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BMC Medical Genetics

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Open Access 01-12-2009 | Research article

Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study

Authors: Ahlem Saadi, Guimin Gao, Huaichen Li, Chunhua Wei, Yaoqin Gong, Qiji Liu

Published in: BMC Medical Genetics | Issue 1/2009

Abstract

Background

Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Importantly, variants in the VDR gene have been susceptible in the past to raise the risk of asthma in several populations. These effects of VDR allelic markers remain speculative in the Chinese Han population.

Results

A case-control study of 1090 individuals including 567 asthmatic patients was realized on five SNPs within the VDR gene. Only rs7975232 (ApaI) marker showed a significant association with asthma (P = 0.009). Haplotype analysis of the five VDR polymorphisms showed a significant association with asthma (global-p value = 0.012).

Conclusion

Although the susceptibility of VDR gene variants with asthma could not be confirmed for all SNPs tested in this study, the significant association obtained for rs7975232 provides evidence for a previously unknown report about the Chinese Han population and may raise the susceptibility of VDR to be a candidate gene for asthma.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/10/71/prepub

Title: Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study
Authors: Ahlem Saadi
Guimin Gao
Huaichen Li
Chunhua Wei
Yaoqin Gong
Qiji Liu
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2009
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/1471-2350-10-71

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study

Abstract

Background

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusion

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