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Acta Neurologica Belgica
Published in: Acta Neurologica Belgica 4/2018

01-12-2018 | Original Article

High angular resolution diffusion imaging correlates of depression in Parkinson’s disease: a connectometry study

Authors: Farzaneh Ghazi Sherbaf, Kaveh Same, Mohammad Hadi Aarabi

Published in: Acta Neurologica Belgica | Issue 4/2018

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Abstract

Depression is a significant disabling feature in Parkinson’s disease (PD). However, the neuropathology of this comorbidity is still unclear. In fact, few studies have tried to elucidate the neural correlates of depression in PD and have mostly examined specific regions of interest. In this study, we applied diffusion MRI connectometry, a powerful complementary approach to investigate alterations in whole white matter pathways regarding the severity of depressive symptoms. Using a multiple regression model, the correlation of severity of depressive symptoms assessed by the Hospital Anxiety and Depression Scale (HADS) with white matter connectivity was surveyed in 27 non-demented PD patients related to 26 age, sex, and educational level-matched healthy subjects. Results revealed areas, where white matter quantitative anisotropy (QA) was correlated with depression score in PD patients, without any significant association in healthy controls. The analysis showed a significant negative association (false discovery rate < 0.05) between scores on depression subscale of HADS in PD patients and QA of left Cingulum, Genu, and Splenium of the Corpus Callosum, and anterior and posterior limbs of the right internal capsule. This finding might improve our understanding of the neural basis of depression and its severity in PD.
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Metadata
Title
High angular resolution diffusion imaging correlates of depression in Parkinson’s disease: a connectometry study
Authors
Farzaneh Ghazi Sherbaf
Kaveh Same
Mohammad Hadi Aarabi
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 4/2018
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-018-0937-5

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