Skip to main content
Top
Published in: CNS Drugs 4/2019

01-04-2019 | Therapy in Practice

Skin-Picking Disorder: A Guide to Diagnosis and Management

Authors: Mohammad Jafferany, Arsh Patel

Published in: CNS Drugs | Issue 4/2019

Login to get access

Abstract

Skin-picking disorder, also known as excoriation disorder or psychogenic skin excoriations, is an obsessive–compulsive and related disorder that is classified with other body-focused repetitive-behavior disorders in the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Skin-picking disorder is associated with significant comorbidity and psychosocial dysfunction. The disorder has a female predominance across studies, and the average age of onset is variable but commonly in adolescence and adulthood. A full clinical and dermatologic examination and multidisciplinary approach is important in the diagnosis of this condition. There is no specific or recommended treatment option, but cognitive–behavioral therapy, particularly habit-reversal therapy and acceptance and commitment therapy have shown promise. Various pharmacological interventions have also been described to treat this condition in case reports and open and controlled trials. Specific classes of agents implemented include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors, antipsychotics, and glutaminergic-modulating agents. SSRIs and N-acetylcysteine have been shown to be the most effective of the pharmacological interventions.
Literature
1.
2.
go back to reference Wilson E. Lectures on dermatology. Delivered in the Royal College of Surgeons of England, 1874–1875. London: J and A Churhil; 1875. Wilson E. Lectures on dermatology. Delivered in the Royal College of Surgeons of England, 1874–1875. London: J and A Churhil; 1875.
3.
go back to reference Bach M, Bach D. Psychiatric and psychometric issues in acné excoriée. Psychother Psychosom. 1993;60(3–4):207–10.PubMedCrossRef Bach M, Bach D. Psychiatric and psychometric issues in acné excoriée. Psychother Psychosom. 1993;60(3–4):207–10.PubMedCrossRef
4.
go back to reference Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Washington DC: American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Washington DC: American Psychiatric Association. 2013.
5.
go back to reference Misery L, Chastaing M, Touboul S, et al. Psychogenic skin excoriations: diagnostic criteria, semiological analysis and psychiatric profiles. Acta Derm Venereol. 2012;92(4):416–8.PubMedCrossRef Misery L, Chastaing M, Touboul S, et al. Psychogenic skin excoriations: diagnostic criteria, semiological analysis and psychiatric profiles. Acta Derm Venereol. 2012;92(4):416–8.PubMedCrossRef
6.
go back to reference Koo JYM, Lee CS. General approach to evaluating psychodermatological disorders. In: Koo JYM, Lee CS, editors. Psychocutaneous medicine. New York: Marcel Dekker, Inc.; 2003. p. 1–29. Koo JYM, Lee CS. General approach to evaluating psychodermatological disorders. In: Koo JYM, Lee CS, editors. Psychocutaneous medicine. New York: Marcel Dekker, Inc.; 2003. p. 1–29.
7.
go back to reference Jafferany M, Franca K. Psychodermatology: basics concepts. Acta Derm Venereol. 2016;96(217):35–7.PubMed Jafferany M, Franca K. Psychodermatology: basics concepts. Acta Derm Venereol. 2016;96(217):35–7.PubMed
8.
go back to reference Houghton DC, Alexander JR, Bauer CC, et al. Body-focused repetitive behaviors: more prevalent than once thought? Psychiatry Res. 2018;2(270):389–93.CrossRef Houghton DC, Alexander JR, Bauer CC, et al. Body-focused repetitive behaviors: more prevalent than once thought? Psychiatry Res. 2018;2(270):389–93.CrossRef
9.
go back to reference Hayes SL, Storch EA, Berlanga L. Skin picking behaviors: an examination of the prevalence and severity in a community sample. J Anxiety Disord. 2009;23(3):314–9.PubMedCrossRef Hayes SL, Storch EA, Berlanga L. Skin picking behaviors: an examination of the prevalence and severity in a community sample. J Anxiety Disord. 2009;23(3):314–9.PubMedCrossRef
10.
go back to reference Keuthen NJ, Koran LM, Aboujaoude E, Large MD, Serpe RT. The prevalence of pathologic skin picking in US adults. Compr Psychiatry. 2010;51(2):183–6.PubMedCrossRef Keuthen NJ, Koran LM, Aboujaoude E, Large MD, Serpe RT. The prevalence of pathologic skin picking in US adults. Compr Psychiatry. 2010;51(2):183–6.PubMedCrossRef
11.
go back to reference Machado MO, Köhler CA, Stubbs B, et al. Skin picking disorder: prevalence, correlates, and associations with quality of life in a large sample. CNS Spectr. 2018;23(5):311–20.PubMedCrossRef Machado MO, Köhler CA, Stubbs B, et al. Skin picking disorder: prevalence, correlates, and associations with quality of life in a large sample. CNS Spectr. 2018;23(5):311–20.PubMedCrossRef
12.
go back to reference Ricketts EJ, Snorrason Í, Kircanski K, et al. A latent profile analysis of age of onset in pathological skin picking. Compr Psychiatry. 2018;87:46–52.PubMedCrossRef Ricketts EJ, Snorrason Í, Kircanski K, et al. A latent profile analysis of age of onset in pathological skin picking. Compr Psychiatry. 2018;87:46–52.PubMedCrossRef
13.
go back to reference Gupta A, Jafferany M. Psychocutaneous disease. In: Sadock BJ, Sadock VA, Ruiz P, editors. Kaplan and Sadock’s comprehensive textbook of psychiatry. 10th ed. Philadelphia: Lippincott William & Wilkins; 2000. Gupta A, Jafferany M. Psychocutaneous disease. In: Sadock BJ, Sadock VA, Ruiz P, editors. Kaplan and Sadock’s comprehensive textbook of psychiatry. 10th ed. Philadelphia: Lippincott William & Wilkins; 2000.
14.
go back to reference Cyr PR, Dreher GK. Neurotic excoriations. Am Fam Physician. 2001;64(12):1981–4.PubMed Cyr PR, Dreher GK. Neurotic excoriations. Am Fam Physician. 2001;64(12):1981–4.PubMed
15.
go back to reference Lochner C, Roos A, Stein DJ. Excoriation (skin-picking) disorder: a systematic review of treatment options. Neuropsychiatr Dis Treat. 2017;14(13):1867–72.CrossRef Lochner C, Roos A, Stein DJ. Excoriation (skin-picking) disorder: a systematic review of treatment options. Neuropsychiatr Dis Treat. 2017;14(13):1867–72.CrossRef
16.
go back to reference Odlaug BL, Grant JE. Pathologic skin picking. In: Grant JE, Stein DJ, Woods DW, Keuthen NJ, editors. Trichotillomania, Skin Picking and Other Body-Focused Repetitive Behaviors. Washington, DC: American Psychiatric Publishing Inc; 2012. p. 21–41. Odlaug BL, Grant JE. Pathologic skin picking. In: Grant JE, Stein DJ, Woods DW, Keuthen NJ, editors. Trichotillomania, Skin Picking and Other Body-Focused Repetitive Behaviors. Washington, DC: American Psychiatric Publishing Inc; 2012. p. 21–41.
17.
go back to reference Solley K, Turner C. Prevalence and correlates of clinically significant body-focused repetitive behaviors in a non-clinical sample. Compr Psychiatry. 2018;86:9–18.PubMedCrossRef Solley K, Turner C. Prevalence and correlates of clinically significant body-focused repetitive behaviors in a non-clinical sample. Compr Psychiatry. 2018;86:9–18.PubMedCrossRef
18.
go back to reference Sampaio DG, Grant JE. Body-focused repetitive behaviors and the dermatology patient. Clin Dermatol. 2018;36(6):723–7.PubMedCrossRef Sampaio DG, Grant JE. Body-focused repetitive behaviors and the dermatology patient. Clin Dermatol. 2018;36(6):723–7.PubMedCrossRef
19.
go back to reference Odlaug BL, Kim SW, Grant JE. Quality of life and clinical severity in pathological skin picking and trichotillomania. J Anxiety Disord. 2010;24(8):823–9.PubMedCrossRef Odlaug BL, Kim SW, Grant JE. Quality of life and clinical severity in pathological skin picking and trichotillomania. J Anxiety Disord. 2010;24(8):823–9.PubMedCrossRef
20.
go back to reference Snorrason I, Smári J, Olafsson RP. Emotion regulation in pathological skin picking: findings from a non-treatment seeking sample. J Behav Ther Exp Psychiatry. 2010;41(3):238–45.PubMedCrossRef Snorrason I, Smári J, Olafsson RP. Emotion regulation in pathological skin picking: findings from a non-treatment seeking sample. J Behav Ther Exp Psychiatry. 2010;41(3):238–45.PubMedCrossRef
21.
go back to reference Flessner CA, Woods DW. Phenomenological characteristics, social problems, and the economic impact associated with chronic skin picking. Behav Modif. 2006;30(6):944–63.PubMedCrossRef Flessner CA, Woods DW. Phenomenological characteristics, social problems, and the economic impact associated with chronic skin picking. Behav Modif. 2006;30(6):944–63.PubMedCrossRef
22.
go back to reference Mutasim DF, Adams BB. The psychiatric profile of patients with psychogenic excoriation. J Am Acad Dermatol. 2009;61(4):611–3.PubMedCrossRef Mutasim DF, Adams BB. The psychiatric profile of patients with psychogenic excoriation. J Am Acad Dermatol. 2009;61(4):611–3.PubMedCrossRef
23.
go back to reference Gupta M. Body-focused repetitive behaviors (BFRB) (trichotillomania, skin picking, onychophagia) and eating disorders (ED): Preliminary findings in a nondermatologic sample. J Am Acad Dermatol. 2016;74(5):46. Gupta M. Body-focused repetitive behaviors (BFRB) (trichotillomania, skin picking, onychophagia) and eating disorders (ED): Preliminary findings in a nondermatologic sample. J Am Acad Dermatol. 2016;74(5):46.
24.
go back to reference Neziroglu F, Rabinowitz D, Breytman A, et al. Skin picking phenomenology and severity comparison. Prim Care Companion J Clin Psychiatry. 2008;10(4):306–12.PubMedPubMedCentralCrossRef Neziroglu F, Rabinowitz D, Breytman A, et al. Skin picking phenomenology and severity comparison. Prim Care Companion J Clin Psychiatry. 2008;10(4):306–12.PubMedPubMedCentralCrossRef
25.
go back to reference Tucker BT, Woods DW, Flessner CA, et al. The Skin Picking Impact Project: phenomenology, interference, and treatment utilization of pathological skin picking in a population-based sample. J Anxiety Disord. 2011;25(1):88–95.PubMedCrossRef Tucker BT, Woods DW, Flessner CA, et al. The Skin Picking Impact Project: phenomenology, interference, and treatment utilization of pathological skin picking in a population-based sample. J Anxiety Disord. 2011;25(1):88–95.PubMedCrossRef
26.
go back to reference Koblenzer CS, Gupta R. Neurotic excoriations and dermatitis artefacta. Semin Cutan Med Surg. 2013;32(2):95–100.PubMedCrossRef Koblenzer CS, Gupta R. Neurotic excoriations and dermatitis artefacta. Semin Cutan Med Surg. 2013;32(2):95–100.PubMedCrossRef
27.
go back to reference Jafferany M, Stoep AV, Dumitrescu A, Hornung RL. Psychocutaneous dis- orders: a survey study of psychiatrists’ awareness and treatment patterns. South Med J. 2010;103:1199–203.PubMedCrossRef Jafferany M, Stoep AV, Dumitrescu A, Hornung RL. Psychocutaneous dis- orders: a survey study of psychiatrists’ awareness and treatment patterns. South Med J. 2010;103:1199–203.PubMedCrossRef
28.
go back to reference Jafferany M, Stoep AV, Dumitrescu A, Hornung RL. The knowledge, awareness, and practice patterns of dermatologists toward psychocutaneous dis- orders: results of a survey study. Int J Dermatol. 2010;49:784–9.PubMedCrossRef Jafferany M, Stoep AV, Dumitrescu A, Hornung RL. The knowledge, awareness, and practice patterns of dermatologists toward psychocutaneous dis- orders: results of a survey study. Int J Dermatol. 2010;49:784–9.PubMedCrossRef
29.
go back to reference Franklin ME, Tolin DF. In treating trichotillomania: cognitive behavioral therapy for hair pulling and related problems. New York: Springer; 2010. p. 51. Franklin ME, Tolin DF. In treating trichotillomania: cognitive behavioral therapy for hair pulling and related problems. New York: Springer; 2010. p. 51.
30.
go back to reference Teng EJ, Woods DW, Twohig MP. Habit reversal as a treatment for chronic skin picking: a pilot investigation. Behav Modif. 2006;30(4):411–22.PubMedCrossRef Teng EJ, Woods DW, Twohig MP. Habit reversal as a treatment for chronic skin picking: a pilot investigation. Behav Modif. 2006;30(4):411–22.PubMedCrossRef
31.
go back to reference Mouton SG, Stanley MA. Habit reversal training for trichotillomania: a group approach. Cogn Behav Pract. 1999;3(1):159–82.CrossRef Mouton SG, Stanley MA. Habit reversal training for trichotillomania: a group approach. Cogn Behav Pract. 1999;3(1):159–82.CrossRef
32.
go back to reference Lerner J, Franklin ME, Meadows EA, et al. Effectiveness of a cognitive behavioral treatment program fro trichotillomania: an uncontrolled evaluation. Behav Ther. 1998;29(1):157–71.CrossRef Lerner J, Franklin ME, Meadows EA, et al. Effectiveness of a cognitive behavioral treatment program fro trichotillomania: an uncontrolled evaluation. Behav Ther. 1998;29(1):157–71.CrossRef
33.
go back to reference Van Minnen A, Hoogduin KA, Keijsers GP. Treatment of trichotillomania with behavioral therapy or fluoxetine: a randomized, waiting-list controlled study. Arch Gen Psychiatry. 2003;60(5):517–22.PubMedCrossRef Van Minnen A, Hoogduin KA, Keijsers GP. Treatment of trichotillomania with behavioral therapy or fluoxetine: a randomized, waiting-list controlled study. Arch Gen Psychiatry. 2003;60(5):517–22.PubMedCrossRef
34.
go back to reference Woods DW, Wetterneck CT, Flessner CA. A controlled evaluation of acceptance and commitment therapy plus habit reversal for trichotillomania. Behav Res Ther. 2006;44(5):639–56.PubMedCrossRef Woods DW, Wetterneck CT, Flessner CA. A controlled evaluation of acceptance and commitment therapy plus habit reversal for trichotillomania. Behav Res Ther. 2006;44(5):639–56.PubMedCrossRef
35.
go back to reference Keuthen NJ, Rothbaum BO, Falkenstein MJ, et al. DBT-enhanced habit reversal treatment for trichotillomania: 3- and 6-month follow up results. Depress Anxiety. 2011;28(4):310–3.PubMedCrossRef Keuthen NJ, Rothbaum BO, Falkenstein MJ, et al. DBT-enhanced habit reversal treatment for trichotillomania: 3- and 6-month follow up results. Depress Anxiety. 2011;28(4):310–3.PubMedCrossRef
36.
go back to reference Relaxation Shenefelt PD. meditation and hypnosis for skin disorders and procedure. In: de Luca BN, editor. Mind-body and relaxation research focus. Hauppauge: Nova Science Publishers; 2008. p. 45–63. Relaxation Shenefelt PD. meditation and hypnosis for skin disorders and procedure. In: de Luca BN, editor. Mind-body and relaxation research focus. Hauppauge: Nova Science Publishers; 2008. p. 45–63.
37.
go back to reference Flessner CA, Busch AM, Heideman PW, et al. Acceptance-enhanced behavior therapy (AEBT) for trichotillomania and chronic skin picking: exploring the effects of component sequencing. Behav Modif. 2008;32:579–94.PubMedCrossRef Flessner CA, Busch AM, Heideman PW, et al. Acceptance-enhanced behavior therapy (AEBT) for trichotillomania and chronic skin picking: exploring the effects of component sequencing. Behav Modif. 2008;32:579–94.PubMedCrossRef
39.
go back to reference Hayes SC. Acceptance and Commitment Therapy and the New Behavior Therapies: Mindfulness, Acceptance, and Relationship. In: Hayes SC, Follette VM, Linehan MM, editors. Mindfulness and acceptance: Expanding the cognitive-behavioral tradition. New York: Guilford Press; 2004. p. 1–29. Hayes SC. Acceptance and Commitment Therapy and the New Behavior Therapies: Mindfulness, Acceptance, and Relationship. In: Hayes SC, Follette VM, Linehan MM, editors. Mindfulness and acceptance: Expanding the cognitive-behavioral tradition. New York: Guilford Press; 2004. p. 1–29.
40.
go back to reference Fjorback LO. Mindfulness and body distress. Dan Med J. 2012;59:B4547.PubMed Fjorback LO. Mindfulness and body distress. Dan Med J. 2012;59:B4547.PubMed
42.
go back to reference Schumer MC, Bartley CA, Bloch MH. Systematic review of pharmacological and behavioral treatments of skin picking disorder. J Clin Psychopharmacol. 2016;36(2):147–52.PubMedPubMedCentralCrossRef Schumer MC, Bartley CA, Bloch MH. Systematic review of pharmacological and behavioral treatments of skin picking disorder. J Clin Psychopharmacol. 2016;36(2):147–52.PubMedPubMedCentralCrossRef
43.
go back to reference Gelinas BL, Gagnon MM. Pharmacological and psychological treatments of pathological skin-picking: a preliminary meta-analysis. J Obsessive Compuls Rel Disord. 2013;2(2):167–75.CrossRef Gelinas BL, Gagnon MM. Pharmacological and psychological treatments of pathological skin-picking: a preliminary meta-analysis. J Obsessive Compuls Rel Disord. 2013;2(2):167–75.CrossRef
44.
go back to reference Selles RR, McGuire JF, Small BJ. A systematic review and meta-analysis of psychiatric treatments for excoriation (skin-picking) disorder. Gen Hosp Psychiatry. 2016;41:29–37.PubMedCrossRef Selles RR, McGuire JF, Small BJ. A systematic review and meta-analysis of psychiatric treatments for excoriation (skin-picking) disorder. Gen Hosp Psychiatry. 2016;41:29–37.PubMedCrossRef
45.
go back to reference Simeon D, Stein DJ, Gross S, et al. A double -blind trial of fluoxetine in pathological skin picking. J Clin Psychiatry. 1997;58:341–7.PubMedCrossRef Simeon D, Stein DJ, Gross S, et al. A double -blind trial of fluoxetine in pathological skin picking. J Clin Psychiatry. 1997;58:341–7.PubMedCrossRef
46.
go back to reference Sharma H. Psychogenic excoriation responding to fluoxetine; A case report. J Indian Med Assoc. 2008;106(4):245–62.PubMed Sharma H. Psychogenic excoriation responding to fluoxetine; A case report. J Indian Med Assoc. 2008;106(4):245–62.PubMed
47.
go back to reference Bloch MR, Elliott M, Thompson H, et al. Fluoxetine in pathological skin picking: open label and double-blind results. Psychosomatics. 2001;42(4):314–9.PubMedCrossRef Bloch MR, Elliott M, Thompson H, et al. Fluoxetine in pathological skin picking: open label and double-blind results. Psychosomatics. 2001;42(4):314–9.PubMedCrossRef
48.
go back to reference Keuthen NJ, Jameson M, Loh R, et al. Open label trial of Escitalopram treatment for pathological skin picking. Int Clin Psychopharmacol. 2007;22(5):268–74.PubMedCrossRef Keuthen NJ, Jameson M, Loh R, et al. Open label trial of Escitalopram treatment for pathological skin picking. Int Clin Psychopharmacol. 2007;22(5):268–74.PubMedCrossRef
49.
go back to reference Arbabi M, Farnia V, Balighi K, et al. Efficiency of Citalopram in treatment of pathological skin picking: a randomized double-blind placebo controlled trial. Acta Med Iran. 2008;46(5):367–72. Arbabi M, Farnia V, Balighi K, et al. Efficiency of Citalopram in treatment of pathological skin picking: a randomized double-blind placebo controlled trial. Acta Med Iran. 2008;46(5):367–72.
50.
go back to reference Kalivas J, Kalivas L, Gilman D, et al. Sertraline in the treatment of neurotic excoriations and related disorders. Arch Dermatol. 1996;132(5):589–90.PubMedCrossRef Kalivas J, Kalivas L, Gilman D, et al. Sertraline in the treatment of neurotic excoriations and related disorders. Arch Dermatol. 1996;132(5):589–90.PubMedCrossRef
51.
go back to reference Biondi M, Arcangeli T, Petrucci RM. Paroxetine in a case of psychogenic pruritus and neurotic excoriation. Psychother Psychosom. 2000;69:165–6.PubMedCrossRef Biondi M, Arcangeli T, Petrucci RM. Paroxetine in a case of psychogenic pruritus and neurotic excoriation. Psychother Psychosom. 2000;69:165–6.PubMedCrossRef
52.
go back to reference Ravindran AV, Lapierre YD, Anisman H. Obsessive compulsive spectrum disorders:effective treatment with paroxetine. Can J Psychiatry. 1999;44:805–7.PubMedCrossRef Ravindran AV, Lapierre YD, Anisman H. Obsessive compulsive spectrum disorders:effective treatment with paroxetine. Can J Psychiatry. 1999;44:805–7.PubMedCrossRef
53.
go back to reference Harris BA, Sherertz EF, Flowers FP. Improvement of chronic neurotic excoriations with oral doxepin therapy. Int J Dermatol. 1978;26:541–3.CrossRef Harris BA, Sherertz EF, Flowers FP. Improvement of chronic neurotic excoriations with oral doxepin therapy. Int J Dermatol. 1978;26:541–3.CrossRef
54.
go back to reference Arnold LM, Mutasim DF, Dwight MM, et al. An open clinical trial of fluvoxamine treatment of psychogenic excoriation. J Clin Psychopharmacol. 1999;19(1):15–8.PubMedCrossRef Arnold LM, Mutasim DF, Dwight MM, et al. An open clinical trial of fluvoxamine treatment of psychogenic excoriation. J Clin Psychopharmacol. 1999;19(1):15–8.PubMedCrossRef
56.
go back to reference Roi C, Bazzano A. Improvement in skin excoriation (skin picking) with use of Risperidone in a patient with developmental diability. Pediatr Rep. 2017;9(1):6946.PubMedPubMedCentralCrossRef Roi C, Bazzano A. Improvement in skin excoriation (skin picking) with use of Risperidone in a patient with developmental diability. Pediatr Rep. 2017;9(1):6946.PubMedPubMedCentralCrossRef
57.
go back to reference Christensen RC. Olanzapine augmentation of fluoxetine in the treatment of pathological skin picking. Can J Psychiatry. 2004;49(11):788–9.PubMedCrossRef Christensen RC. Olanzapine augmentation of fluoxetine in the treatment of pathological skin picking. Can J Psychiatry. 2004;49(11):788–9.PubMedCrossRef
58.
go back to reference Garnis-Jones S, Collins S, Rosenthal D. Treatment of self-mutilation with Olanzapine. J Cut Med Surg. 2000;4(3):161–3. Garnis-Jones S, Collins S, Rosenthal D. Treatment of self-mutilation with Olanzapine. J Cut Med Surg. 2000;4(3):161–3.
59.
go back to reference Spiegel DR, Finklea L. The recognition and treatment of pathological skin picking. A potential neurobiological underpinning of the efficacy of pharmacotherapy in impulse control disorders. Psychiatry. 2009;6(2):38–42.PubMed Spiegel DR, Finklea L. The recognition and treatment of pathological skin picking. A potential neurobiological underpinning of the efficacy of pharmacotherapy in impulse control disorders. Psychiatry. 2009;6(2):38–42.PubMed
60.
go back to reference Pittenger C, Bloch MH, Williams K. Glutamate abnormalities in obsessive-compulsive disorder: neurobiology, pathophysiology and treatment. Phamacol Ther. 2011;132(3):314–32.CrossRef Pittenger C, Bloch MH, Williams K. Glutamate abnormalities in obsessive-compulsive disorder: neurobiology, pathophysiology and treatment. Phamacol Ther. 2011;132(3):314–32.CrossRef
61.
go back to reference Grados MA, Atkins EB, Kovacikova GI, et al. A selective review of glutamate pharmacological therapy in obsessive compulsive and related disorders. Psychol Res Behav Manag. 2015;8:115–31.PubMedPubMedCentralCrossRef Grados MA, Atkins EB, Kovacikova GI, et al. A selective review of glutamate pharmacological therapy in obsessive compulsive and related disorders. Psychol Res Behav Manag. 2015;8:115–31.PubMedPubMedCentralCrossRef
63.
go back to reference Asevedo E, Mendes AC, Berk M, et al. Systemic review of N-Acetylcysteine in the treatment of addictions. Rev Bras Psiquiatr. 2014;36(2):168–75.PubMedCrossRef Asevedo E, Mendes AC, Berk M, et al. Systemic review of N-Acetylcysteine in the treatment of addictions. Rev Bras Psiquiatr. 2014;36(2):168–75.PubMedCrossRef
64.
go back to reference Grant JE, Chamberlain SR, Redden SA, et al. N-Acetylcysteine in the treatment of excoriation disorder: a randomized clinical trial. JAMA Psychiatry. 2016;73(5):490–6.PubMedCrossRef Grant JE, Chamberlain SR, Redden SA, et al. N-Acetylcysteine in the treatment of excoriation disorder: a randomized clinical trial. JAMA Psychiatry. 2016;73(5):490–6.PubMedCrossRef
65.
go back to reference Silva-Netto R, Jesus G, Nogueora M, et al. N-Acetylcysteine in the treatment of skin picking disorder. Braz J Psychiatr. 2014;36(1):101.CrossRef Silva-Netto R, Jesus G, Nogueora M, et al. N-Acetylcysteine in the treatment of skin picking disorder. Braz J Psychiatr. 2014;36(1):101.CrossRef
66.
go back to reference Odlaug BL, Grant JE. N-Acetylcysteine in the treatment of grooming disorder. J Clin Psychopharmacol. 2007;27:227–9.PubMedCrossRef Odlaug BL, Grant JE. N-Acetylcysteine in the treatment of grooming disorder. J Clin Psychopharmacol. 2007;27:227–9.PubMedCrossRef
67.
go back to reference Grant JE, Odlaug BL, Kim SW. Lamoatrigine treatment of pathologic skin picking: an open label study. J Clin Psychiatry. 2007;68:1384–91.PubMedCrossRef Grant JE, Odlaug BL, Kim SW. Lamoatrigine treatment of pathologic skin picking: an open label study. J Clin Psychiatry. 2007;68:1384–91.PubMedCrossRef
68.
go back to reference Grant JE, Odlaug BL, Chamberlain SR, et al. A double-blind placebo-controlled trial of Lamotrigine for pathological skin picking: treatment efficacy and neurocognitive predictors of response. J Clin Psychopharmacol. 2010;30:396–403.PubMedPubMedCentralCrossRef Grant JE, Odlaug BL, Chamberlain SR, et al. A double-blind placebo-controlled trial of Lamotrigine for pathological skin picking: treatment efficacy and neurocognitive predictors of response. J Clin Psychopharmacol. 2010;30:396–403.PubMedPubMedCentralCrossRef
70.
go back to reference Bonnot O, Cohen D, Thuilleaux D, et al. Psychotropic treatments in Prader-Willi syndrome: a critical review of published literature. Eur J Periatr. 2016;175(1):9–18.CrossRef Bonnot O, Cohen D, Thuilleaux D, et al. Psychotropic treatments in Prader-Willi syndrome: a critical review of published literature. Eur J Periatr. 2016;175(1):9–18.CrossRef
72.
go back to reference Shapira NA, Lessig MC, Murphey TK, et al. Topiramate attenuate self-injurious behavior in Prader-Willi syndrome. Int J Neuropsychopharmacol. 2002;5(2):141–5.PubMedCrossRef Shapira NA, Lessig MC, Murphey TK, et al. Topiramate attenuate self-injurious behavior in Prader-Willi syndrome. Int J Neuropsychopharmacol. 2002;5(2):141–5.PubMedCrossRef
73.
go back to reference Sasso DA, Kalanithi PS, Trueblood KV, et al. Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors. J Clin Psychopharmacol. 2006;26(2):685–7.PubMedCrossRef Sasso DA, Kalanithi PS, Trueblood KV, et al. Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors. J Clin Psychopharmacol. 2006;26(2):685–7.PubMedCrossRef
74.
go back to reference Banga A, Conner DF. Effectiveness of Naltrexone for treating pathological skin picking behavior in an adolescent with Prader-Willi syndrome. J Child Adolesc Psychopharmacol. 2012;22(5):396–8.PubMedCrossRef Banga A, Conner DF. Effectiveness of Naltrexone for treating pathological skin picking behavior in an adolescent with Prader-Willi syndrome. J Child Adolesc Psychopharmacol. 2012;22(5):396–8.PubMedCrossRef
75.
go back to reference Benjamin E, Bout-Smith T. Naltrexone and fluoxetine in Prader-Willi syndrome. J Am Acad Child Adolesc Psychiatry. 1993;32(4):870–3.PubMedCrossRef Benjamin E, Bout-Smith T. Naltrexone and fluoxetine in Prader-Willi syndrome. J Am Acad Child Adolesc Psychiatry. 1993;32(4):870–3.PubMedCrossRef
76.
go back to reference Seedat S, Stein DJ, Harvey BH. Inositol in the treatment of trichotillomania and compulsive skin picking. J Clin Psychiatry. 2001;62(1):60–1.PubMedCrossRef Seedat S, Stein DJ, Harvey BH. Inositol in the treatment of trichotillomania and compulsive skin picking. J Clin Psychiatry. 2001;62(1):60–1.PubMedCrossRef
77.
go back to reference Jones G, Keuthen N, Greenberg E. Assessment and treatment of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder. Clin Dermatol. 2018;36:728–36.PubMedCrossRef Jones G, Keuthen N, Greenberg E. Assessment and treatment of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder. Clin Dermatol. 2018;36:728–36.PubMedCrossRef
78.
go back to reference Dunbar AB, Magid M, Reichenberg JS. Habit Reversal training for body focused repetitive behaviors. G Ital Dermatol Venereol. 2018;153(4):557–66.PubMed Dunbar AB, Magid M, Reichenberg JS. Habit Reversal training for body focused repetitive behaviors. G Ital Dermatol Venereol. 2018;153(4):557–66.PubMed
Metadata
Title
Skin-Picking Disorder: A Guide to Diagnosis and Management
Authors
Mohammad Jafferany
Arsh Patel
Publication date
01-04-2019
Publisher
Springer International Publishing
Published in
CNS Drugs / Issue 4/2019
Print ISSN: 1172-7047
Electronic ISSN: 1179-1934
DOI
https://doi.org/10.1007/s40263-019-00621-7

Other articles of this Issue 4/2019

CNS Drugs 4/2019 Go to the issue