Top

Published in:

01-03-2016 | Original Article

Serostatus of Epstein–Barr virus in Iranian MS patients

Authors: Sajad Karampoor, Hamid Zahednasab, Angila Ataei Pirkouh, Seyed Hamid Reza Monavari, Sreeram Ramagopalan, Hossein Keyvani

Published in: Acta Neurologica Belgica | Issue 1/2016

Abstract

Multiple sclerosis (MS) is a common, complex disorder. Associations of MS with Epstein–Barr virus (EBV) infection in Caucasian populations are well documented. However, in the Iranian population, previous studies have been conflicting. Sixty patients with MS and 50 healthy controls were tested for anti-EBV antibodies using chemiluminescent assays. All MS patients to be seropositive for EBV as compared to 82 % of controls (p = 0.0006). A strong, significant association of MS with EBV infection was documented, similar to studies in first world populations. Future studies should investigate the temporal sequence of infection to try to understand the cause of the recent increase in MS risk in Iran.

Ramagopalan SV, Dobson R, Meier UC, Giovannoni G (2010) Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol 9(7):727–739CrossRefPubMed

Etemadifar M, Abtahi S-H, Akbari M, Murray RT, Ramagopalan SV, Fereidan-Esfahani M (2013) Multiple sclerosis in Isfahan, Iran: an update. Mult Scler Houndmills Basingstoke Engl 20(8):1145–1147CrossRef

Khaki M, Ghazavi A, Ghasami K, Rafiei M, Payani M-A, Ghaznavi-Rad E et al (2011) Evaluation of viral antibodies in Iranian multiple sclerosis patients. Neurosci Riyadh Saudi Arab 16(3):224–228

McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International panel on the diagnosis of multiple sclerosis. Ann Neurol 50(1):121–127CrossRefPubMed

Polman CH, Reingold SC, Edan G, Filippi M, Hartung H-P, Kappos L et al (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the ‘McDonald Criteria’. Ann Neurol 58(6):840–846CrossRefPubMed

Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11):1444–1452CrossRefPubMed

Levin LI, Munger KL, O’Reilly EJ, Falk KI, Ascherio A (2010) Primary infection with the Epstein–Barr virus and risk of multiple sclerosis. Ann Neurol 67(6):824–830PubMedCentralPubMed

Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D et al (2005) Temporal relationship between elevation of Epstein–Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA 293(20):2496–2500CrossRefPubMed

Ramroodi N, Niazi AA, Sanadgol N, Ganjali Z, Sarabandi V (2013) Evaluation of reactive Epstein–Barr Virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS). Braz J Infect Dis Off Publ Braz Soc Infect Dis 17(2):156–163

10.

De Paschale M, Clerici P (2012) Serological diagnosis of Epstein–Barr virus infection: problems and solutions. World J Virol 1(1):31–43PubMedCentralCrossRefPubMed

11.

Farrell RA, Antony D, Wall GR, Clark DA, Fisniku L, Swanton J et al (2009) Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 73(1):32–38PubMedCentralCrossRefPubMed

12.

Etemadifar M, Izadi S, Nikseresht A, Sharifian M, Sahraian MA, Nasr Z (2014) Estimated prevalence and incidence of multiple sclerosis in Iran. Eur Neurol 72(5–6):370–374CrossRefPubMed

Title: Serostatus of Epstein–Barr virus in Iranian MS patients
Authors: Sajad Karampoor
Hamid Zahednasab
Angila Ataei Pirkouh
Seyed Hamid Reza Monavari
Sreeram Ramagopalan
Hossein Keyvani
Publication date: 01-03-2016
Publisher: Springer Milan
Published in: Acta Neurologica Belgica / Issue 1/2016
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-015-0496-y

At a glance: The STEP trials

Springer Medicine

Serostatus of Epstein–Barr virus in Iranian MS patients

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2016

Clinical analysis of hemifacial spasm patients with delay symptom relief after microvascular decompression of distinct offending vessels

A rare combination: Sturge–Weber syndrome and accompanying Dyke–Davidoff–Masson syndrome

Comment on: Hemidystonia caused by frontal cortical infarction

Erratum to: Mechanical endovascular thrombectomy for acute ischemic stroke: a retrospective multicenter study in Belgium

Nervous system Lyme disease, chronic Lyme disease, and none of the above

Low vitamin D levels in healthy controls and patients with autoimmune neuromuscular disorders in Greece