Top

Published in:

01-03-2012 | Case Report

Topiramate-induced acute myopia with MRI contrast enhancement

Authors: Manuel Facundo Latini, Lucas Martín Romano

Published in: Acta Neurologica Belgica | Issue 1/2012

Abstract

Topiramate is a sulfamate-substituted monosaccharide mainly used to treat epilepsy in children and adults and prophylaxis of migraine. This article describes a case of topiramate-induced acute transient myopia. The underlying mechanism and management is discussed. A 13-year-old female complained of sudden onset of blurred vision; 7 days prior to this she had commenced topiramate therapy for migraine prophylaxis. Visual acuity was reduced in both eyes. Examination revealed myopic refractive changes which resolved quickly following discontinuation of the drug. An MRI showed uveoscleral and subcutaneous cellular tissue abnormalities in the T1 contrasted images.

Ferraro D, Di Trapani G (2008) Topiramate in the prevention of pediatric migraine: literature review. J Headache Pain 9:147–150PubMedCrossRef

NDA 20–505/S-002, NDA 20–844/S-010. Approved labeling text dated 08/28/01. Available at: www.accessdata.fda.gov/drugsatfda_docs/label/2001/20505S002lbl.pdf. (Accessed: February 11, 2011)

Hulihan J. Important drug warning. Ortho-McNeil Pharmaceutical, Inc. Avaiable at: http://www.fda.gov/downloads/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/UCM173936.pdf. (Accessed: February 11, 2011)

Cereza G, Pedrós C, Garcia N, Laporte JR (2005) Topiramate in non-approved indications and acute myopia or angle closure glaucoma. Br J Clin Pharmacol 60(5):578–579PubMedCrossRef

Rodríguez-Gómez D, Castro-Pérez A, Landaluce-Chaves ML, Cid-Rodríguez MC, Lustres-Pérez M, Gómez-Fernández RC (2007) Narrow-angle glaucoma and acute myopia from using topiramate as prophylactic treatment of migraine. Rev Neurol 45(4):254PubMed

Natesh S, Rajashekhara SK, Rao AS, Shetty B (2010) Topiramate-induced angle closure with acute myopia, macular striae. Oman J Ophthalmol 3(1):26–28PubMedCrossRef

Craig JE, Ong TJ, Louis DL, Wells JM (2004) Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma. Am J Ophthalmol 137(1):193–195PubMedCrossRef

Ikeda N, Ikeda T, Nagata M, Mimura O (2002) Ciliochoroidal effusion syndrome induced by sulfa derivatives. Arch Ophthalmol 120(12):1775PubMed

Boentert M, Aretz H, Ludemann P (2003) Acute myopia and angle-closure glaucoma induced by topiramate. Neurology 61(9):1306PubMed

10.

Gawley SD (2009) Topiramate induced acute transient myopia: a case report. Cases J 2:7430PubMedCrossRef

11.

Spaccapelo L, Leschiutta S, Aurea C, Ferrari A (2009) Topiramate-associated acute glaucoma in a migraine patient receiving concomitant citalopram therapy: a case-report. Cases J 2(1):87PubMedCrossRef

12.

Desai CM, Ramchandani SJ, Bhopale SG, Ramchandani SS (2006) Acute myopia and angle closure caused by topiramate, a drug used for prophylaxis of migraine. Indian J Ophthalmol 54(3):195–197PubMedCrossRef

13.

Viet Tran H, Ravinet E, Schnyder C, Reichhart M, Guex-Crosier Y (2006) Blood-brain barrier disruption associated with topiramate-induced angle-closure glaucoma of acute onset. Klin Monbl Augenheilkd. 223(5):425–427PubMedCrossRef

Title: Topiramate-induced acute myopia with MRI contrast enhancement
Authors: Manuel Facundo Latini
Lucas Martín Romano
Publication date: 01-03-2012
Publisher: Springer Milan
Published in: Acta Neurologica Belgica / Issue 1/2012
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-012-0022-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Topiramate-induced acute myopia with MRI contrast enhancement

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2012

Giant cell ependymoma of the thoracic spinal cord

Phenotypic heterogeneity in hereditary motor neuropathy type V: a new case report series

Subperiostal orbital hematomas as an unusual complication of liver cirrhosis

Efficacy and safety of cinnarizine in the prophylaxis of migraine headaches in children: an open, randomized comparative trial with propranolol

Diffusion restriction in the splenium of the corpus callosum in a patient with the syndrome of transient headache with neurological deficits and CSF lymphocytosis (HaNDL): a challenge to the diagnostic criteria?

Disproportionately large communicating fourth ventricle resulting from adjustable valve shunt in an infant