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01-09-2018 | Original Article

Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series

Authors: Faruk Incecik, Ozlem M. Herguner, Seyda Besen, Mustafa Yılmaz

Published in: Acta Neurologica Belgica | Issue 3/2018

Abstract

Antibodies against glutamic acid decarboxylase (GAD) are associated with various neurologic conditions described in patients including stiff person syndrome, cerebellar ataxia, refractory epilepsy, limbic and extralimbic encephalitis. GAD antibodies-related limbic encephalitis cases are well described; reports of extralimbic involvement are limited. We describe four cases of GAD antibody-related autoimmune encephalitis. Three of them had extralimbic involvement and only one had limbic encephalitis.

Graus F, Saiz A, Dalmau J (2010) Antibodies and neuronal autoimmune disorders of the CNS. J Neurol 257:509–517CrossRefPubMed

Najjar S, Pearlman D, Najjar A, Ghiasian V, Zagzag D, Devinsky O (2011) Extralimbic autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: an underdiagnosed entity? Epilepsy Behav 21:306–313CrossRefPubMed

Malter MP, Helmstaedter C, Urbach H, Vincent A, Bien CG (2010) Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Ann Neurol 67:470–478CrossRefPubMed

Kobayakawa Y, Tateishi T, Kawamura N, Doii H, Ohyagi Y, Kira J (2010) A case of immune mediated encephalopathy showing refractory epilepsy and extensive brain MRI lesions associated with anti-glutamic acid decarboxylase antibody. Rinsho Sinkeigaku 50:92–97CrossRef

Kojima G, Inaba M, Bruno MK (2014) PET-positive extralimbic presentation of anti-glutamic acid decarboxylase antibody-associated encephalitis. Epileptic Disord 16:358–361PubMed

Saiz A, Blanco Y, Sabater L, González F, Bataller L, Casamitjana R, Ramió-Torrentà L, Graus F (2008) Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 131:2553–2563CrossRefPubMed

Pittock SJ, Yoshikawa HJ, Ahlskog E, Tisch SH, Benarroch EE, Kryzer TJ, Lennon VA (2006) Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction. Mayo Clin Proc 81:1207–1214CrossRefPubMed

Sloviter RS, Dichter MA, Rachinsky TL, Dean E, Goodman JH, Sollas AL, Martin DL (1996) Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus. J Comp Neurol 373:593–618CrossRefPubMed

Christgau S, Aanstoot HJ, Schierbeck H, Begley K, Tullin S, Hejnaes K, Baekkeskov S (1992) Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic betacells by palmitoylation in the NH2-terminal domain. J Cell Biol 118:309–320CrossRefPubMed

Title: Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series
Authors: Faruk Incecik
Ozlem M. Herguner
Seyda Besen
Mustafa Yılmaz
Publication date: 01-09-2018
Publisher: Springer International Publishing
Published in: Acta Neurologica Belgica / Issue 3/2018
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-018-0880-5

ACC 2024 Congress

Springer Medicine

Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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