Top

Published in:

01-03-2015 | Original Article

Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey

Authors: Asuman Celikbilek, Ayse Yesim Gocmen, Nermin Tanik, Elif Borekci, Mehmet Adam, Mehmet Celikbilek, Murat Suher, Namik Delibas

Published in: Acta Neurologica Belgica | Issue 1/2015

Abstract

Data examining the association between vitamin D and diabetic peripheral neuropathy are limited. This study investigated the serum levels of vitamin D, vitamin D-binding protein (VDBP), and vitamin D receptor (VDR) in diabetics in the Yozgat region of Turkey, and assessed their relationships with diabetic peripheral neuropathy. 69 diabetic patients and 49 age- and sex-matched control subjects were enrolled in this clinical prospective study. All the diabetics underwent conventional sensory and motor nerve conduction studies, and diabetic peripheral neuropathy was confirmed or ruled out according to the electromyography findings and Douleur Neuropathique 4 questions. Serum vitamin D, VDBP and VDR levels were measured using commercial enzyme-linked immunosorbent assay kits. The serum vitamin D levels (p = 0.001) were significantly lower, while the VDR levels (p = 0.003) were higher, in diabetics than in controls. The serum VDBP levels were similar in both groups (p > 0.05). The serum vitamin D levels were significantly lower in diabetics with diabetic peripheral neuropathy than in those without (p = 0.032), whereas the serum VDBP and VDR levels were similar in these two groups (p > 0.05). The lower serum vitamin D levels in diabetics, especially in those with peripheral neuropathy, may suggest a neurotrophic effect of vitamin D.

Holick MF (2007) Vitamin D deficiency. New Engl J Med 357(3):266–281. doi:10.1056/NEJMra070553 CrossRefPubMed

Makariou S, Liberopoulos EN, Elisaf M, Challa A (2011) Novel roles of vitamin D in disease: what is new in 2011? Eur J Intern Med 22(4):355–362. doi:10.1016/j.ejim.2011.04.012 CrossRefPubMed

Pierrot-Deseilligny C (2009) Clinical implications of a possible role of vitamin D in multiple sclerosis. J Neurol 256(9):1468–1479. doi:10.1007/s00415-009-5139-x CrossRefPubMedCentralPubMed

Smolders J, Thewissen M, Peelen E, Menheere P, Tervaert JW, Damoiseaux J, Hupperts R (2009) Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One 4(8):e6635. doi:10.1371/journal.pone.0006635 CrossRefPubMedCentralPubMed

Zipitis CS, Akobeng AK (2008) Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child 93(6):512–517. doi:10.1136/adc.2007.128579 CrossRefPubMed

The NS, Crandell JL, Lawrence JM, King IB, Dabelea D, Marcovina SM, D’Agostino RB Jr, Norris JM, Pihoker C, Mayer-Davis EJ (2013) Vitamin D in youth with type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study. Diabet Med 30(11):1324–1332. doi:10.1111/dme.12297 CrossRefPubMed

Tohidi M, Bozorgmanesh M, Mohebi R, Khalili D, Saadat N, Khorrami N, Azizi F, Hadaegh F (2013) Non-linear association between 25-hydroxyvitamin D and the incidence of type 2 diabetes: a community-based nested case-control study. Diabetic Med 30(8):934–938. doi:10.1111/Dme.12180 CrossRefPubMed

Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92(6):2017–2029. doi:10.1210/jc.2007-0298 CrossRefPubMedCentralPubMed

Argoff CE, Cole BE, Fishbain DA, Irving GA (2006) Diabetic peripheral neuropathic pain: clinical and quality-of-life issues. Mayo Clin Proc 81(4 Suppl):S3–S11CrossRefPubMed

10.

Girach A, Manner D, Porta M (2006) Diabetic microvascular complications: can patients at risk be identified? A review. Int J Clin Pract 60(11):1471–1483. doi:10.1111/j.1742-1241.2006.01175.x CrossRefPubMed

11.

Bell DS (2012) Reversal of the symptoms of diabetic neuropathy through correction of vitamin D deficiency in a type 1 diabetic patient. Case Rep Endocrinol 2012:165056. doi:10.1155/2012/165056 PubMedCentralPubMed

12.

Soderstrom LH, Johnson SP, Diaz VA, Mainous AG (2012) Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001–2004 NHANES. Diabet Med 29(1):50–55. doi:10.1111/j.1464-5491.2011.03379.x CrossRefPubMedCentralPubMed

13.

Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA (2012) Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes? Diabet Med 29(1):43–49. doi:10.1111/j.1464-5491.2011.03510.x CrossRefPubMed

14.

Skalli S, Muller M, Pradines S, Halimi S, Wion-Barbot N (2012) Vitamin D deficiency and peripheral diabetic neuropathy. Eur J Intern Med 23(2):e67–e68. doi:10.1016/j.ejim.2011.11.008 CrossRefPubMed

15.

Lee P, Chen R (2008) Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med 168(7):771–772. doi:10.1001/archinte.168.7.771 CrossRefPubMed

16.

Rhee SY, Hwang YC, Chung HY, Woo JT (2012) Vitamin D and diabetes in Koreans: analyses based on the Fourth Korea National Health and Nutrition Examination Survey (KNHANES), 2008–2009. Diabet Med 29(8):1003–1010. doi:10.1111/j.1464-5491.2012.03575.x CrossRefPubMedCentralPubMed

17.

American Diabetes A (2009) Diagnosis and classification of diabetes mellitus. Diabetes Care 32(Suppl 1):S62–S67. doi:10.2337/dc09-S062 CrossRef

18.

Singleton JR, Smith AG, Bromberg MB (2001) Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy. Diabetes Care 24(8):1448–1453CrossRefPubMed

19.

Prakash S, Mehta NC, Dabhi AS, Lakhani O, Khilari M, Shah ND (2010) The prevalence of headache may be related with the latitude: a possible role of vitamin D insufficiency? J Headache Pain 11(4):301–307. doi:10.1007/s10194-010-0223-2 CrossRefPubMedCentralPubMed

20.

Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B, Bruxelle J, Cunin G, Fermanian J, Ginies P, Grun-Overdyking A, Jafari-Schluep H, Lanteri-Minet M, Laurent B, Mick G, Serrie A, Valade D, Vicaut E (2005) Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 114(1–2):29–36. doi:10.1016/j.pain.2004.12.010 CrossRefPubMed

21.

Chandy A, Pawar B, John M, Isaac R (2008) Association between diabetic nephropathy and other diabetic microvascular and macrovascular complications. Saudi J Kidney Dis Transpl 19(6):924–928PubMed

22.

Petrone AB, Weir NL, Steffen BT, Tsai MY, Gaziano JM, Djousse L (2013) Plasma vitamin D-binding protein and risk of heart failure in male physicians. Am J Cardiol 112(6):827–830. doi:10.1016/j.amjcard.2013.05.014 CrossRefPubMedCentralPubMed

23.

Boucher BJ (2011) Vitamin D insufficiency and diabetes risks. Curr Drug Targets 12(1):61–87CrossRefPubMed

24.

George PS, Pearson ER, Witham MD (2012) Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med 29(8):e142–e150. doi:10.1111/j.1464-5491.2012.03672.x CrossRefPubMed

25.

Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, Vigo A, Hoogeveen R, Folsom AR, Heiss G, Atherosclerosis Risk in Communities S (2003) Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52(7):1799–1805CrossRefPubMed

26.

Hewison M (2010) Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 39(2):365–379. doi:10.1016/j.ecl.2010.02.010 table of contentsCrossRefPubMedCentralPubMed

27.

Danescu LG, Levy S, Levy J (2009) Vitamin D and diabetes mellitus. Endocrine 35(1):11–17. doi:10.1007/s12020-008-9115-5 CrossRefPubMed

28.

Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R (2003) The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 57(4):258–261PubMed

29.

Palomer X, Gonzalez-Clemente JM, Blanco-Vaca F, Mauricio D (2008) Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab 10(3):185–197. doi:10.1111/j.1463-1326.2007.00710.x CrossRefPubMed

30.

Riaz S, Malcangio M, Miller M, Tomlinson DR (1999) A vitamin D (3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats. Diabetologia 42(11):1308–1313. doi:10.1007/s001250051443 CrossRefPubMed

31.

Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D (2002) New clues about vitamin D functions in the nervous system. Trends Endocrin Met 13(3):100–105. doi:10.1016/S1043-2760(01)00547-1 CrossRef

32.

Plotnikoff GA, Quigley JM (2003) Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 78(12):1463–1470. doi:10.4065/78.12.1463 CrossRefPubMed

33.

Valensi P, Le Devehat C, Richard JL, Farez C, Khodabandehlou T, Rosenbloom RA, LeFante C (2005) A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complicat 19(5):247–253. doi:10.1016/j.jdiacomp.2005.05.011 CrossRefPubMed

34.

Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C (2002) A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol 9(2):131–136. doi:10.1038/nsb754 CrossRefPubMed

35.

White P, Cooke N (2000) The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab 11(8):320–327CrossRefPubMed

36.

Nyomba BL, Bouillon R, Lissens W, Vanbaelen H, Demoor P (1985) 1,25-Dihydroxyvitamin-D and vitamin D-binding Protein are both decreased in streptozotocin-diabetic rats. Endocrinology 116(6):2483–2488CrossRefPubMed

37.

Chiu KC, Chu A, Go VLW, Saad MF (2004) Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 79(5):820–825PubMed

38.

Chuang JC, Cha JY, Garmey JC, Mirmira RG, Repa JJ (2008) Research resource: nuclear hormone receptor expression in the endocrine pancreas. Mol Endocrinol 22(10):2353–2363. doi:10.1210/me.2007-0568 CrossRefPubMedCentralPubMed

39.

Choi M, Ozeki J, Hashizume M, Kato S, Ishihara H, Makishima M (2012) Vitamin D receptor activation induces peptide YY transcription in pancreatic islets. Endocrinology 153(11):5188–5199. doi:10.1210/en.2012-1396 CrossRefPubMed

40.

Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, Hewison M (2004) Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 89–90(1–5):121–125. doi:10.1016/j.jsbmb.2004.03.115 CrossRefPubMed

41.

Ordonez-Moran P, Munoz A (2009) Nuclear receptors: genomic and non-genomic effects converge. Cell Cycle 8(11):1675–1680CrossRefPubMed

Title: Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey
Authors: Asuman Celikbilek
Ayse Yesim Gocmen
Nermin Tanik
Elif Borekci
Mehmet Adam
Mehmet Celikbilek
Murat Suher
Namik Delibas
Publication date: 01-03-2015
Publisher: Springer Milan
Published in: Acta Neurologica Belgica / Issue 1/2015
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-014-0304-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2015

Painful legs and moving toes syndrome: responsive to dopaminergic treatment

Choroidal thickness changes in patients with migraine

Could coenzyme Q10 supplementation have a role in the treatment of anti-NMDA receptor encephalitis?

Uncommon and/or bizarre features of dementia

Dural puncture: an overlooked cause of cerebral venous thrombosis

Early onset degenerative dementias: demographic characteristics and etiologic classification in a tertiary referral center