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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2011

Open Access 01-12-2011 | Research article

In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice

Authors: Hong-Mei Ren, Li-Qun Yang, Zhi-Qiang Liu, Cai-Yang Chen, Chi-Wai Cheung, Kun-Ming Tao, Jian-Gang Song, Wu-Rong Chen, Wei-Feng Yu

Published in: BMC Gastroenterology | Issue 1/2011

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Abstract

Background

Responsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.

Methods

Male Sprague-Dawley rats (n = 40) were randomly allocated into two groups, twenty underwent bile duct ligation (BDL), and 20 underwent a sham operation. Seven days after the surgery, propofol was administered in vivo and ex vivo (Langendorff preparations). Heart rate, left ventricular end-systolic pressure (LVESP) left ventricular end-diastolic pressure (LVEDP), and maximal rate for left ventricular pressure rise and decline (± dP/dtmax ) were measured to determine the influence of propofol on the cardiac function of rats.

Results

Impaired basal cardiac function was observed in the isolated BDL hearts, whereas in vivo indices of basal cardiac function (LVESP and ± dP/dt) in vivo were significantly higher in rats that underwent BDL compared with controls. With low or intermediate concentrations of propofol, these indices of cardiac function were within the normal physiologic range in both groups, and responsiveness to propofol was unaffected by BDL. When the highest concentration of propofol was administrated, a significant decline in cardiac function was observed in the BDL group.

Conclusions

In rats that underwent BDL, basal cardiac performance was better in vivo and worse ex vivo compared with controls. Low and intermediate concentrations of propofol did not appear to impair cardiac function in rats with obstructive jaundice.
Appendix
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Metadata
Title
In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice
Authors
Hong-Mei Ren
Li-Qun Yang
Zhi-Qiang Liu
Cai-Yang Chen
Chi-Wai Cheung
Kun-Ming Tao
Jian-Gang Song
Wu-Rong Chen
Wei-Feng Yu
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2011
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/1471-230X-11-144

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