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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2010

Open Access 01-12-2010 | Research article

Combined sedation with midazolam/propofol for gastrointestinal endoscopy in elderly patients

Authors: Astrid Kerker, Christian Hardt, Hans-Eugen Schlief, Franz Ludwig Dumoulin

Published in: BMC Gastroenterology | Issue 1/2010

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Abstract

Background

Although gastrointestinal endoscopy with sedation is increasingly performed in elderly patients, data on combined sedation with midazolam/propofol are very limited for this age group.

Methods

We retrospectively analyzed 454 endoscopic procedures in 347 hospitalized patients ≥ 70 years who had received combined sedation with midazolam/propofol. 513 endoscopic procedures in 397 hospitalized patients < 70 years during the observation period served as controls. Characteristics of endoscopic procedures, co-morbidity, complications and mortality were compared.

Results

Elderly patients had a higher level of co-morbidity and needed lower mean propofol doses for sedation. We observed no major complication and no difference in the number of minor complications. The procedure-associated mortality was 0%; the 28-day mortality was significantly higher in the elderly (2.9% vs. 1.0%).

Conclusions

In this study on elderly patients with high level co-morbidity, a favourable safety profile was observed for a combined sedation with midazolam/propofol with a higher sensitivity to propofol in the elderly.
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Metadata
Title
Combined sedation with midazolam/propofol for gastrointestinal endoscopy in elderly patients
Authors
Astrid Kerker
Christian Hardt
Hans-Eugen Schlief
Franz Ludwig Dumoulin
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2010
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/1471-230X-10-11

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