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Sports Medicine
Published in: Sports Medicine 1/2017

01-01-2017 | Systematic Review

Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis

Authors: Charlotte Lanhers, Bruno Pereira, Geraldine Naughton, Marion Trousselard, François-Xavier Lesage, Frédéric Dutheil

Published in: Sports Medicine | Issue 1/2017

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Abstract

Background

Creatine is the most widely used supplementation to increase performance in strength; however, the most recent meta-analysis focused specifically on supplementation responses in muscles of the lower limbs without regard to upper limbs.

Objective

We aimed to systematically review the effect of creatine supplementation on upper limb strength performance.

Methods

We conducted a systematic review and meta-analyses of all randomized controlled trials comparing creatine supplementation with a placebo, with strength performance measured in exercises shorter than 3 min in duration. The search strategy used the keywords ‘creatine’, ‘supplementation’, and ‘performance’. Independent variables were age, sex and level of physical activity at baseline, while dependent variables were creatine loading, total dose, duration, time interval between baseline (T0) and the end of the supplementation (T1), and any training during supplementation. We conducted three meta-analyses: at T0 and T1, and on changes between T0 and T1. Each meta-analysis was stratified within upper limb muscle groups.

Results

We included 53 studies (563 individuals in the creatine supplementation group and 575 controls). Results did not differ at T0, while, at T1, the effect size (ES) for bench press and chest press were 0.265 (95 % CI 0.132–0.398; p < 0.001) and 0.677 (95 % CI 0.149–1.206; p = 0.012), respectively. Overall, pectoral ES was 0.289 (95 % CI 0.160–0.419; p = 0.000), and global upper limb ES was 0.317 (95 % CI 0.185–0.449; p < 0.001). Meta-analysis of changes between T0 and T1 gave similar results. The meta-regression showed no link with characteristics of population or supplementation, demonstrating the efficacy of creatine independently of all listed conditions.

Conclusion

Creatine supplementation is effective in upper limb strength performance for exercise with a duration of less than 3  min, independent of population characteristics, training protocols, and supplementary doses or duration.
Appendix
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Literature
1.
Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000;80:1107–213.PubMed
2.
Tscholl P, Alonso JM, Dolle G, et al. The use of drugs and nutritional supplements in top-level track and field athletes. Am J Sports Med. 2010;38:133–40.CrossRefPubMed
3.
Lanhers C, Pereira B, Naughton G, et al. Creatine supplementation and lower limb strength performance: asystematic review and meta-analyses. Sports Med. 2015;45:1285–94.CrossRefPubMed
4.
Gastin PB. Energy system interaction and relative contribution during maximal exercise. Sports Med. 2001;31:725–41.CrossRefPubMed
5.
Pollo A, Carlino E, Benedetti F. Placebo mechanisms across different conditions: from the clinical setting to physical performance. Philos Trans R Soc Lond B Biol Sci. 2011;366:1790–8.CrossRefPubMedPubMedCentral
6.
Moher D, Hopewell S, Schulz KF, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c869.CrossRefPubMedPubMedCentral
7.
8.
Cohen J. Statistical power analysis for the behavioral sciences. Mahwah: Lawrence Erlbaum; 1988.
9.
Aguiar AF, Januario RSB, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013;113:987–96.CrossRefPubMed
10.
Bemben MG, Witten MS, Carter JM, et al. The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men. J Nutr Health Aging. 2010;14:155–9.CrossRefPubMed
11.
Candow DG, Little JP, Chilibeck PD, et al. Low-dose creatine combined with protein during resistance training in older men. Med Sci Sports Exerc. 2008;40:1645–52.CrossRefPubMed
12.
Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA. 1996;276:637–9.CrossRefPubMed
13.
Azizi M. The effect of a short-term creatine supplementation on some of the anaerobic performance and sprint swimming records of female competitive swimmers. Procedia Soc Behav Sci. 2011;15:1626–9.CrossRef
14.
Brenner M, Rankin JW, Sebolt D. The effect of creatine supplementation during resistance training in women. J Strength Cond Res. 2000;14:207–13.
15.
Ferguson TB, Syrotuik DG. Effects of creatine monohydrate supplementation on body composition and strength indices in experienced resistance trained women. J Strength Cond Res. 2006;20:939–46.PubMed
16.
Gualano B, Macedo AR, Alves CR, et al. Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. Exp Gerontol. 2014;53:7–15.CrossRefPubMed
17.
Hamilton KL, Meyers MC, Skelly WA, et al. Oral creatine supplementation and upper extremity anaerobic response in females. Int J Sport Nutr Exerc Metab. 2000;10:277–89.CrossRefPubMed
18.
Larson-Meyer DE, Hunter GR, Trowbridge CA, et al. The effect of creatine supplementation on muscle strength and body composition during off-season training in female soccer players. J Strength Cond Res. 2000;14:434–42.
19.
Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1985;83:2055–63.
20.
Burke DG, Silver S, Holt LE, et al. The effect of continuous low dose creatine supplementation on force, power, and total work. Int J Sport Nutr Exerc Metab. 2000;10:235–44.CrossRefPubMed
21.
Burke DG, Chilibeck PD, Parise G, et al. Effect of creatine and weight training on muscle creatine and performance in vegetarians. Med Sci Sports Exerc. 2003;35:1946–55.CrossRefPubMed
22.
Stout JR, Graves BS, Cramer JT, et al. Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64–6 years). J Nutr Health Aging. 2007;11:459–64.PubMed
23.
Camic CL, Housh TJ, Zuniga JM, et al. The effects of polyethylene glycosylated creatine supplementation on anaerobic performance measures and body composition. J Strength Cond Res. 2014;28:825–33.CrossRefPubMed
24.
Peeters BM, Lantz CD, Mayhew JL. Effect of oral creatine monohydrate and creatine phosphate supplementation on maximal strength indices, dody composition, and blood pressure. J Strength Cond Res. 1999;13:3–9.
25.
Pluim BM, Ferrauti A, Broekhof F, et al. The effects of creatine supplementation on selected factors of tennis specific training. Br J Sports Med. 2006;40:507–12.CrossRefPubMedPubMedCentral
26.
Volek JS, Ratamess NA, Rubin MR, et al. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur J Appl Physiol. 2004;91:628–37.CrossRefPubMed
27.
Noonan D, Berg K, Latin RW, et al. Effects of varying dosages of oral creatine relative to fat free body mass on strength and body composition. J Strength Cond Res. 1998;12:104–8.
28.
Izquierdo M, Ibanez J, Gonzalez-Badillo JJ, et al. Effects of creatine supplementation on muscle power, endurance, and sprint performance. Med Sci Sports Exerc. 2002;34:332–43.CrossRefPubMed
29.
Law YL, Ong WS, GillianYap TL, et al. Effects of two and five days of creatine loading on muscular strength and anaerobic power in trained athletes. J Strength Cond Res. 2009;23:906–14.CrossRefPubMed
30.
Syrotuik DG, Bell GJ, Burnham R, et al. Absolute and relative strength performance following creatine monohydrate supplementation combined with periodized resistance training. J Strength Cond Res. 2000;14:182–90.
31.
Warber JP, Tharion WJ, Patton JF, et al. The effect of creatine monohydrate supplementation on obstacle course and multiple bench press performance. J Strength Cond Res. 2002;16:500–8.PubMed
32.
Bermon S, Venembre P, Sachet C, et al. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand. 1998;164:147–55.CrossRefPubMed
33.
del Favero S, Roschel H, Artioli G, et al. Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance. Amino Acids. 2012;42:2299–305.CrossRefPubMed
34.
Earnest CP, Snell PG, Rodriguez R, et al. The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand. 1995;153:207–9.CrossRefPubMed
35.
Gotshalk LA, Volek JS, Staron RS, et al. Creatine supplementation improves muscular performance in older men. Med Sci Sports Exerc. 2002;34:537–43.CrossRefPubMed
36.
Stout J, Eckerson J, Noonan D, et al. Effects of 8 weeks of creatine supplementation on exercise performance and fat-free weight in football players during training. Nutr Res. 1999;19:217–25.CrossRef
37.
Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol. 1999;80:139–44.CrossRefPubMed
38.
Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults-a meta-analysis. Med Sci Sports Exerc. 2014;46:1194–203.CrossRefPubMed
39.
Candow DG, Chilibeck PD, Forbes SC. Creatine supplementation and aging musculoskeletal health. Endocrine. 2014;45:354–61.CrossRefPubMed
40.
Villanueva MG, He J, Schroeder ET. Periodized resistance training with and without supplementation improve body composition and performance in older men. Eur J Appl Physiol. 2014;114:891–905.CrossRefPubMed
41.
da Silveira CL, de Souza TS, Batista GR, et al. Is long term creatine and glutamine supplementation effective in enhancing physical performance of military police officers? J Hum Kinet. 2014;43:131–8.PubMedPubMedCentral
42.
de Salles Painelli V, Alves VT, Ugrinowitsch C, et al. Creatine supplementation prevents acute strength loss induced by concurrent exercise. Eur J Appl Physiol. 2014;114:1749–55.CrossRef
43.
Brose A, Parise G, Tarnopolsky MA. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci. 2003;58:11–9.CrossRefPubMed
44.
Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003;17:822–31.PubMed
45.
Becque MD, Lochmann JD, Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc. 2000;32:654–8.CrossRefPubMed
46.
Chilibeck PD, Magnus C, Anderson M. Effect of in-season creatine supplementation on body composition and performance in rugby union football players. Appl Physiol Nutr Metab. 2007;32:1052–7.CrossRefPubMed
47.
Burke LM, Pyne DB, Telford RD. Effect of oral creatine supplementation on single-effort sprint performance in elite swimmers. Int J Sport Nutr. 1996;6:222–33.CrossRefPubMed
48.
Pearson DR, Russel DGHW, Harris T. Long-term effects of creatine monohydrate on strength and power. J Strength Cond Res. 1999;13:187–92.
49.
Volek JS, Duncan ND, Mazzetti SA, et al. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc. 1999;31:1147–56.CrossRefPubMed
50.
Volek JS, Kraemer WJ, Bush JA, et al. Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc. 1997;97:765–70.CrossRefPubMed
51.
Chrusch MJ, Chilibeck PD, Chad KE, et al. Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc. 2001;33:2111–7.CrossRefPubMed
52.
Kelly V, Jenkins DG. Effect of oral creatine supplementation on near-maximal strength and repeated sets of high-intensity bench press exercise. J Strength Cond Res. 1998;12:109–15.
53.
Selsby JT, DiSilvestro RA, Devor ST. Mg2+-creatine chelate and a low-dose creatine supplementation regimen improve exercise performance. J Strength Cond Res. 2004;18:311–5.PubMed
54.
Herda TJ, Beck TW, Ryan ED, et al. Effects of creatine monohydrate and polyethylene glycosylated creatine supplementation on muscular strength, endurance, and power output. J Strength Cond Res. 2009;23:818–26.CrossRefPubMed
55.
Stone MH, Sanborn K, Smith LL, et al. Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr. 1999;9:146–65.CrossRefPubMed
56.
Zuniga JM, Housh TJ, Camic CL, et al. The effects of creatine monohydrate loading on anaerobic performance and one-repetition maximum strength. J Strength Cond Res. 2012;26:1651–6.CrossRefPubMed
57.
LeLorier J, Gregoire G, Benhaddad A, et al. Discrepancies between meta-analyses and subsequent large randomized, controlled trials. N Engl J Med. 1997;337:536–42.CrossRefPubMed
58.
Bogdanis GC, Nevill ME, Lakomy HKA, et al. The effects of oral creatine supplementation on power output during repeated treadmill sprinting. J Sports Sci. 1996;14:65–6.
59.
Urbanski RL, Vincent WJ, Yaspelkis BB. Creatine supplementation differentially affects maximal isometric strength and time to fatigue in large and small muscle groups. Int J Sport Nutr. 1999;9:136–45.CrossRefPubMed
60.
Dempsey RL, Mazzone MF, Meurer LN. Does oral creatine supplementation improve strength? A meta-analysis. J Fam Pract. 2002;51:945–51.PubMed
61.
Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab. 2003;13:198–226.CrossRefPubMed
62.
Nissen SL, Sharp RL. Effect of dietary supplements on lean mass and strength gains with resistance exercise: a meta-analysis. J Appl Physiol. 1985;2003(94):651–9.
Metadata
Title
Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis
Authors
Charlotte Lanhers
Bruno Pereira
Geraldine Naughton
Marion Trousselard
François-Xavier Lesage
Frédéric Dutheil
Publication date
01-01-2017
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 1/2017
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-016-0571-4

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