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American Journal of Clinical Dermatology
Published in: American Journal of Clinical Dermatology 2/2019

01-04-2019 | Leading Article

JAK Inhibitors for Atopic Dermatitis: An Update

Authors: Helen He, Emma Guttman-Yassky

Published in: American Journal of Clinical Dermatology | Issue 2/2019

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Abstract

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying degrees of Th1 and Th17 among various subtypes. The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) and spleen tyrosine kinase (SYK) pathways are involved in signaling of several AD-related cytokines, such as IFN-γ, IL-4, IL-13, IL-31, IL-33, IL-23, IL-22, and IL-17, mediating downstream inflammation and barrier alterations. While AD is primarily Th2-driven, the clinical and molecular heterogeneity of AD endotypes highlights the unmet need for effective therapeutic options that target more than one immune axis and are safe for long-term use. The JAK inhibitors, which target different combinations of kinases, have overlapping but distinct mechanisms of action and safety profiles. Several topical and oral JAK inhibitors have been shown to decrease AD severity and symptoms. A review of the JAK and SYK inhibitors that are currently undergoing evaluation for efficacy and safety in the treatment of AD summarizes available data on a promising area of therapeutics and further elucidates the complex molecular interactions that drive AD.
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Metadata
Title
JAK Inhibitors for Atopic Dermatitis: An Update
Authors
Helen He
Emma Guttman-Yassky
Publication date
01-04-2019
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 2/2019
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-018-0413-2

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