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Current Anesthesiology Reports
Published in: Current Anesthesiology Reports 4/2017

01-12-2017 | Geriatric Anesthesia (S Akhtar, Section Editor)

Neuronal Connectivity, General Anesthesia, and the Elderly

Author: Ramachandran Ramani

Published in: Current Anesthesiology Reports | Issue 4/2017

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Abstract

Purpose of Review

Due to change in demography, 33% of surgeries carried out are in geriatric patients, of which many develop POD and POCD with its major health care and public health consequences. This review will focus on functional connectivity in the brain, its pathophysiological changes with aging and anesthesia, and the consequent effects on brain function.

Recent Findings

Among the RSNs in the brain, DMN activity is significantly altered in in the aging brain and this correlates with the commonly observed mental function changes. Propofol and sevoflurane also affect DMN activity in young healthy subjects. While aging affects the anterior part of the DMN (frontal lobe regions), anesthesia affects activity in the posterior part (PCC, precuneus and, inferior parietal lobe).

Summary

Understanding the effect of surgery and anesthesia on connectivity in elderly is essential in order to be able to optimize brain function after surgery.
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Metadata
Title
Neuronal Connectivity, General Anesthesia, and the Elderly
Author
Ramachandran Ramani
Publication date
01-12-2017
Publisher
Springer US
Published in
Current Anesthesiology Reports / Issue 4/2017
Electronic ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-017-0241-6

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