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BMC Neurology
Published in: BMC Neurology 1/2013

Open Access 01-12-2013 | Research article

Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring

Authors: Enrique Alcalde-Cabero, Javier Almazán-Isla, Antonio García-Merino, Joao de Sá, Jesús de Pedro-Cuesta

Published in: BMC Neurology | Issue 1/2013

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Abstract

Background

A debate surrounding multiple sclerosis epidemiology has centred on time-related incidence increases and the need of monitoring. The purpose of this study is to reassess multiple sclerosis incidence in the European Economic Area.

Methods

We conducted a systematic review of literature from 1965 onwards and integrated elements of original research, including requested or completed data by surveys authors and specific analyses.

Results

The review of 5323 documents yielded ten studies for age- and sex-specific analyses, and 21 studies for time-trend analysis of single data sets. After 1985, the incidence of multiple sclerosis ranged from 1.12 to 6.96 per 100,000 population, was higher in females, tripled with latitude, and doubled with study midpoint year. The north registered increasing trends from the 1960s and 1970s, with a historic drop in the Faroe Islands, and fairly stable data in the period 1980-2000; incidence rose in Italian and French populations in the period 1970-2000, in Evros (Greece) in the 1980s, and in the French West Indies in around 2000.

Conclusions

We conclude that the increase in multiple sclerosis incidence is only apparent, and that it is not specific to women. Monitoring of multiple sclerosis incidence might be appropriate for the European Economic Area.
Appendix
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Metadata
Title
Incidence of multiple sclerosis among European Economic Area populations, 1985-2009: the framework for monitoring
Authors
Enrique Alcalde-Cabero
Javier Almazán-Isla
Antonio García-Merino
Joao de Sá
Jesús de Pedro-Cuesta
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2013
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-13-58

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