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Current Oral Health Reports
Published in: Current Oral Health Reports 4/2015

Open Access 01-12-2015 | Stem-cell Biology for Tooth and Periodontal Regeneration (M Bartold, Section Editor)

Induced Pluripotent Stem Cells and Periodontal Regeneration

Authors: Mi Du, Xuejing Duan, Pishan Yang

Published in: Current Oral Health Reports | Issue 4/2015

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Abstract

Periodontitis is a chronic inflammatory disease which leads to destruction of both the soft and hard tissues of the periodontium. Tissue engineering is a therapeutic approach in regenerative medicine that aims to induce new functional tissue regeneration via the synergistic combination of cells, biomaterials, and/or growth factors. Advances in our understanding of the biology of stem cells, including embryonic stem cells and mesenchymal stem cells, have provided opportunities for periodontal tissue engineering. However, there remain a number of limitations affecting their therapeutic efficiency. Due to the considerable proliferation and differentiation capacities, recently described induced pluripotent stem cells (iPSCs) provide a new way for cell-based therapies for periodontal regeneration. This review outlines the latest status of periodontal tissue engineering and highlights the potential use of iPSCs in periodontal tissue regeneration.
Literature
1.••
Han J et al. Stem cells, tissue engineering and periodontal regeneration. Aust Dent J. 2014;59 Suppl 1:117–30. This manuscript summarized stems cells used in periodontal tissue engineering.CrossRefPubMed
2.
Sander L, Karring T. Healing of periodontal lesions in monkeys following the guided tissue regeneration procedure. A histological study. J Clin Periodontol. 1995;22(4):332–7.CrossRefPubMed
3.
Bartold PM et al. Principles and applications of cell delivery systems for periodontal regeneration. Periodontol 2000. 2006;41:123–35.CrossRefPubMed
4.
Tobita M et al. Periodontal tissue regeneration with adipose-derived stem cells. Tissue Eng A. 2008;14:945–53.CrossRef
5.
Hynes K, Gronthos S, Bartold PM. iPSC for dental tissue regeneration. Curr Oral Health Rep. 2014;1(1):9–15.CrossRef
6.
7.
Shakir S et al. Transforming growth factor beta 1 augments calvarial defect healing and promotes suture regeneration. Tissue Eng A. 2015;21(5–6):939–47.CrossRef
8.
Woo KM et al. Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials. 2007;28(2):335–43.CrossRefPubMed
9.
Woo KM, Chen VJ, Ma PX. Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res A. 2003;67(2):531–7.CrossRefPubMed
10.
Mustafa K et al. The influence of surface topography of ceramic abutments on the attachment and proliferation of human oral fibroblasts. Biomaterials. 2005;26(4):373–81.CrossRefPubMed
11.
Christoph A et al. Advanced regenerative technologies for periodontal tissue repair. Periodontol 2000. 2012;59(1):185–202.CrossRef
12.
Gonçalves PF et al. Effect of two different approaches for root decontamination on new cementum formation following guided tissue regeneration: a histomorphometric study in dogs. J Periodontal Res. 2006;41(6):535–40.CrossRefPubMed
13.
Hoffmann T et al. A randomized clinical multi-centre trial comparing enamel matrix derivative and membrane treatment of buccal class II furcation involvement in mandibular molars. Part III: patient factors and treatment outcome. J Clin Periodontol. 2006;33(8):575–83.CrossRefPubMed
14.
15.
Vo TN, Kasper FK, Mikos AG. Strategies for controlled delivery of growth factors and cells for bone regeneration. Adv Drug Deliv Rev. 2012;64(12):1292–309.PubMedCentralCrossRefPubMed
16.
Du L, Yang P, Ge S. Stromal cell-derived factor-1 significantly induces proliferation, migration, and collagen type I expression in a human periodontal ligament stem cell subpopulation. J Periodontol. 2012;83(3):379–88.CrossRefPubMed
17.
Knight MN, Hankenson KD. Mesenchymal stem cells in bone regeneration. Adv Wound Care (New Rochelle). 2013;2(6):306–16.CrossRef
18.
Chen FM et al. Homing of endogenous stem/progenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives. Biomaterials. 2011;32(12):3189–209.CrossRefPubMed
19.
Lau TT, Wang DA. Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin Biol Ther. 2011;11(2):189–97.CrossRefPubMed
20.
Schmidt A et al. Basic fibroblast growth factor controls migration in human mesenchymal stem cells. Stem Cells. 2006;24(7):1750–8.CrossRefPubMed
21.
Tasso R et al. The role of bFGF on the ability of MSC to activate endogenous regenerative mechanisms in an ectopic bone formation model. Biomaterials. 2012;33(7):2086–96.CrossRefPubMed
22.
Bianchi G et al. Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp Cell Res. 2003;287(1):98–105.CrossRefPubMed
23.
Rodan SB et al. Effects of acidic and basic fibroblast growth factors on osteoblastic cells. Connect Tissue Res. 1989;20(1–4):283–8.CrossRefPubMed
24.
Thesleff I, Tummers M. Stem cells and tissue engineering: prospects for regenerating tissues in dental practice. Med Princ Pract. 2003;12 Suppl 1:43–50.CrossRefPubMed
25.
Inanç B, Elçin AE, Elçin YM. In vitro differentiation and attachment of human embryonic stem cells on periodontal tooth root surfaces. Tissue Eng A. 2009;15(11):3427–35.CrossRef
26.
Elçin YM, Inanç B, Elçin AE. Human embryonic stem cell differentiation on periodontal ligament fibroblasts. Methods Mol Biol. 2010;584:269–81.CrossRefPubMed
27.
Yang YR et al. Transplantation of embryonic stem cells improves the regeneration of periodontal furcation defects in a porcine model. J Clin Periodontol. 2013;40(4):364–71.CrossRefPubMed
28.
Mosher JT et al. Lack of population diversity in commonly used human embryonic stem-cell lines. N Engl J Med. 2010;362(2):183–5.CrossRefPubMed
29.
Swijnenburg RJ et al. In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation. Stem Cells Dev. 2008;17(6):1023–9.PubMedCentralCrossRefPubMed
30.
Robey PG et al. Generation of clinical grade human bone marrow stromal cells for use in bone regeneration. Bone. 2015;70:87–92.CrossRefPubMed
31.
32.
Lian Q et al. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation. 2010;121(9):1113–23.CrossRefPubMed
33.
34.
Katsara O et al. Effects of donor age, gender, and in vitro cellular aging on the phenotypic, functional, and molecular characteristics of mouse bone marrow-derived mesenchymal stem cells. Stem Cells. 2011;20(9):1549–61.CrossRef
35.
Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem. 2001;82(4):583–90.CrossRefPubMed
36.
Mendes SC et al. Bone tissue-engineered implants using human bone marrow stromal cells: effect of culture conditions and donor age. Tissue Eng. 2002;8(6):911–20.CrossRefPubMed
37.
Rodriguez JP et al. Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation. J Cell Biochem. 2000;79(4):557–65.CrossRefPubMed
38.
Suzuki Y et al. Stromal cell activity in bone marrow from the tibia and iliac crest of patients with rheumatoid arthritis. J Bone Miner Metab. 2001;19(1):56–60.CrossRefPubMed
39.
Bo Q et al. Human mesenchymal stem cells as delivery of osteoprotegerin gene: homing and therapeutic effect for osteosarcoma. Drug Des Devel Ther. 2015;9:969–76.
40.
Diptiman C et al. Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton. J Cell Biochem. 2010;111(2):249–57.CrossRef
41.
Krishna KK et al. Mesenchymal stem cells as vectors for lung cancer therapy. Respiration. 2013;85(6):443–51.CrossRef
42.
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–76.CrossRefPubMed
43.
Takahashi K et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–72.CrossRefPubMed
44.
45.
Yu J et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318(5858):1917–20.CrossRefPubMed
46.
47.
Marchetto MC et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010;143(4):527–39.PubMedCentralCrossRefPubMed
48.
49.
Tamaoki N et al. Dental pulp cells for induced pluripotent stem cell banking. J Dent Res. 2010;89(8):773–8.CrossRefPubMed
50.
Wada N et al. Induced pluripotent stem cell lines derived from human gingival fibroblasts and periodontal ligament fibroblasts. J Periodontal Res. 2011;46(4):438–47.CrossRefPubMed
51.
Nomura Y et al. Human periodontal ligament fibroblasts are the optimal cell source for induced pluripotent stem cells. Histochem Cell Biol. 2012;137(6):719–32.CrossRefPubMed
52.
Hou P et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013;341(6146):651–4.CrossRefPubMed
53.
Nakagawa M et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol. 2008;26(1):101–6.CrossRefPubMed
54.
55.
56.••
Hu KJ. All roads lead to induced pluripotent stem cells: the technologies of iPSC generation. Stem Cells Dev. 2014;23(12):1285–300. This systematic review summarized the ways for inducing iPSCs.PubMedCentralCrossRefPubMed
57.
58.
Zhou H et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell. 2009;4(5):381–4.CrossRefPubMed
59.
Cho HJ et al. Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation. Blood. 2010;116(3):386–95.CrossRefPubMed
60.
Ru Z et al. iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacol Sin. 2013;34(6):765–76.CrossRef
61.
Feng B et al. Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell. 2009;4(4):301–12.CrossRefPubMed
62.
Zhou W, Freed CR. Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells. 2009;27(11):2667–74.CrossRefPubMed
63.
64.
Fusaki N et al. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci. 2009;85(8):348–62.PubMedCentralCrossRefPubMed
65.
Warren L et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010;7(5):618–30.PubMedCentralCrossRefPubMed
66.
67.
Ding S et al. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell. 2005;122(3):473–83.CrossRefPubMed
68.
Geurts AM et al. Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet. 2006;2(9), e156.PubMedCentralCrossRefPubMed
69.
Kazim H et al. Generation of adult human induced pluripotent stem cells using non-viral minicircle DNA vectors. Nat Protoc. 2011;6(1):78–88.
70.
Anokye-Danso F et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell. 2011;8(4):376–88.PubMedCentralCrossRefPubMed
71.
Miyoshi N et al. Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell. 2011;8(6):633–8.CrossRefPubMed
72.
73.
Zhang R, Zhang LH, Xie X. iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacol Sin. 2013;34(6):765–76.PubMedCentralCrossRefPubMed
74.
Huangfu D et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol. 2008;26(7):795–7.CrossRefPubMed
75.
Novak A et al. Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus. Cell Reprogramming. 2010;12(6):665–78.CrossRef
76.
77.
78.
Aasen T et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol. 2008;26(11):1276–84.CrossRefPubMed
79.
Maetzel D et al. Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick type C patient-specific iPS cells. Stem Cell Rep. 2014;2(6):866–80.CrossRef
80.
Eggenschwiler R et al. Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy. Stem Cells Transl Med. 2013;2(9):641–54.PubMedCentralCrossRefPubMed
81.
Reinhardt P et al. Genetic correction of a lrrk2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Cell Stem Cell. 2013;12(3):354–67.CrossRefPubMed
82.
Egusa H et al. Comparative analysis of mouse-induced pluripotent stem cells and mesenchymal stem cells during osteogenic differentiation in vitro. Stem Cells Dev. 2014;23(18):2156–69.PubMedCentralCrossRefPubMed
83.
Diederichs S, Tuan RS. Functional comparison of human-induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor. Stem Cells Dev. 2014;23(14):1594–610.PubMedCentralCrossRefPubMed
84.
Li F, Niyibizi C. Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo. BMC Cell Biol. 2012;13:35.PubMedCentralCrossRefPubMed
85.•
Duan XJ et al. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. J Cell Physiol. 2011;226(1):150–7. This manuscript firstly reported the application of iPSCs in periodontal regeneration.PubMedCentralCrossRefPubMed
86.
Polimeni G et al. Histopathological observations of a polylactic acid-based device intended for guided bone/tissue regeneration. Clin Implant Dent Relat Res. 2008;10(2):99–105.CrossRefPubMed
87.
Sculean A, Nikolidakis D, Schwarz F. Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials—biological foundation and preclinical evidence: a systematic review. J Clin Periodontol. 2008;35(Suppl):106–16.CrossRefPubMed
88.•
Hynes K et al. Mesenchymal stem cells from iPS cells facilitate periodontal regeneration. J Dent Res. 2013;92(9):833–9. This manuscript firstly described MSCs derived from iPSCs can facilitate periodontal regeneration.CrossRefPubMed
89.
Yang H et al. Therapeutic effect of TSG-6 engineered iPSC-derived MSCs on experimental periodontitis in rats: a pilot study. PLoS One. 2014;9(6), e100285.PubMedCentralCrossRefPubMed
90.
Zhao Y et al. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell. 2008;3(5):475–9.CrossRefPubMed
91.
Zhumur G et al. Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One. 2010;5(2), e8975.CrossRef
92.
93.
Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature. 2007;448(7151):313–7.CrossRefPubMed
94.
95.
Ben-David U, Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer. 2011;11(4):268–77.CrossRefPubMed
96.
Metadata
Title
Induced Pluripotent Stem Cells and Periodontal Regeneration
Authors
Mi Du
Xuejing Duan
Pishan Yang
Publication date
01-12-2015
Publisher
Springer International Publishing
Published in
Current Oral Health Reports / Issue 4/2015
Electronic ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-015-0065-8

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