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Sports Medicine
Published in: Sports Medicine 2/2015

01-02-2015 | Review Article

Vitamin D: Recent Advances and Implications for Athletes

Authors: Joshua J. Todd, L. Kirsty Pourshahidi, Emeir M. McSorley, Sharon M. Madigan, Pamela J. Magee

Published in: Sports Medicine | Issue 2/2015

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Abstract

Athletes may be predisposed to low vitamin D concentrations, with studies reporting a high prevalence of athletes with a vitamin D concentration below 50 nmol/L across a range of sports and geographical locations, particularly over the winter months. It is well documented that vitamin D is important for osseous health by enhancing calcium absorption at the small intestine; however, emerging research suggests that vitamin D may also benefit a plethora of extra-skeletal target tissues and systems. There is strong evidence that vitamin D is capable of regulating both innate and adaptive immune processes via binding of active vitamin D to its complementary receptor. Supplementation with vitamin D may also enhance skeletal muscle function through morphological adaptations and enhanced calcium availability during cross-bridge cycling; however, an exact mechanism of action is yet to be elucidated. Such findings have prompted research into the importance of maintaining vitamin D concentrations over wintertime and the possible physiological and immunological benefits of vitamin D supplementation in athletes. The following review critically evaluates existing literature and presents novel perspectives on how vitamin D may enhance athletic performance.
Literature
1.
Webb AR. Who, what, where and when-influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol. 2006;92(1):17–25.PubMed
2.
Ovesen L, Andersen R, Jakobsen J. Geographical differences in vitamin D status, with particular reference to European countries. Proc Nutr Soc. 2003;62(4):813–21.PubMed
3.
Calvo MS, Whiting SJ, Barton CN. Vitamin D fortification in the United States and Canada: current status and data needs. Am J Clin Nutr. 2004;80(6 Suppl):1710S–6S.PubMed
4.
Heaney RP, Armas LA, Shary JR, et al. 25-hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr. 2008;87(6):1738–42.PubMed
5.
Gallagher JC, Sai AJ. Vitamin D insufficiency, deficiency, and bone health. J Clin Endocrinol Metab. 2010;95(6):2630–3.PubMedCentralPubMed
6.
Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys. 2012;523(1):123–33.PubMed
7.
Lips P. Vitamin D physiology. Prog Biophys Mol Biol. 2006;92(1):4–8.PubMed
8.
9.
European Food Safety Authority (EFSA). Scientific opinion on the tolerable upper intake level of vitamin D. EFSA J. 2012;10(7):2813.
10.
Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69(5):842–56.PubMed
11.
Ozkan B, Hatun S, Bereket A. Vitamin D intoxication. Turk J Pediatr. 2012;54(2):93–8.PubMed
12.
Ahmed MS, Shoker A. Vitamin D metabolites; protective versus toxic properties: molecular and cellular perspectives. Nephrol Rev. 2010;2(1):19–26.
13.
Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 2008;88(2):582S–6S.PubMed
14.
Prentice A, Goldberg GR, Schoenmakers I. Vitamin D across the lifecycle: physiology and biomarkers. Am J Clin Nutr. 2008;88(2):500S–6S.PubMed
15.
Institute of Medicine (IOM). Dietary reference intakes for calcium and vitamin D. Washington DC: The National Academies Press; 2011.
16.
Shoenfeld N, Amital H, Shoenfeld Y. The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Nat Clin Pract Rheumatol. 2009;5(2):99–105.PubMed
17.
Mithal A, Wahl DA, Bonjour J, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20(11):1807–20.PubMed
18.
Gannage-Yared MH, Maalouf G, Khalife S, et al. Prevalence and predictors of vitamin D inadequacy amongst Lebanese osteoporotic women. Br J Nutr. 2009;101(4):487–91.PubMed
19.
Diamond TH, Levy S, Smith A, et al. High bone turnover in Muslim women with vitamin D deficiency. Med J Aust. 2002;177(3):139–41.PubMed
20.
Wortsman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690–3.PubMed
21.
Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80(6S):1678S–8S.
22.
23.
Matsuoka LY, Ide L, Wortsman J, et al. Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab. 1987;64(6):1165–8.PubMed
24.
Norval M, Wulf HC. Does chronic sunscreen use reduce vitamin D production to insufficient levels? Br J Dermatol. 2009;161(4):732–6.PubMed
25.
Burnett ME, Wang SQ. Current sunscreen controversies: a critical review. Photodermatol Photoimmunol Photomed. 2011;27(2):58–67.PubMed
26.
Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. 1988;67(2):373–8.PubMed
27.
Huotari A, Herzig KH. Vitamin D and living in northern latitudes—an endemic risk area for vitamin D deficiency. Int J Circumpolar Health. 2008;67(2–3):164–78.PubMed
28.
MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536–8.PubMedCentralPubMed
29.
Vieth R, Ladak Y, Walfish PG. Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab. 2003;88(1):185–91.PubMed
30.
Engelman CD. Vitamin D recommendations: the saga continues. J Clin Endocrinol Metab. 2011;96(10):3065–6.PubMed
31.
Pramyothin P, Holick MF. Vitamin D supplementation: guidelines and evidence for subclinical deficiency. Curr Opin Gastroenterol. 2012;28(2):139–50.PubMed
32.
Pearce SH, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ. 2010;11(340):b5664.
33.
Heaney RP. Assessing vitamin D status. Curr Opin Clin Nutr Metab Care. 2011;14(5):440–4.PubMed
34.
Close GL, Fraser WD. Vitamin D supplementation for athletes: too much of a good thing? Sport Exercise Scientist. 2012;33:24–5.
35.
Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53–8.PubMedCentralPubMed
36.
Hill KM, Jonnalagadda SS, Albertson AM, et al. Top food sources contributing to vitamin D intake and the association of ready-to-eat cereal and breakfast consumption habits to vitamin D intake in Canadians and United States Americans. J Food Sci. 2012;77(8):170–5.
37.
38.
Lovell G. Vitamin D status of females in an elite gymnastics program. Clin J Sport Med. 2008;18(2):159–61.PubMed
39.
Close GL, Russell J, Cobley JN, et al. Assessment of vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function. J Sports Sci. 2013;31(4):344–53.PubMed
40.
Kopec A, Solarz K, Majda F, et al. An evaluation of the levels of vitamin D and bone turnover markers after the summer and winter periods in Polish professional soccer players. J Hum Kinet. 2013;8(38):135–40.
41.
Lanteri P, Lombardi G, Colombini A, et al. Vitamin D in exercise: physiologic and analytical concerns. Clin Chim Acta. 2013;415:45–53.PubMed
42.
Constantini NW, Arieli R, Chodick G, et al. High prevalence of vitamin D insufficiency in athletes and dancers. Clin J Sport Med. 2010;20(5):368–71.PubMed
43.
Hamilton B, Grantham J, Racinais S, et al. Vitamin D deficiency is endemic in Middle Eastern sportsmen. Public Health Nutr. 2010;13(10):1528–34.PubMed
44.
Naeem Z. Vitamin D deficiency—an ignored epidemic. Int J Health Sci. 2010;4(1):V-VI.
45.
Lai JK, Lucas RM, Banks E, et al. Variability in vitamin D assays impairs clinical assessment of vitamin D status. Intern Med J. 2012;42(41):43–50.PubMed
46.
Shah I, James R, Barker J, et al. Misleading measures in vitamin D analysis: a novel LC-MS/MS assay to account for epimers and isobars. Nutr J. 2011;10:46.
47.
Wallace AM, Gibson S, de la Hunty A, et al. Measurement of 25-hydroxyvitamin D in the clinical laboratory: current procedures, performance characteristics and limitations. Steroids. 2010;75(7):477–88.PubMed
48.
Lai JK, Lucas RM, Clements MS, et al. Assessing vitamin D status: pitfalls for the unwary. Mol Nutr Food Res. 2010;54(8):1062–71.PubMed
49.
Snellman G, Melhus H, Gedeborg R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One. 2010;5(7):e11555.PubMedCentralPubMed
50.
Bolek-Berquist J, Elliott ME, Gangnon RE, et al. Use of a questionnaire to assess vitamin D status in young adults. Public Health Nutr. 2009;12(2):236–43.PubMedCentralPubMed
51.
Carter GD. 25-hydroxyvitamin D assays: the quest for accuracy. Clin Chem. 2009;55(7):1300–2.PubMed
52.
Taylor C, Lamparello B, Kruczek K, et al. Validation of a food frequency questionnaire for determining calcium and vitamin D intake by adolescent girls with anorexia nervosa. J Am Diet Assoc. 2009;109(3):479–85.PubMedCentralPubMed
53.
Hebden L, Kostan E, O’Leary F, et al. Validity and reproducibility of a food frequency questionnaire as a measure of recent dietary intake in young adults. PloS one. 2013;e75156.
54.
Chen TC, Shao Q, Heath H, et al. An update on the vitamin D content of fortified milk from the United States and Canada. N Engl J Med. 1993;329(20):1507.PubMed
55.
Chen TC, Chimeh F, Lu Z, et al. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys. 2007;460(2):213–7.PubMedCentralPubMed
56.
Cashman KD, Hill TR, Lucey AJ, et al. Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr. 2008;88(6):1535–42.PubMed
57.
Kulie T, Groff A, Redmer J, et al. Vitamin D: an evidence-based review. J Am Board Fam Med. 2009;22(6):698–706.PubMed
58.
Christodoulou S, Goula T, Ververidis A, et al. Vitamin D and bone disease. BioMed Res Int. 2013; 396541.
59.
Wood RJ, Tchack L, Taparia S. 1,25-dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the caco-2 human intestinal cell line. BMC Physiol. 2001;1:11.PubMedCentralPubMed
60.
Wasserman RH. Vitamin D and the dual processes of intestinal calcium absorption. J Nutr. 2004;134(11):3137–9.PubMed
61.
Christakos S. Recent advances in our understanding of 1,25-dihydroxyvitamin D(3) regulation of intestinal calcium absorption. Arch Biochem Biophys. 2012;523(1):73–6.PubMedCentralPubMed
62.
Christakos S, Dhawan P, Porta A, et al. Vitamin D and intestinal calcium absorption. Mol Cell Endocrinol. 2011;347(1–2):25–9.PubMedCentralPubMed
63.
Wacker M, Holick MF. Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5(1):111–48.PubMedCentralPubMed
64.
Pasco JA, Henry MJ, Kotowicz MA, et al. Seasonal periodicity of serum vitamin D and parathyroid hormone, bone resorption, and fractures: the Geelong osteoporosis study. J Bone Miner Res. 2004;19(5):752–8.PubMed
65.
Villareal DT, Civitelli R, Chines A, et al. Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass. J Clin Endocrinol Metab. 1991;72(3):628–34.PubMed
66.
Holick MF. The role of vitamin D for bone health and fracture prevention. Curr Osteoporos Rep. 2006;4(3):96–102.PubMed
67.
Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122(5):1142–52.PubMed
68.
Shaw NJ, Mughal MZ. Vitamin D and child health part 1 (skeletal aspects). Arch Dis Child. 2013;98(5):363–7.PubMed
69.
Kremer R, Campbell PP, Reinhardt T, et al. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009;94(1):67–73.PubMedCentralPubMed
70.
Pekkinen M, Viljakainen H, Saarnio E, et al. Vitamin D is a major determinant of bone mineral density at school age. PLoS One. 2012;e40090.
71.
Jones BH, Thacker SB, Gilchrist J, et al. Prevention of lower extremity stress fractures in athletes and soldiers: a systematic review. Epidemiol Rev. 2002;24(2):228–47.PubMed
72.
Iwamoto J, Sato Y, Takeda T, et al. Analysis of stress fractures in athletes based on our clinical experience. World J Orthop. 2011;2(1):7–12.PubMedCentralPubMed
73.
Bennell KL, Malcolm SA, Thomas SA, et al. Risk factors for stress fractures in track and field athletes. A twelve-month prospective study. Am J Sports Med. 1996;24(6):810–8.PubMed
74.
Haydari M, Rahnama N, Khayambashi K, et al. Association between bone mass and injuries in professional jumpers. Br J Sports Med. 2010;44:i5.
75.
Pope CG, Pope HG, Menard W, et al. Clinical features of muscle dysmorphia among males with body dysmorphic disorder. Body Image. 2005;2(4):395–400.PubMedCentralPubMed
76.
Baum A. Eating disorders in the male athlete. Sports Med. 2006;36(1):1–6.PubMed
77.
Chen YT, Tenforde AS, Fredericson M. Update on stress fractures in female athletes: epidemiology, treatment, and prevention. Curr Rev Musculoskelet Med. 2013;6(2):173–81.PubMedCentralPubMed
78.
Marquez S, Molinero O. Energy availability, menstrual dysfunction and bone health in sports; an overview of the female athlete triad. Nutr Hosp. 2013;28(4):1010–7.PubMed
79.
Nieves JW, Melsop K, Curtis M, et al. Nutritional factors that influence change in bone density and stress fracture risk among young female cross-country runners. PM R. 2010;2(8):740–50.PubMed
80.
Lewis RM, Redzic M, Thomas DT. The effects of season-long vitamin D supplementation on collegiate swimmers and divers. Int J Sport Nutr Exerc Metab. 2013;23(5):431–40.
81.
Bellows M, Tanguay J, Crouse SF, et al. In: Vitamin D deficiency in TAMU female basketball players and supplement effectiveness. Int J Exerc Sci: Conference proceedings; 2013.
82.
Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003;326(7387):469.PubMedCentralPubMed
83.
Winzenberg T, Powell S, Shaw KA, et al. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis. BMJ. 2011;342:c7254.PubMedCentralPubMed
84.
85.
Looker AC, Mussolino ME. Serum 25-hydroxyvitamin D and hip fracture risk in older U.S. white adults. J Bone Miner Res. 2008;23(1):143–50.PubMed
86.
87.
Lappe J, Cullen D, Haynatzki G, et al. Calcium and vitamin D supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res. 2008;23(5):741–9.PubMed
88.
von Domarus C, Brown J, Barvencik F, et al. How much vitamin D do we need for skeletal health? Clin Orthop Relat Res. 2011;469(11):3127–33.
89.
90.
Girgis CM, Clifton-Bligh RJ, Hamrick MW, et al. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2013;34(1):33–83.PubMed
91.
Pfeifer M, Begerow B, Minne HW. Vitamin D and muscle function. Osteoporos Int. 2002;13(3):187–94.PubMed
92.
Willis KS, Peterson NJ, Larson-Meyer DE. Should we be concerned about the vitamin D status of athletes? Int J Sport Nutr Exerc Metab. 2008;18(2):204–24.PubMed
93.
Rejnmark L. Effects of vitamin D on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis. 2011;2(1):25–37.PubMedCentralPubMed
94.
Girgis CM, Clifton-Bligh RJ, Turner N, et al. Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clin Endocrinol (Oxf). 2013;80(2):169–81.
95.
Ward KA, Das G, Berry JL, et al. Vitamin D status and muscle function in post-menarchal adolescent girls. J Clin Endocrinol Metab. 2009;94(2):559–63.PubMed
96.
Marantes I, Achenbach SJ, Atkinson EJ, et al. Is vitamin D a determinant of muscle mass and strength? J Bone Miner Res. 2011;26(12):2860–71.PubMedCentralPubMed
97.
Barker T, Henriksen VT, Martins TB, et al. Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients. 2013;5(4):1253–75.PubMedCentralPubMed
98.
Barker T, Martins TB, Hill HR, et al. Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults. Eur J Appl Physiol. 2013;113(6):1523–34.PubMed
99.
Close GL, Leckey J, Patterson M, et al. The effects of vitamin D(3) supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose-response study. Br J Sports Med. 2013;47(11):692–6.PubMed
100.
Barker T, Martins TB, Hill HR, et al. Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans. Cytokine. 2014;65(2):134–7.PubMed
101.
Hamilton B, Whiteley R, Farooq A, et al. Vitamin D concentration in 342 professional football players and association with lower limb isokinetic function. J Sci Med Sport. 2014;17(1):139–43.PubMed
102.
Wyon MA, Koutedakis Y, Wolman R, et al. The influence of winter vitamin D supplementation on muscle function and injury occurrence in elite ballet dancers: a controlled study. J Sci Med Sport. 2014;17(1):8–12.PubMed
103.
Ceglia L. Vitamin D and skeletal muscle tissue and function. Mol Aspects Med. 2008;29(6):407–14.PubMed
104.
Haussler MR, Jurutka PW, Mizwicki M, et al. Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2)vitamin D(3): genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. 2011;25(4):543–59.PubMed
105.
Boland R, Norman A, Ritz E, et al. Presence of a 1,25-dihydroxy-vitamin D3 receptor in chick skeletal muscle myoblasts. Biochem Biophys Res Commun. 1985;128(1):305–11.PubMed
106.
Simpson RU, Thomas GA, Arnold AJ. Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem. 1985;260(15):8882–91.PubMed
107.
Costa EM, Blau HM, Feldman D. 1,25-dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells. Endocrinology. 1986;119(5):2214–20.PubMed
108.
Bischoff HA, Borchers M, Gudat F, et al. In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001;33(1):19–24.PubMed
109.
Bischoff-Ferrari HA, Borchers M, Gudat F, et al. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004;19(2):265–9.PubMed
110.
Wang Y, Deluca HF. Is the vitamin D receptor found in muscle? Endocrinology. 2011;152(2):354–63.PubMed
111.
Girgis CM, Mokbel N, Minn Cha K, et al. The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology. 2014; Epub ahead of print.
112.
de Boland AR, Boland RL. Rapid changes in skeletal muscle calcium uptake induced in vitro by 1,25-dihydroxyvitamin D3 are suppressed by calcium channel blockers. Endocrinology. 1987;120(5):1858–64.PubMed
113.
Selles J, Boland R. Rapid stimulation of calcium uptake and protein phosphorylation in isolated cardiac muscle by 1,25-dihydroxyvitamin D3. Mol Cell Endocrinol. 1991;77(1–3):67–73.PubMed
114.
Sato Y, Iwamoto J, Kanoko T, et al. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis. 2005;20(3):187–92.PubMed
115.
Girgis CM, Clifton-Bligh RJ, Mokbel N, et al. Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells. Endocrinology. 2014;155(2):347–57.PubMed
116.
Bhat M, Kalam R, Qadri SS, et al. Vitamin D deficiency-induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats. Endocrinology. 2013;154(11):4018–29.PubMed
117.
Kottler ML. Is vitamin D a key factor in muscle health? Endocrinology. 2013;154(11):3963–4.PubMed
118.
Foo LH, Zhang Q, Zhu K, et al. Low vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in chinese adolescent girls. J Nutr. 2009;139(5):1002–7.PubMed
119.
Gomez-Alonso C, Naves-Diaz ML, Fernandez-Martin JL, et al. Vitamin D status and secondary hyperparathyroidism: the importance of 25-hydroxyvitamin D cut-off levels. Kidney Int Suppl. 2003;85:S44–8.PubMed
120.
Miura A, Sato H, Whipp BJ, et al. The effect of glycogen depletion on the curvature constant parameter of the power-duration curve for cycle ergometry. Ergonomics. 2000;43(1):133–41.PubMed
121.
122.
Smogorzewski M, Piskorska G, Borum PR, et al. Chronic renal failure, parathyroid hormone and fatty acids oxidation in skeletal muscle. Kidney Int. 1988;33(2):555–60.PubMed
123.
Sinha A, Hollingsworth KG, Ball S, et al. Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. J Clin Endocrinol Metab. 2013;98(3):E509–13.PubMed
124.
Bouillon R, Verstuyf A. Vitamin D, mitochondria, and muscle. J Clin Endocrinol Metab. 2013;98(3):961–3.PubMed
125.
Tague SE, Smith PG. Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: modulation by ovarian hormones. J Chem Neuroanat. 2011;41(1):1–12.PubMedCentralPubMed
126.
127.
Tague SE, Clarke GL, Winter MK, et al. Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation. J Neurosci. 2011;31(39):13728–38.PubMedCentralPubMed
128.
Saleh FN, Schirmer H, Sundsfjord J, et al. Parathyroid hormone and left ventricular hypertrophy. Eur Heart J. 2003;24(22):2054–60.PubMed
129.
McCarty MF. Nutritional modulation of parathyroid hormone secretion may influence risk for left ventricular hypertrophy. Med Hypotheses. 2005;64(5):1015–21.PubMed
130.
Westerblad H, Allen DG, Lannergren J. Muscle fatigue: lactic acid or inorganic phosphate the major cause? News Physiol Sci. 2002;17:17–21.PubMed
131.
Gorostiaga EM, Navarro-Amezqueta I, Calbet JA, et al. Energy metabolism during repeated sets of leg press exercise leading to failure or not. PLoS One. 2012;7(7):e40621.PubMedCentralPubMed
132.
van Ballegooijen AJ, Visser M, Cotch MF, et al. Serum vitamin D and parathyroid hormone in relation to cardiac structure and function: the ICELAND-MI substudy of AGES-Reykjavik. J Clin Endocrinol Metab. 2013;98(6):2544–52.PubMedCentralPubMed
133.
Baggish AL, Wood MJ. Athlete’s heart and cardiovascular care of the athlete: scientific and clinical update. Circulation. 2011;123(23):2723–5.PubMed
134.
Katholi RE, Couri DM. Left ventricular hypertrophy: major risk factor in patients with hypertension: update and practical clinical applications. Int J Hypertens. 2011;2011:495349.PubMedCentralPubMed
135.
Allison RJ, Close GL, Farooq A, et al. Severely vitamin D-deficient athletes present smaller hearts than sufficient athletes. Eur J Prev Cardiol. 2014 (Epub ahead of print).
136.
Chinellato I, Piazza M, Sandri M, et al. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 2011;158(3):437–41.PubMed
137.
Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third National Health and Nutrition Examination Survey. Chest. 2005;128(6):3792–8.PubMed
138.
Rehan VK, Torday JS, Peleg S, et al. 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells. Mol Genet Metab. 2002;76(1):46–56.PubMed
139.
Vedala SR, Paul N, Mane AB. Difference in pulmonary function test among the athletic and sedentary population. Natl J Physiol Pharm Pharmacol. 2013;3(2):118–23.
140.
Ardestani A, Parker B, Mathur S, et al. Relation of vitamin D level to maximal oxygen uptake in adults. Am J Cardiol. 2011;107(8):1246–9.PubMed
141.
Mowry DA, Costello MM, Heelan KA. Association among cardiorespiratory fitness, body fat, and bone marker measurements in healthy young females. J Am Osteopath Assoc. 2009;109(10):534–9.PubMed
142.
Gregory SM, Parker BA, Capizzi JA, et al. Changes in vitamin D are not associated with changes in cardiorespiratory fitness. Clin Med Res. 2013;2(4):68–72.
143.
Forney LA, Earnest CP, Henagan TM, et al. Vitamin D status, body composition, and fitness measures in college-aged students. J Strength Cond Res. 2014;28(3):814–24.PubMed
144.
Alessio HM, Hagerman AE, Fulkerson BK, et al. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med Sci Sports Exerc. 2000;32(9):1576–81.PubMed
145.
Gleeson M. Immune function in sport and exercise. J Appl Physiol. 2007;103(2):693–9.PubMed
146.
Sureda A, Ferrer MD, Tauler P, et al. Effects of exercise intensity on lymphocyte H2O2 production and antioxidant defences in soccer players. Br J Sports Med. 2009;43(3):186–90.PubMed
147.
Kakanis MW, Peake J, Brenu EW, et al. The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. Exerc Immunol Rev. 2010;16:119–37.PubMed
148.
Shephard RJ, Shek PN. Effects of exercise and training on natural killer cell counts and cytolytic activity: a meta-analysis. Sports Med. 1999;28(3):177–95.PubMed
149.
Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. part one: immune function and exercise. Exerc Immunol Rev. 2011;17:6–63.PubMed
150.
Schleithoff SS, Zittermann A, Tenderich G, et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006;83(4):754–9.PubMed
151.
Peterson CA, Heffernan ME. Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. J Inflamm. 2008;24(5):10.
152.
Adams JS, Ren S, Liu PT, et al. Vitamin D-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 2009;182(7):4289–95.PubMedCentralPubMed
153.
Yusupov E, Li-Ng M, Pollack S, et al. Vitamin D and serum cytokines in a randomized clinical trial. Int J Endocrinol. 2010;2010:pii: 305054.
154.
Barnes MS, Horigan G, Cashman KD, et al. Maintenance of wintertime vitamin D status with cholecalciferol supplementation is not associated with alterations in serum cytokine concentrations among apparently healthy younger or older adults. J Nutr. 2011;141(3):476–81.PubMed
155.
Khoo AL, Chai LY, Koenen HJ, et al. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clin Exp Immunol. 2011;164(1):72–9.PubMedCentralPubMed
156.
Barker T, Martins TB, Hill HR, et al. Different doses of supplemental vitamin D maintain interleukin-5 without altering skeletal muscle strength: a randomized, double-blind, placebo-controlled study in vitamin D sufficient adults. Nutr Metab (Lond). 2012;9(1):16.
157.
Willis KS, Smith DT, Broughton KS, et al. Vitamin D status and biomarkers of inflammation in runners. Open Access J Sports Med. 2012;3:35–42.PubMedCentralPubMed
158.
He C, Handzlik M, Fraser WD, et al. Influence of vitamin D status on respiratory infection incidence and immune function during 4 months of winter training in endurance sport athletes. Exerc Immunol Rev. 2013;19:86–101.PubMed
159.
He C, Fraser WD, Gleeson M. Influence of vitamin D metabolites on plasma cytokine concentrations in endurance sport athletes and on multiantigen stimulated cytokine production by whole blood and peripheral blood mononuclear cell cultures. ISRN Nutr. 2014;2014:820524.PubMedCentralPubMed
160.
van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005;97(1–2):93–101.PubMed
161.
Dixon BM, Barker T, McKinnon T, et al. Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults. BMC Res Notes. 2012;24(5):575.
162.
Autier P, Boniol M, Pizot C, et al. Vitamin D status and ill health: a systematic review. Lancet Diab Endo. 2014;2(1):76–89.
163.
Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J. 2001;15(14):2579–85.PubMed
164.
165.
Shab-Bidar S, Neyestani TR, Djazayery A, et al. Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes. Diabetes Metab Res Rev. 2012;28(5):424–30.PubMed
166.
Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012;188(5):2127–35.PubMedCentralPubMed
167.
Larson-Meyer DE, Willis KS. Vitamin D and athletes. Curr Sports Med Rep. 2010;9(4):220–6.PubMed
168.
Mastorakos G, Pavlatou M, Diamanti-Kandarakis E, et al. Exercise and the stress system. Hormones. 2005;4(2):73–89.PubMed
169.
Calle MC, Fernandez ML. Effects of resistance training on the inflammatory response. Nutr Res Pract. 2010;4(4):259–69.PubMedCentralPubMed
170.
Cantorna MT, Zhu Y, Froicu M, et al. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80(6 Suppl):1717S–20S.PubMed
171.
Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39(2):365–79.PubMedCentralPubMed
172.
Jeffery LE, Wood AM, Qureshi OS, et al. Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J Immunol. 2012;189(11):5155–64.PubMedCentralPubMed
173.
Hewison M, Freeman L, Hughes SV, et al. Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol. 2003;170(11):5382–90.PubMed
174.
Prietl B, Pilz S, Wolf M, et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr Med Assoc J. 2010;12(3):136–9.PubMed
175.
Bock G, Prietl B, Mader JK, et al. The effect of vitamin D supplementation on peripheral regulatory T cells and beta cell function in healthy humans: a randomized controlled trial. Diabetes Metab Res Rev. 2011;27(8):942–5.PubMed
176.
Peterson RA. Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression. Toxicol Pathol. 2012;40(2):186–204.PubMed
177.
Spence L, Brown WJ, Pyne DB, et al. Incidence, etiology, and symptomatology of upper respiratory illness in elite athletes. Med Sci Sports Exerc. 2007;39(4):577–86.PubMed
178.
White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008;76(9):3837–43.PubMedCentralPubMed
179.
Di Nardo A, Vitiello A, Gallo RL. Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide. J Immunol. 2003;170(5):2274–8.PubMed
180.
Guo C, Sinnott B, Niu B, et al. Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol Nutr Food Res. 2014;58(3):528–36.PubMed
181.
Vandamme D, Landuyt B, Luyten W, et al. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 2012;280(1):22–35.PubMed
182.
Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770–3.PubMed
183.
Shirakawa AK, Nagakubo D, Hieshima K, et al. 1,25-dihydroxyvitamin D3 induces CCR10 expression in terminally differentiating human B cells. J Immunol. 2008;180(5):2786–95.PubMed
184.
Xiong N, Fu Y, Hu S, et al. CCR10 and its ligands in regulation of epithelial immunity and diseases. Protein Cell. 2012;3(8):571–80.PubMed
Metadata
Title
Vitamin D: Recent Advances and Implications for Athletes
Authors
Joshua J. Todd
L. Kirsty Pourshahidi
Emeir M. McSorley
Sharon M. Madigan
Pamela J. Magee
Publication date
01-02-2015
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 2/2015
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-014-0266-7

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