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Current Oral Health Reports
Published in: Current Oral Health Reports 2/2014

01-06-2014 | Oral Cancer (A Le, Section Editor)

Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances

Authors: Maha Yakob, Laurel Fuentes, Marilene B. Wang, Elliot Abemayor, David T.W. Wong

Published in: Current Oral Health Reports | Issue 2/2014

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Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Detection of OSCC is currently based on a thorough clinical oral examination combined with a biopsy for histological analysis. Most cases of OSCC are not detected until the cancer has developed into advanced stages; thus, a reliable early-stage diagnostic marker is needed. This literature review presents an overview of the status of current advances in salivary diagnostics for OSCC. Though many protein and mRNA salivary biomarkers have been identified that can detect OSCC with high sensitivity and specificity, the most discernable findings occur with the use of multiple markers. Studies that incorporate proteomic, transcriptomic, and potentially additional “omics”, including methylomics, need to be initiated to bring technology to clinical applications and allow the best use of saliva in diagnosing OSCC.
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Metadata
Title
Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances
Authors
Maha Yakob
Laurel Fuentes
Marilene B. Wang
Elliot Abemayor
David T.W. Wong
Publication date
01-06-2014
Publisher
Springer International Publishing
Published in
Current Oral Health Reports / Issue 2/2014
Electronic ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-014-0014-y

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