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Acta Neurologica Belgica
Published in: Acta Neurologica Belgica 2/2020

01-04-2020 | Letter to the Editor

Pyridoxine-induced sensory ataxic ganglionopathy: a case report and literature review

Authors: Elia Malek, Hassan Doumiati, Johnny S. Salameh

Published in: Acta Neurologica Belgica | Issue 2/2020

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Excerpt

Vitamin-B6, a water soluble vitamin, cannot be synthesized by mammals. They consume its inactive form as pyridoxine, pyridoxal and pyridoxamine. These are converted to pyridoxal phosphate (active ingredient) [1]. Pyridoxine is unsaturable and can be absorbed excessively [2]. Vitamin B6 is involved in the synthesis of neurotransmitters, thus affecting neuronal function [1]. …
Literature
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Said HM (2011) Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437:357–372CrossRef
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Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D et al (1983) Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 309(8):445–448CrossRef
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Dalton K, Dalton MJ (1987) Characteristics of pyridoxine overdose neuropathy syndrome. Acta Neurol Scand 76(1):8–11CrossRef
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Kulkantrakorn Kongkiat (2014) Pyridoxine-induced sensory ataxic neuronopathy and neuropathy: revisited. Neurol Sci 35:1827–1830CrossRef
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European Food Safety Authority (EFSA), Parma, Italy (2016) Draft scientific opinion. Scientific opinion on dietary reference values for vitamin B6. EFSA panel on dietetic products, nutrition and allergies (NDA). EFSA J 43:10–11
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Perry TA, Weerasuriya A, Mouton PR, Holloway HW, Greig NH (2004) Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol 190:133–144CrossRef
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Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM (2017) The vitamin B6 paradox: supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro 44:206–212CrossRef
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Potter MC, Wozniak KM, Callizot N, Slusher BS (2014) Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. PLoS One 9(9):e102936CrossRef
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Zhang W, Murakawa Y, Wozniak KM, Slusher B, Sima AA (2006) The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy. J Neurol Sci 247:217–223CrossRef
Metadata
Title
Pyridoxine-induced sensory ataxic ganglionopathy: a case report and literature review
Authors
Elia Malek
Hassan Doumiati
Johnny S. Salameh
Publication date
01-04-2020
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 2/2020
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-018-0919-7

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