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Published in: PharmacoEconomics 4/2018

01-04-2018 | Original Research Article

Mapping the Paediatric Quality of Life Inventory (PedsQL™) Generic Core Scales onto the Child Health Utility Index–9 Dimension (CHU-9D) Score for Economic Evaluation in Children

Authors: Tosin Lambe, Emma Frew, Natalie J. Ives, Rebecca L. Woolley, Carole Cummins, Elizabeth A. Brettell, Emma N. Barsoum, Nicholas J. A. Webb, On behalf of the PREDNOS Trial Team

Published in: PharmacoEconomics | Issue 4/2018

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Abstract

Background

The Paediatric Quality of Life Inventory (PedsQL™) questionnaire is a widely used, generic instrument designed for measuring health-related quality of life (HRQoL); however, it is not preference-based and therefore not suitable for cost–utility analysis. The Child Health Utility Index–9 Dimension (CHU-9D), however, is a preference-based instrument that has been primarily developed to support cost–utility analysis.

Objective

This paper presents a method for estimating CHU-9D index scores from responses to the PedsQL™ using data from a randomised controlled trial of prednisolone therapy for treatment of childhood corticosteroid-sensitive nephrotic syndrome.

Methods

HRQoL data were collected from children at randomisation, week 16, and months 12, 18, 24, 36 and 48. Observations on children aged 5 years and older were pooled across all data collection timepoints and were then randomised into an estimation (n = 279) and validation (n = 284) sample. A number of models were developed using the estimation data before internal validation. The best model was chosen using multi-stage selection criteria.

Results

Most of the models developed accurately predicted the CHU-9D mean index score. The best performing model was a generalised linear model (mean absolute error = 0.0408; mean square error = 0.0035). The proportion of index scores deviating from the observed scores by <  0.03 was 53%.

Conclusions

The mapping algorithm provides an empirical tool for estimating CHU-9D index scores and for conducting cost–utility analyses within clinical studies that have only collected PedsQL™ data. It is valid for children aged 5 years or older. Caution should be exercised when using this with children younger than 5 years, older adolescents (>  13 years) or patient groups with particularly poor quality of life.

ISRCTN Registry No

16645249
Appendix
Available only for authorised users
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Metadata
Title
Mapping the Paediatric Quality of Life Inventory (PedsQL™) Generic Core Scales onto the Child Health Utility Index–9 Dimension (CHU-9D) Score for Economic Evaluation in Children
Authors
Tosin Lambe
Emma Frew
Natalie J. Ives
Rebecca L. Woolley
Carole Cummins
Elizabeth A. Brettell
Emma N. Barsoum
Nicholas J. A. Webb
On behalf of the PREDNOS Trial Team
Publication date
01-04-2018
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 4/2018
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.1007/s40273-017-0600-7

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