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BMC Medical Research Methodology
Published in: BMC Medical Research Methodology 1/2009

Open Access 01-12-2009 | Research article

Bias in odds ratios by logistic regression modelling and sample size

Authors: Szilard Nemes, Junmei Miao Jonasson, Anna Genell, Gunnar Steineck

Published in: BMC Medical Research Methodology | Issue 1/2009

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Abstract

Background

In epidemiological studies researchers use logistic regression as an analytical tool to study the association of a binary outcome to a set of possible exposures.

Methods

Using a simulation study we illustrate how the analytically derived bias of odds ratios modelling in logistic regression varies as a function of the sample size.

Results

Logistic regression overestimates odds ratios in studies with small to moderate samples size. The small sample size induced bias is a systematic one, bias away from null. Regression coefficient estimates shifts away from zero, odds ratios from one.

Conclusion

If several small studies are pooled without consideration of the bias introduced by the inherent mathematical properties of the logistic regression model, researchers may be mislead to erroneous interpretation of the results.
Appendix
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Metadata
Title
Bias in odds ratios by logistic regression modelling and sample size
Authors
Szilard Nemes
Junmei Miao Jonasson
Anna Genell
Gunnar Steineck
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Medical Research Methodology / Issue 1/2009
Electronic ISSN: 1471-2288
DOI
https://doi.org/10.1186/1471-2288-9-56

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