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Published in: Sports Medicine 1/2019

01-01-2019 | Systematic Review

Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-Analysis

Authors: Cayque Brietzke, Paulo Estevão Franco-Alvarenga, Hélio José Coelho-Júnior, Rodrigo Silveira, Ricardo Yukio Asano, Flávio Oliveira Pires

Published in: Sports Medicine | Issue 1/2019

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Abstract

Background

Despite the growing number of studies reporting carbohydrate mouth rinse effects on endurance performance, no systematic and meta-analysis review has been conducted to elucidate the level of evidence of carbohydrate mouth rinse effects on cycling trial performance such as time-, work-, and distance-based trials.

Objectives

The objective of this study were to establish the effect of a carbohydrate mouth rinse on cycling performance outcomes such as mean power output and time to complete a trial, together with the risk of bias in the cycling-carbohydrate mouth rinse literature.

Methods

We systematically reviewed randomized placebo-controlled trials that assessed carbohydrate mouth rinse effects on mean power output and time to complete the trial. A random-effects meta-analysis assessed the standardized mean difference between carbohydrate and placebo mouth rinses.

Results

Thirteen studies (16 trials) were qualitatively (systematic review) and quantitatively (meta-analysis) analyzed with regard to mean power output (n = 175) and time to complete the trial (n = 151). Overall, the reviewed studies showed a low risk of bias and homogeneous results for mean power output (I2 = 0%) and time to complete the trial (I2 = 0%). When compared with placebo, the carbohydrate mouth rinse improved mean power output (standardized mean difference = 0.25; 95% confidence interval 0.04–0.46; p = 0.02), but not the time to complete the trial (standardized mean difference = − 0.13; 95% confidence interval − 0.36 to 0.10; p = 0.25).

Conclusion

The present systematic and meta-analytic review supports the notion that a carbohydrate mouth rinse has the potential to increase mean power output in cycling trials, despite showing no superiority over placebo in improving time to complete the trials.
Appendix
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Literature
1.
go back to reference Carter JM, Jeukendrup AE, Jones DA. The effect of carbohydrate mouth rinse on 1-h cycle time trial performance. Med Sci Sports Exerc. 2004;36:2107–11.CrossRefPubMed Carter JM, Jeukendrup AE, Jones DA. The effect of carbohydrate mouth rinse on 1-h cycle time trial performance. Med Sci Sports Exerc. 2004;36:2107–11.CrossRefPubMed
2.
go back to reference Thomas DT, Erdman KA, Burke LM. Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: nutrition and athletic performance. J Acad Nutr Diet. 2016;116:501–28.CrossRefPubMed Thomas DT, Erdman KA, Burke LM. Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: nutrition and athletic performance. J Acad Nutr Diet. 2016;116:501–28.CrossRefPubMed
3.
go back to reference Chambers ES, Bridge MW, Jones DA. Carbohydrate sensing in the human mouth: effects on exercise performance and brain activity. J Physiol. 2009;587:1779–94.CrossRefPubMedPubMedCentral Chambers ES, Bridge MW, Jones DA. Carbohydrate sensing in the human mouth: effects on exercise performance and brain activity. J Physiol. 2009;587:1779–94.CrossRefPubMedPubMedCentral
4.
go back to reference Devenney S, Collins K, Shortall M. Effects of various concentrations of carbohydrate mouth rinse on cycling performance in a fed state. Eur J Sport Sci. 2016;16:1073–8.CrossRefPubMed Devenney S, Collins K, Shortall M. Effects of various concentrations of carbohydrate mouth rinse on cycling performance in a fed state. Eur J Sport Sci. 2016;16:1073–8.CrossRefPubMed
5.
go back to reference James RM, Ritchie S, Rollo I, James LJ. No dose response effect of carbohydrate mouth rinse on cycling time-trial performance. Int J Sport Nutr Exerc Metab. 2017;27:25–31.CrossRefPubMed James RM, Ritchie S, Rollo I, James LJ. No dose response effect of carbohydrate mouth rinse on cycling time-trial performance. Int J Sport Nutr Exerc Metab. 2017;27:25–31.CrossRefPubMed
6.
go back to reference Tsintzas OK, Williams C, Boobis L, Greenhaff P. Carbohydrate ingestion and glycogen utilization in different muscle fibre types in man. J Physiol. 1995;489:243–50.CrossRefPubMedPubMedCentral Tsintzas OK, Williams C, Boobis L, Greenhaff P. Carbohydrate ingestion and glycogen utilization in different muscle fibre types in man. J Physiol. 1995;489:243–50.CrossRefPubMedPubMedCentral
7.
go back to reference Coyle EF, Coggan AR, Hemmert MK, Ivy JL. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol. 1986;61:165–72.CrossRefPubMed Coyle EF, Coggan AR, Hemmert MK, Ivy JL. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol. 1986;61:165–72.CrossRefPubMed
8.
go back to reference Hargreaves M, Costill DL, Coggan A, Fink WJ, Nishibata I. Effect of carbohydrate feedings on muscle glycogen utilization and exercise performance. Med Sci Sport Exerc. 1984;16:219–22. Hargreaves M, Costill DL, Coggan A, Fink WJ, Nishibata I. Effect of carbohydrate feedings on muscle glycogen utilization and exercise performance. Med Sci Sport Exerc. 1984;16:219–22.
9.
go back to reference Robertson CV, Marino FE. A role for the prefrontal cortex in exercise tolerance and termination. J Appl Physiol. 2016;120:464–6.CrossRefPubMed Robertson CV, Marino FE. A role for the prefrontal cortex in exercise tolerance and termination. J Appl Physiol. 2016;120:464–6.CrossRefPubMed
10.
go back to reference Turner CE, Byblow WD, Gant N. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. J Neurosci. 2015;35:1773–80.CrossRefPubMedPubMedCentral Turner CE, Byblow WD, Gant N. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. J Neurosci. 2015;35:1773–80.CrossRefPubMedPubMedCentral
11.
go back to reference Ataide-Silva T, Ghiarone T, Bertuzzi R, Stathis CG, Leandro CG, Lima-Silva AE. CHO mouth rinse ameliorates neuromuscular response with lower endogenous CHO stores. Med Sci Sports Exerc. 2016;48:1810–20.CrossRefPubMed Ataide-Silva T, Ghiarone T, Bertuzzi R, Stathis CG, Leandro CG, Lima-Silva AE. CHO mouth rinse ameliorates neuromuscular response with lower endogenous CHO stores. Med Sci Sports Exerc. 2016;48:1810–20.CrossRefPubMed
12.
go back to reference Bastos-Silva VJ, Melo Ade A, Lima-Silva AE, Moura FA, Bertuzzi R, de Araujo GG. Carbohydrate mouth rinse maintains muscle electromyographic activity and increases time to exhaustion during moderate but not high-intensity cycling exercise. Nutrients. 2016;8:49.CrossRefPubMedPubMedCentral Bastos-Silva VJ, Melo Ade A, Lima-Silva AE, Moura FA, Bertuzzi R, de Araujo GG. Carbohydrate mouth rinse maintains muscle electromyographic activity and increases time to exhaustion during moderate but not high-intensity cycling exercise. Nutrients. 2016;8:49.CrossRefPubMedPubMedCentral
13.
go back to reference Rollo IAN, Williams C, Nevill M. Influence of ingesting versus mouth rinsing a carbohydrate solution during a 1-h run. Med Sci Sport Exerc. 2011;43:468–75.CrossRef Rollo IAN, Williams C, Nevill M. Influence of ingesting versus mouth rinsing a carbohydrate solution during a 1-h run. Med Sci Sport Exerc. 2011;43:468–75.CrossRef
14.
go back to reference Lane SC, Bird SR, Burke LM, Hawley JA. Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Appl Physiol Nutr Metab. 2013;38:134–9.CrossRefPubMed Lane SC, Bird SR, Burke LM, Hawley JA. Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Appl Physiol Nutr Metab. 2013;38:134–9.CrossRefPubMed
15.
go back to reference Pottier A, Bouckaert J, Gilis W, Roels T, Derave W. Mouth rinse but not ingestion of a carbohydrate solution improves 1-h cycle time trial performance. Scand J Med Sci Sport. 2010;20:105–11.CrossRef Pottier A, Bouckaert J, Gilis W, Roels T, Derave W. Mouth rinse but not ingestion of a carbohydrate solution improves 1-h cycle time trial performance. Scand J Med Sci Sport. 2010;20:105–11.CrossRef
16.
go back to reference Beelen M, Berghuis J, Bonaparte B, Ballak SB, Jeukendrup AE, van Loon LJC. Carbohydrate mouth rinsing in the fed state: lack of enhancement of time-trial performance. Int J Sport Nutr Exerc Metab. 2009;19:400–9.CrossRefPubMed Beelen M, Berghuis J, Bonaparte B, Ballak SB, Jeukendrup AE, van Loon LJC. Carbohydrate mouth rinsing in the fed state: lack of enhancement of time-trial performance. Int J Sport Nutr Exerc Metab. 2009;19:400–9.CrossRefPubMed
17.
go back to reference Trommelen J, Beelen M, Mullers M, Gibala MJ, van Loon LJC, Cermak NM. A sucrose mouth rinse does not improve 1-hr cycle time trial performance when performed in the fasted or fed state. Int J Sport Nutr Exerc Metab. 2015;25:576–83.CrossRefPubMed Trommelen J, Beelen M, Mullers M, Gibala MJ, van Loon LJC, Cermak NM. A sucrose mouth rinse does not improve 1-hr cycle time trial performance when performed in the fasted or fed state. Int J Sport Nutr Exerc Metab. 2015;25:576–83.CrossRefPubMed
18.
go back to reference Kulaksız TN, Koşar ŞN, Bulut S, Güzel Y, Willems MET, Hazir T, et al. Mouth rinsing with maltodextrin solutions fails to improve time trial endurance cycling performance in recreational athletes. Nutrients. 2016;8:2–15.CrossRef Kulaksız TN, Koşar ŞN, Bulut S, Güzel Y, Willems MET, Hazir T, et al. Mouth rinsing with maltodextrin solutions fails to improve time trial endurance cycling performance in recreational athletes. Nutrients. 2016;8:2–15.CrossRef
19.
go back to reference Pires FO, Brietzke C, Pinheiro FA, Veras K, de Mattos ECT, Rodacki ALF, et al. Carbohydrate mouth rinse fails to improve four-kilometer cycling time trial performance. Nutrients. 2018;10:342.CrossRef Pires FO, Brietzke C, Pinheiro FA, Veras K, de Mattos ECT, Rodacki ALF, et al. Carbohydrate mouth rinse fails to improve four-kilometer cycling time trial performance. Nutrients. 2018;10:342.CrossRef
20.
go back to reference Fraga C, Velasques B, Koch AJ, Machado M, Paulucio D, Ribeiro P, et al. Carbohydrate mouth rinse enhances time to exhaustion during treadmill exercise. Clin Physiol Funct Imaging. 2017;37:17–22.CrossRefPubMed Fraga C, Velasques B, Koch AJ, Machado M, Paulucio D, Ribeiro P, et al. Carbohydrate mouth rinse enhances time to exhaustion during treadmill exercise. Clin Physiol Funct Imaging. 2017;37:17–22.CrossRefPubMed
22.
go back to reference Ispoglou T, OʼKelly D, Angelopoulou A, Bargh M, OʼHara JP, Duckworth LC. Mouth rinsing with carbohydrate solutions at the postprandial state fail to improve performance during simulated cycling time trials. J Strength Cond Res. 2015;29:2316–25.CrossRefPubMed Ispoglou T, OʼKelly D, Angelopoulou A, Bargh M, OʼHara JP, Duckworth LC. Mouth rinsing with carbohydrate solutions at the postprandial state fail to improve performance during simulated cycling time trials. J Strength Cond Res. 2015;29:2316–25.CrossRefPubMed
23.
go back to reference Rollo I, Williams C. Effect of mouth-rinsing carbohydrate solutions on endurance performance. Sports Med. 2011;41:449–61.CrossRefPubMed Rollo I, Williams C. Effect of mouth-rinsing carbohydrate solutions on endurance performance. Sports Med. 2011;41:449–61.CrossRefPubMed
24.
go back to reference Jeukendrup AE. Oral carbohydrate rinse: placebo or beneficial? Curr Sports Med Rep. 2013;12:222–7.CrossRefPubMed Jeukendrup AE. Oral carbohydrate rinse: placebo or beneficial? Curr Sports Med Rep. 2013;12:222–7.CrossRefPubMed
25.
go back to reference Jeukendrup AE, Chambers ES. Oral carbohydrate sensing and exercise performance. Curr Opin Clin Nutr Metab Care. 2010;13:447–51.CrossRefPubMed Jeukendrup AE, Chambers ES. Oral carbohydrate sensing and exercise performance. Curr Opin Clin Nutr Metab Care. 2010;13:447–51.CrossRefPubMed
26.
go back to reference Jeukendrup AE, Rollo I, Carter JM. Carbohydrate mouth rinse: performance effects and mechanisms. Sport Sci Exch. 2013;26:1–8. Jeukendrup AE, Rollo I, Carter JM. Carbohydrate mouth rinse: performance effects and mechanisms. Sport Sci Exch. 2013;26:1–8.
27.
go back to reference de Ataide e Silva TA, Di Calvalcanti Alves de Souza ME, de Amorim JF, Stathis CG, Leandro CGG, Lima-Silva AE. Can carbohydrate mouth rinse improve performance during exercise? A systematic review. Nutrients. 2013;6:1–10.CrossRefPubMed de Ataide e Silva TA, Di Calvalcanti Alves de Souza ME, de Amorim JF, Stathis CG, Leandro CGG, Lima-Silva AE. Can carbohydrate mouth rinse improve performance during exercise? A systematic review. Nutrients. 2013;6:1–10.CrossRefPubMed
28.
go back to reference Peart DJ. Quantifying the effect of carbohydrate mouth rinsing on exercise performance. J Strength Cond Res. 2017;31:1737–43.CrossRefPubMed Peart DJ. Quantifying the effect of carbohydrate mouth rinsing on exercise performance. J Strength Cond Res. 2017;31:1737–43.CrossRefPubMed
29.
go back to reference Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.CrossRefPubMedPubMedCentral Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.CrossRefPubMedPubMedCentral
30.
go back to reference Stewart B, Outram S, Smith ACT. Doing supplements to improve performance in club cycling: a life-course analysis. Scand J Med Sci Sports. 2013;23:e361–72.CrossRefPubMed Stewart B, Outram S, Smith ACT. Doing supplements to improve performance in club cycling: a life-course analysis. Scand J Med Sci Sports. 2013;23:e361–72.CrossRefPubMed
31.
go back to reference Pires FO, Dos Anjos CA, Covolan RJ, Pinheiro FA, St Clair Gibson A, Noakes TD, et al. Cerebral regulation in different maximal aerobic exercise modes. Front Physiol. 2016;7:253.CrossRefPubMedPubMedCentral Pires FO, Dos Anjos CA, Covolan RJ, Pinheiro FA, St Clair Gibson A, Noakes TD, et al. Cerebral regulation in different maximal aerobic exercise modes. Front Physiol. 2016;7:253.CrossRefPubMedPubMedCentral
32.
go back to reference Silva RAS, Silva-Júnior FL, Pinheiro FA, Souza PFM, Boullosa DA, Pires FO. Acute prior heavy strength exercise bouts improve the 20-km cycling time trial performance. J Strength Cond Res. 2014;28:2513–20.CrossRefPubMed Silva RAS, Silva-Júnior FL, Pinheiro FA, Souza PFM, Boullosa DA, Pires FO. Acute prior heavy strength exercise bouts improve the 20-km cycling time trial performance. J Strength Cond Res. 2014;28:2513–20.CrossRefPubMed
33.
go back to reference Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009;151:W65–94.CrossRefPubMed Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009;151:W65–94.CrossRefPubMed
36.
go back to reference Murray KO, Paris HL, Fly AD, Chapman RF, Mickleborough TD. Carbohydrate mouth rinse improves cycling time-trial performance without altering plasma insulin concentration. J Sports Sci Med. 2018;17:145–52.PubMedPubMedCentral Murray KO, Paris HL, Fly AD, Chapman RF, Mickleborough TD. Carbohydrate mouth rinse improves cycling time-trial performance without altering plasma insulin concentration. J Sports Sci Med. 2018;17:145–52.PubMedPubMedCentral
37.
go back to reference Ferreira AMJ, Farias-Junior LF, Mota TAA, Elsangedy HM, Marcadenti A, Lemos TMAM, et al. Carbohydrate mouth rinse and hydration strategies on cycling performance in 30 km time trial: a randomized, crossover, controlled trial. J Sport Sci Med. 2018;17:181–7. Ferreira AMJ, Farias-Junior LF, Mota TAA, Elsangedy HM, Marcadenti A, Lemos TMAM, et al. Carbohydrate mouth rinse and hydration strategies on cycling performance in 30 km time trial: a randomized, crossover, controlled trial. J Sport Sci Med. 2018;17:181–7.
38.
go back to reference Pöchmüller M, Schwingshackl L, Colombani PC, Hoffmann G. A systematic review and meta-analysis of carbohydrate benefits associated with randomized controlled competition-based performance trials. J Int Soc Sports Nutr. 2016;13:27.CrossRefPubMedPubMedCentral Pöchmüller M, Schwingshackl L, Colombani PC, Hoffmann G. A systematic review and meta-analysis of carbohydrate benefits associated with randomized controlled competition-based performance trials. J Int Soc Sports Nutr. 2016;13:27.CrossRefPubMedPubMedCentral
39.
go back to reference Gant N, Stinear CM, Byblow WD. Carbohydrate in the mouth immediately facilitates motor output. Brain Res. 2010;1350:151–8.CrossRefPubMed Gant N, Stinear CM, Byblow WD. Carbohydrate in the mouth immediately facilitates motor output. Brain Res. 2010;1350:151–8.CrossRefPubMed
Metadata
Title
Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-Analysis
Authors
Cayque Brietzke
Paulo Estevão Franco-Alvarenga
Hélio José Coelho-Júnior
Rodrigo Silveira
Ricardo Yukio Asano
Flávio Oliveira Pires
Publication date
01-01-2019
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 1/2019
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-018-1029-7

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