Skip to main content
Top
Published in: Acta Neurologica Belgica 1/2017

01-03-2017 | Original Article

Pupil cycle time: as indicator of visual pathway dysfunction in multiple sclerosis

Authors: Eyyup Karahan, Omer Karti, Aslı Koskderelioglu, Dilek Top Karti, Murat Uyar, Murat Yildirim Kale, Muhtesem Gedizlioglu

Published in: Acta Neurologica Belgica | Issue 1/2017

Login to get access

Abstract

To evaluate the value of pupil cycle time (PCT) as an indicator of optic nerve dysfunction in patients with multiple sclerosis (MS), 42 patients with MS and 35 control subjects were included to the study. Patients with MS with a history of ON were accepted as group 1, without a history of ON as group 2 and healthy control subjects as group 3. Groups were compared with Chi-square and one-way ANOVA tests. Correlations of PCT results with age, best corrected visual acuity, duration of MS, visual field (VF) test, visual evoked potential (VEP) latans, retinal nerve fiber layer (RNFL), and ganglion cell layer–inner plexiform layer (GCL–IPL) thicknesses were analyzed. Mean PCT was 1286.4 ± 357.8 ms in group 1, 1021.3 ± 102.3 ms in group 2, and 872.5 ± 69.4 ms in group 3 (p < 0.001). Moderate-to-significant correlations were found between PCT measurements and duration of MS, VF test, VEP latans, RNFL, and GCL–IPL thicknesses. PCT might be an alternative method to evaluate the optic nerve function in patients with MS.
Literature
1.
go back to reference Mizota A, Niimura M, Adachi-Usami E (2004) Clinical characteristics of Japanese children with optic neuritis. Pediatr Neurol 31(1):42–45CrossRefPubMed Mizota A, Niimura M, Adachi-Usami E (2004) Clinical characteristics of Japanese children with optic neuritis. Pediatr Neurol 31(1):42–45CrossRefPubMed
2.
go back to reference Shiraishi K, Higuchi Y, Ozawa K, Hao Q, Saida T (2005) Clinical course and prognosis of 27 patients with childhood onset multiple sclerosis in Japan. Brain Dev 27(3):224–227CrossRefPubMed Shiraishi K, Higuchi Y, Ozawa K, Hao Q, Saida T (2005) Clinical course and prognosis of 27 patients with childhood onset multiple sclerosis in Japan. Brain Dev 27(3):224–227CrossRefPubMed
3.
go back to reference Arnold AC (2005) Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 139(6):1101–1108CrossRefPubMed Arnold AC (2005) Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 139(6):1101–1108CrossRefPubMed
4.
go back to reference Sakai RE, Feller DJ, Galletta KM, Galetta SL, Balcer LJ (2011) Vision in multiple sclerosis (MS): the story, structure–function correlations, and models for neuroprotection. J Neuroophtalmol 31(4):362–373CrossRef Sakai RE, Feller DJ, Galletta KM, Galetta SL, Balcer LJ (2011) Vision in multiple sclerosis (MS): the story, structure–function correlations, and models for neuroprotection. J Neuroophtalmol 31(4):362–373CrossRef
5.
go back to reference Fisher JB, Jacobs DA, Markowitz CE, Galetta SL, Volpe NJ, Nano-Schiavi ML, Baier ML, Frohman EM, Winslow H, Frohman TC, Calabresi PA, Maguire MG, Cutter GR, Balcer LJ (2006) Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophtalmology 113(2):324–332CrossRef Fisher JB, Jacobs DA, Markowitz CE, Galetta SL, Volpe NJ, Nano-Schiavi ML, Baier ML, Frohman EM, Winslow H, Frohman TC, Calabresi PA, Maguire MG, Cutter GR, Balcer LJ (2006) Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophtalmology 113(2):324–332CrossRef
6.
go back to reference Pulicken M, Gordon-Lipkin E, Balcer LJ, Frohman E, Cutter G, Calabresi PA (2007) Optical coherence tomography and disease subtype in multiple sclerosis. Neurology 69(22):2085–2092CrossRefPubMed Pulicken M, Gordon-Lipkin E, Balcer LJ, Frohman E, Cutter G, Calabresi PA (2007) Optical coherence tomography and disease subtype in multiple sclerosis. Neurology 69(22):2085–2092CrossRefPubMed
8.
9.
go back to reference Link H, Huang YM (2006) Oligoclonal bands in multiple sclerosis cerebro–spinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol 180(1–2):17–28CrossRefPubMed Link H, Huang YM (2006) Oligoclonal bands in multiple sclerosis cerebro–spinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol 180(1–2):17–28CrossRefPubMed
10.
go back to reference Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444–1452CrossRefPubMed Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444–1452CrossRefPubMed
11.
go back to reference Khanifar AA, Parlitsis GJ, Erlich JR, Aaker GD, D’Amico DJ, Gauthier SA, Kiss S (2010) Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography. Clinic Ophtalmol 20(4):1007–1013 Khanifar AA, Parlitsis GJ, Erlich JR, Aaker GD, D’Amico DJ, Gauthier SA, Kiss S (2010) Retinal nerve fiber layer evaluation in multiple sclerosis with spectral domain optical coherence tomography. Clinic Ophtalmol 20(4):1007–1013
12.
go back to reference Costello F, Hodge W, Yi Pan, Metz L, Kardon RH (2008) Retinal nerve fiber layer and future risk of multiple sclerosis. Can J Neurol Sci 35(4):482–487CrossRefPubMed Costello F, Hodge W, Yi Pan, Metz L, Kardon RH (2008) Retinal nerve fiber layer and future risk of multiple sclerosis. Can J Neurol Sci 35(4):482–487CrossRefPubMed
13.
go back to reference Parisi V, Manni G, Spadaro M, Colacino G, Restuccia R, Marchi S, Bucci MG, Pierelli F (1999) Correlations between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophtalmol Vis Sci 40:2520–2527 Parisi V, Manni G, Spadaro M, Colacino G, Restuccia R, Marchi S, Bucci MG, Pierelli F (1999) Correlations between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophtalmol Vis Sci 40:2520–2527
14.
go back to reference Naismith RT, Tutlam NT, Xu J, Shepherd JB, Klawiter EC, Song SK, Cross AH (2009) Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis. Neurology 73(1):46–52CrossRefPubMedPubMedCentral Naismith RT, Tutlam NT, Xu J, Shepherd JB, Klawiter EC, Song SK, Cross AH (2009) Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis. Neurology 73(1):46–52CrossRefPubMedPubMedCentral
15.
go back to reference Costello F, Coupland S, Hodge W, Lorello GR, Koroluk J, Pan YI, Freedman MS, Zackon DH, Kardon RH (2006) Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 59(6):963–969CrossRefPubMed Costello F, Coupland S, Hodge W, Lorello GR, Koroluk J, Pan YI, Freedman MS, Zackon DH, Kardon RH (2006) Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 59(6):963–969CrossRefPubMed
16.
go back to reference Gallo A, Esposito F, Sacco R, Docimo R, Bisecco A, Della Corte M, D’Ambrosio A, Corbo D, Rosa N, Lanza M, Cirillo S, Bonavita S, Tedeschi G (2012) Visual resting-state network in relapsing–remitting MS with and without previous optic neuritis. Neurology 79(14):1458–1465CrossRefPubMed Gallo A, Esposito F, Sacco R, Docimo R, Bisecco A, Della Corte M, D’Ambrosio A, Corbo D, Rosa N, Lanza M, Cirillo S, Bonavita S, Tedeschi G (2012) Visual resting-state network in relapsing–remitting MS with and without previous optic neuritis. Neurology 79(14):1458–1465CrossRefPubMed
17.
go back to reference Klistorner A, Garrick R, Barnett MH, Graham SL, Arvind H, Sriram P, Yiannikas C (2013) Axonal loss in non-optic neuritis eyes of patients with multiple sclerosis linked to delayed visual evoked potential. Neurology 80(3):242–245CrossRefPubMed Klistorner A, Garrick R, Barnett MH, Graham SL, Arvind H, Sriram P, Yiannikas C (2013) Axonal loss in non-optic neuritis eyes of patients with multiple sclerosis linked to delayed visual evoked potential. Neurology 80(3):242–245CrossRefPubMed
18.
go back to reference Sriram P, Wang C, Yiannikas C, Garrick R, Barnett M, Parratt J, Graham SL, Arvind H, Klistorner A (2014) Relationship between optical coherence tomography and electrophysiology of the visual pathway in non-optic neuritis eyes of multiple sclerosis patients. PLoS One 9:e102546CrossRefPubMedPubMedCentral Sriram P, Wang C, Yiannikas C, Garrick R, Barnett M, Parratt J, Graham SL, Arvind H, Klistorner A (2014) Relationship between optical coherence tomography and electrophysiology of the visual pathway in non-optic neuritis eyes of multiple sclerosis patients. PLoS One 9:e102546CrossRefPubMedPubMedCentral
19.
go back to reference Oberwahrenbrock T, Ringelstein M, Jentschke S, Deuschle K, Klumbies K, Bellmann-Strobl J, Harmel J, Ruprecht K, Schippling S, Hartung HP, Aktas O, Brandt AU, Paul F (2013) Retinal ganglion cell and inner plexi-form layer thinning in clinically isolated syndrome. Mult Scler 19(14):1887–1895CrossRefPubMed Oberwahrenbrock T, Ringelstein M, Jentschke S, Deuschle K, Klumbies K, Bellmann-Strobl J, Harmel J, Ruprecht K, Schippling S, Hartung HP, Aktas O, Brandt AU, Paul F (2013) Retinal ganglion cell and inner plexi-form layer thinning in clinically isolated syndrome. Mult Scler 19(14):1887–1895CrossRefPubMed
20.
go back to reference Oberwahrenbrock T, Schippling S, Ringelstein M, Kaufhold F, Zimmermann H, Keser N, Young KL, Harmel J, Hartung HP, Martin R, Paul F, Aktas O, Brandt AU (2012) Retinal damage in multiple sclerosis disease subtypes measured by high resolution optical coherence tomography. Mult Scler Int 2012:530305PubMedPubMedCentral Oberwahrenbrock T, Schippling S, Ringelstein M, Kaufhold F, Zimmermann H, Keser N, Young KL, Harmel J, Hartung HP, Martin R, Paul F, Aktas O, Brandt AU (2012) Retinal damage in multiple sclerosis disease subtypes measured by high resolution optical coherence tomography. Mult Scler Int 2012:530305PubMedPubMedCentral
21.
go back to reference Ratchford JN, Saidha S, Sotirchos ES, Oh JA, Seigo MA, Eckstein C, Durbin MK, Oakley JD, Meyer SA, Conger A, Frohman TC, Newsome SD, Balcer LJ, Frohman EM, Calabresi PA (2013) Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning. Neurology 80(1):47–54CrossRefPubMedPubMedCentral Ratchford JN, Saidha S, Sotirchos ES, Oh JA, Seigo MA, Eckstein C, Durbin MK, Oakley JD, Meyer SA, Conger A, Frohman TC, Newsome SD, Balcer LJ, Frohman EM, Calabresi PA (2013) Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning. Neurology 80(1):47–54CrossRefPubMedPubMedCentral
Metadata
Title
Pupil cycle time: as indicator of visual pathway dysfunction in multiple sclerosis
Authors
Eyyup Karahan
Omer Karti
Aslı Koskderelioglu
Dilek Top Karti
Murat Uyar
Murat Yildirim Kale
Muhtesem Gedizlioglu
Publication date
01-03-2017
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 1/2017
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-016-0740-0

Other articles of this Issue 1/2017

Acta Neurologica Belgica 1/2017 Go to the issue