Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2013

Open Access 01-12-2013 | Letter to the Editor

Migraine, arousal and sleep deprivation: comment on: “sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study”

Authors: Catello Vollono, Elisa Testani, Anna Losurdo, Salvatore Mazza, Giacomo Della Marca

Published in: The Journal of Headache and Pain | Issue 1/2013

Login to get access

Abstract

We discuss the hypothesis proposed by Engstrom and coworkers that Migraineurs have a relative sleep deprivation, which lowers the pain threshold and predispose to attacks. Previous data indicate that Migraineurs have a reduction of Cyclic Alternating Pattern (CAP), an essential mechanism of NREM sleep regulation which allows to dump the effect of incoming disruptive stimuli, and to protect sleep. The modifications of CAP observed in Migraineurs are similar to those observed in patients with impaired arousal (narcolepsy) and after sleep deprivation. The impairment of this mechanism makes Migraineurs more vulnerable to stimuli triggering attacks during sleep, and represents part of a more general vulnerability to incoming stimuli.
Literature
1.
Engstrom M, Hagen K, Bjork MH, Stovner LJ, Gravdahl GB, Stjern M, Sand T: Sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study. The journal of headache and pain 2013,14(1):12. 10.1186/1129-2377-14-12PubMedCentralPubMedCrossRef
2.
Onen SH, Alloui A, Gross A, Eschallier A, Dubray C: The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects. J Sleep Res 2001,10(1):35–42. 10.1046/j.1365-2869.2001.00240.xPubMedCrossRef
3.
Andress-Rothrock D, King W, Rothrock J: An analysis of migraine triggers in a clinic-based population. Headache 2010,50(8):1366–1370. 10.1111/j.1526-4610.2010.01753.xPubMedCrossRef
4.
Smith MT, Edwards RR, McCann UD, Haythornthwaite JA: The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep 2007,30(4):494–505.PubMed
5.
Della Marca G, Vollono C, Rubino M, Di Trapani G, Mariotti P, Tonali PA: Dysfunction of arousal systems in sleep-related migraine without aura. Cephalalgia: an international journal of headache 2006,26(7):857–864.CrossRef
6.
Poryazova R, Werth E, Parrino L, Terzano MG, Bassetti CL: Cyclic alternating pattern in narcolepsy patients and healthy controls after partial and total sleep deprivation. Clin Neurophysiol: official journal of the International Federation of Clinical Neurophysiology 2011,122(9):1788–1793. 10.1016/j.clinph.2011.02.028CrossRef
7.
Borsook D, Maleki N, Becerra L, McEwen B: Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load. Neuron 2012,73(2):219–234. 10.1016/j.neuron.2012.01.001PubMedCrossRef
Metadata
Title
Migraine, arousal and sleep deprivation: comment on: “sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study”
Authors
Catello Vollono
Elisa Testani
Anna Losurdo
Salvatore Mazza
Giacomo Della Marca
Publication date
01-12-2013
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-14-50

Other articles of this Issue 1/2013

The Journal of Headache and Pain 1/2013 Go to the issue

Editorial

Migraine: the seventh disabler

Research article

Sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study

Research article

Lateral inhibition in visual cortex of migraine patients between attacks

Research article

Management of secondary chronic headache in the general population: the Akershus study of chronic headache

Case report

Spontaneous intracerebral hemorrhage in CADASIL

Review article

Triptans in prevention of menstrual migraine: a systematic review with meta-analysis