Top

Published in:

01-06-2020 | Original Article

An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission

Authors: Halil Ay, Özlem Ethemoğlu

Published in: Acta Neurologica Belgica | Issue 3/2020

Abstract

The aim of this study was to investigate the effects of sodium valproate (SV) and carbamazepine (CBZ) on neuromuscular transmission using single-fibre electromyography (SFEMG) in patients with epilepsy. We performed SFEMG during the voluntary contraction of extensor digitorum communis muscle. 30 epileptic patients taking SV, 25 epileptic patients taking CBZ, and 25 age-matched healthy volunteers were included in the study. Mean jitter values (MCD) of subjects taking SV and CBZ were compared with normal controls. MCD values of subjects taking SV and CBZ were statistically significantly higher than those of control group. Review of the correlation between disease duration and MCD values of patients showed that MCD values were increased with the prolonged use of drugs, and thus, indicated a positive relationship between these two parameters. These results suggest that both SV and CBZ reduce neuromuscular transmission in patients without a neuromuscular junction disease.

Gilhus NE, Verschuuren JJ (2015) Myasthenia gravis: subgroup classification and therapeutic strategies. Lancet Neurol. 14(10):1023–1036CrossRef

Losavio A, Muchnik S (1997) Spontaneous acetylcholine release in mammalian neuromuscular junctions. Am J Physiol 273:1835–1841CrossRef

Flucher BE, Daniels MP (1989) Distribution of Na+ channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein. Neuron. 3:163–175CrossRef

Bora İ (2008) Epilepsi Nobel tıp kitap evi, birinci baskı 600

Perucca E (2002) Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs. 16(10):695–714CrossRef

Broicher T, Seidenbecher T, Meuth P, Munsch T, Meuth SG, Kanyshkova T, Pape HC, Budde T (2007) T-current related effects of antiepileptic drugs and a Ca²⁺ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy. Neuropharmacology 53:431–446CrossRef

VanDongen AM, VanErp MG, Voskuyl RA (1986) Valproate reduces excitability by blockage of sodium and potassium conductance. Epilepsia. 27:177–182CrossRef

Spiller HA, Carlisle RD (2002) Status epilepticus after massive carbamazepine overdose. J Toxicol Clin Toxicol 40:81–90CrossRef

Perucca E (2001) Clinical pharmacology and therapeutic use of the new antiepileptic drugs. Fundam Clin Pharmacol 15:405–417CrossRef

10.

Cherian Ajith, Baheti Neeraj N, Iype Thomas (2013) Electrophysiological study in neuromuscular junction disorders. Ann Indian Acad Neurol 16(1):34–41CrossRef

11.

Stalberg E, Sanders DB, Ali S, Cooray G, Leonardis L, Löseth S, Machado F, Maldonado A, Martinez-Aparicio C, Sandberg A, Smith B, Widenfalk J, Aris Kouyoumdjian J (2016) Reference values for jitter recorded by concentric needle electrodes in healthy controls: a multicenter study. Muscle Nerve 53(3):351–362CrossRef

12.

Boneva N, Brenner T, Argov Z (2000) Gabapentin may be hazardous in myasthenia gravis. Muscle Nerve 23:1204–1208CrossRef

13.

So EL, Penry JK (1981) Adverse effects of phenytoin on peripheral nerves and neuromuscular junction: a review. Epilepsia 22:467–473CrossRef

14.

Kurian MA, King MD (2003) Antibody positive myasthenia gravis following treatment with carbamazepine—a chance association? Neuropediatrics 34:276–277CrossRef

15.

Rasmussen M (2004) Carbamazepine and myasthenia gravis. Neuropediatrics 35:259CrossRef

16.

Losavio A, Muchnik S (1997) Spontaneous acetylcholine release in mammalian neuromuscular junctions. Am J Physiol 273:1835–1841CrossRef

17.

Alderdice MT, Trommer BA (1980) Differential effects of the anticonvulsants phenobarbital, ethosuximide and carbamazepine on neuromuscular transmission. J Pharmacol Exp Ther 215(1):92–96PubMed

18.

Ozkul Y (2007) Influence of calcium channel blocker drugs in neuromuscular transmission. Clin Neurophysiol 118:2005–2008CrossRef

19.

Ambrosini A, Pierelli F, Schoenen J (2003) Acetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs. Cephalalgia 23(2):75–78CrossRef

20.

Murga L, Sanchez F, Menendez C, Castilla JM (1998) Diagnostic yield of stimulation and voluntary single fiber electromyography in myasthenia gravis. Muscle Nerve 21:1081–1083CrossRef

21.

Farrugia ME, Weir AI, Cleary M, Cooper S, Metcalfe R, Mallik A (2009) Concentric and single fiber needle electrodes yield comparable jitter results in myasthenia gravis. Muscle Nerve 39:579–585CrossRef

22.

Ertaş M, Baslo MB, Yildiz N, Yazici J, Oge AE (2000) Concentric needle electrode for neuromuscular jitter analysis. Muscle Nerve 23:715–771CrossRef

23.

Patten BM (1978) Myasthenia gravis: review of diagnosis and management. Muscle Nerve 1:190–205CrossRef

24.

Rodriguez M, Gomez MR, Howard FM Jr, Taylor WF (1983) Myasthenia gravis in children. Ann Neurol 13:504–510CrossRef

25.

Tartara A, Mola M, Manni R et al (1982) EEG findings in 118 cases of myasthenia gravis. Rev Electroencephalogr Neurophysiol Clin. 12:275–279CrossRef

Title: An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission
Authors: Halil Ay
Özlem Ethemoğlu
Publication date: 01-06-2020
Publisher: Springer International Publishing
Published in: Acta Neurologica Belgica / Issue 3/2020
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-017-0839-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2020

Intrathecal gadolinium-enhanced MR-cisternography for the detection of a petrous bone defect in a patient with spontaneous intraventricular pneumocephalus

Autoimmune encephalitis and immune therapy: lessons from Argentina

Eotaxins and C–C chemokine receptor type 3 in Parkinson’s disease

Correlation of proximal and distal muscle strength with upper limb functional ability in patients with essential tremor

Role of endoscopic surgical biopsy in diagnoses of intraventricular/periventricular tumors: review of literature including a monocentric case series

Simulating glioblastoma growth consisting both visible and invisible parts of the tumor using a diffusion–reaction model followed by resection and radiotherapy