2000, 14: 408-416. 10.1191/0269215500cr326oa.CrossRefPubMed Shiel A, Horn SA, Wilson BA, Watson MJ, Campbell MJ, McLellan DL: The Wessex Head Injury Matrix (WHIM) main scale: a preliminary report on a scale to assess and monitor patient recovery after severe head injury. Clin Rehabil. 2000, 14: 408-416. 10.1191/0269215500cr326oa.CrossRefPubMed
11.
go back to reference The Multi-Society Task Force on PVS: Medical aspects of the persistent vegetative state. N Engl J Med. 1994, 330: 1499-1508. 1572–9CrossRef The Multi-Society Task Force on PVS: Medical aspects of the persistent vegetative state. N Engl J Med. 1994, 330: 1499-1508. 1572–9CrossRef
12.
go back to reference Rossetti AO, Oddo M, Logroscino G, Kaplan PW: Prognostication after cardiac arrest and hypothermia. A prospective study. Ann Neurol. 2010, 67: 301-307.PubMed Rossetti AO, Oddo M, Logroscino G, Kaplan PW: Prognostication after cardiac arrest and hypothermia. A prospective study. Ann Neurol. 2010, 67: 301-307.PubMed
13.
go back to reference Bender A, Howell K, Frey M, Berlis A, Naumann M, Buheitel G: Bilateral loss of cortical SSEP responses is compatible with good Outcome after cardiac arrest. J Neurol. 2012, 259: 2481-2483. 10.1007/s00415-012-6573-8.CrossRefPubMed Bender A, Howell K, Frey M, Berlis A, Naumann M, Buheitel G: Bilateral loss of cortical SSEP responses is compatible with good Outcome after cardiac arrest. J Neurol. 2012, 259: 2481-2483. 10.1007/s00415-012-6573-8.CrossRefPubMed
14.
go back to reference Howell K, Grill E, Klein AM, Straube A, Bender A: Rehabilitation outcome of anoxic-ischemic encephalopathy survivors with prolonged disorders of consciousness. Resuscitation. 2013, 84: 1409-1415. 10.1016/j.resuscitation.2013.05.015.CrossRefPubMed Howell K, Grill E, Klein AM, Straube A, Bender A: Rehabilitation outcome of anoxic-ischemic encephalopathy survivors with prolonged disorders of consciousness. Resuscitation. 2013, 84: 1409-1415. 10.1016/j.resuscitation.2013.05.015.CrossRefPubMed
15.
go back to reference Zandbergen EG, Hijdra A, Koelman JH, Hart AA, Vos PE, Veerbek MM, de Haan RJ: PROPAC Study Group. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology. 2006, 66: 62-68. 10.1212/01.wnl.0000191308.22233.88.CrossRefPubMed Zandbergen EG, Hijdra A, Koelman JH, Hart AA, Vos PE, Veerbek MM, de Haan RJ: PROPAC Study Group. Prediction of poor outcome within the first 3 days of postanoxic coma. Neurology. 2006, 66: 62-68. 10.1212/01.wnl.0000191308.22233.88.CrossRefPubMed
16.
17.
go back to reference Topcuoglu MA, Oguz KK, Buyukserbetci G, Bulut E: Prognostic value of magnetic resonance imaging in post-resuscitation encephalopathy. Intern Med. 2009, 48: 1635-1645. 10.2169/internalmedicine.48.2091.CrossRefPubMed Topcuoglu MA, Oguz KK, Buyukserbetci G, Bulut E: Prognostic value of magnetic resonance imaging in post-resuscitation encephalopathy. Intern Med. 2009, 48: 1635-1645. 10.2169/internalmedicine.48.2091.CrossRefPubMed
18.
go back to reference Wijman CAC, Mlynash M, Caulfield AF, Eyngorm I, Bammer R, Fishbein N, Albers GW, Moseley M: Prognostic value of brain diffusion weighted imaging after cardiac arrest. Ann Neurol. 2009, 65: 349-402.CrossRef Wijman CAC, Mlynash M, Caulfield AF, Eyngorm I, Bammer R, Fishbein N, Albers GW, Moseley M: Prognostic value of brain diffusion weighted imaging after cardiac arrest. Ann Neurol. 2009, 65: 349-402.CrossRef
19.
go back to reference Arbalaez A, Castillo M, Mukherij SK: Diffusion-weighted MR Imaging of global cerebral anoxia. Am J Neuroradiol. 1999, 20: 999-1007. Arbalaez A, Castillo M, Mukherij SK: Diffusion-weighted MR Imaging of global cerebral anoxia. Am J Neuroradiol. 1999, 20: 999-1007.
20.
go back to reference Greer DM: Unexpected good recovery in a comatose post-cardiac arrest patient with poor prognostic features. Resuscitation. 2013, 84: e81-82. 10.1016/j.resuscitation.2013.02.011.CrossRefPubMed Greer DM: Unexpected good recovery in a comatose post-cardiac arrest patient with poor prognostic features. Resuscitation. 2013, 84: e81-82. 10.1016/j.resuscitation.2013.02.011.CrossRefPubMed
21.
go back to reference Kulkarni B, Bentley DE, Elliott R, Bentley DE, Elliott R, Youell P, Derbyshire SWG, Frackowiack RSJ, Friston KJ, Jones AKP: Attention to pain localization and unpleasantness determines the functions of the medial and lateral pain systems. Eur J Neurosci. 2005, 21: 3133-3142. 10.1111/j.1460-9568.2005.04098.x.CrossRefPubMed Kulkarni B, Bentley DE, Elliott R, Bentley DE, Elliott R, Youell P, Derbyshire SWG, Frackowiack RSJ, Friston KJ, Jones AKP: Attention to pain localization and unpleasantness determines the functions of the medial and lateral pain systems. Eur J Neurosci. 2005, 21: 3133-3142. 10.1111/j.1460-9568.2005.04098.x.CrossRefPubMed
22.
go back to reference Ploner M, Freund HJ, Schnitzler A: Pain affect without pain sensation in a patient with a postcentral lesion. Pain. 1999, 81: 211-214. 10.1016/S0304-3959(99)00012-3.CrossRefPubMed Ploner M, Freund HJ, Schnitzler A: Pain affect without pain sensation in a patient with a postcentral lesion. Pain. 1999, 81: 211-214. 10.1016/S0304-3959(99)00012-3.CrossRefPubMed
23.
go back to reference Mao CC, Coull BM, Golpher LAC, Rau MT: Anterior operculum syndrome. Neurology. 1989, 39: 1169-1172. 10.1212/WNL.39.9.1169.CrossRefPubMed Mao CC, Coull BM, Golpher LAC, Rau MT: Anterior operculum syndrome. Neurology. 1989, 39: 1169-1172. 10.1212/WNL.39.9.1169.CrossRefPubMed
24.
go back to reference Overgaard M: How can we know if patients in coma, vegetative state or minimally conscious state are conscious. Prog Brain Res. 2009, 177: 11-19.CrossRefPubMed Overgaard M: How can we know if patients in coma, vegetative state or minimally conscious state are conscious. Prog Brain Res. 2009, 177: 11-19.CrossRefPubMed
Metadata
Title
Cerebral hypoxia, missing cortical somatosensory evoked potentials and recovery of consciousness
Authors
Gustav Pfeiffer
Rüdiger Pfeifer
Stefan Isenmann
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2014
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-14-82

Other articles of this Issue 1/2014

BMC Neurology 1/2014 Go to the issue