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Current Oral Health Reports
Published in: Current Oral Health Reports 2/2014

01-06-2014 | Immunology (G Nussbaum, Section Editor)

Neutrophil Dysfunction and Host Susceptibility to Periodontal Inflammation: Current State of Knowledge

Authors: Corneliu Sima, Michael Glogauer

Published in: Current Oral Health Reports | Issue 2/2014

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Abstract

Normal polymorphonuclear neutrophil (PMN) function is critical for the maintenance of host-biofilm equilibrium and periodontal tissue homeostasis. Mounting evidence suggests that PMNs play important roles in the control of commensal periodontal flora and initiation of resolution following inflammation caused by accumulating subgingival plaque. Quantitative and qualitative alterations of PMNs in bone marrow, blood, periodontal tissues, and gingival crevicular fluid contribute to host-microbial dysbiosis and onset of irreversible loss of clinical attachment around teeth. Recent findings of specific PMN phenotypes associated with different disease states bring us closer to understanding disease activity and addressing chronic, non-resolved, periodontal inflammation to better monitor and predict patient-specific treatment outcomes. The present review addresses the current state of knowledge in PMN biology in the pathogenesis of periodontal inflammation and the onset of periodontitis.
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Metadata
Title
Neutrophil Dysfunction and Host Susceptibility to Periodontal Inflammation: Current State of Knowledge
Authors
Corneliu Sima
Michael Glogauer
Publication date
01-06-2014
Publisher
Springer International Publishing
Published in
Current Oral Health Reports / Issue 2/2014
Electronic ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-014-0015-x

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