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BMC Medical Genetics
Published in: BMC Medical Genetics 1/2007

Open Access 01-12-2007 | Study protocol

The Fangshan/Family-based Ischemic Stroke Study In China (FISSIC) protocol

Authors: Xun Tang, Yonghua Hu, Dafang Chen, Siyan Zhan, Zongxin Zhang, Huidong Dou

Published in: BMC Medical Genetics | Issue 1/2007

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Abstract

Background

The exact etiology of ischemic stroke remains unclear, because multiple genetic predispositions and environmental risk factors may be involved, and their interactions dictate the complexity. Family-based studies provide unique features in design, while they are currently underrepresented for studies of ischemic stroke in developing countries. The Fangshan/Family-based Ischemic Stroke Study In China (FISSIC) program aims to conduct a genetic pedigree study of ischemic stroke in rural communities of China.

Methods/Design

The pedigrees of ischemic stroke with clear documentation are recruited by using the proband-initiated contact method, based on the stroke registry in hospital and communities. Blood samples and detailed information of pedigrees are collected through the health care network in the rural area, and prospective follow-up of the pedigrees cohort is scheduled. Complementary strategies of both family-based design and matched case-spousal control design are used, and comprehensive statistical methods will be implemented to ascertain potential complex genetic and environmental factors and their interactions as well.

Discussion

This study is complementary to other genetic pedigree studies of ischemic stroke, such as the Siblings With Ischemic Stroke Study (SWISS), which are established in developed countries. We describe the protocol of this family-based genetic epidemiological study that may be used as a new practical guideline and research paradigm in developing countries and facilitate initiatives of stroke study for international collaborations.
Appendix
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Metadata
Title
The Fangshan/Family-based Ischemic Stroke Study In China (FISSIC) protocol
Authors
Xun Tang
Yonghua Hu
Dafang Chen
Siyan Zhan
Zongxin Zhang
Huidong Dou
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2007
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/1471-2350-8-60

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