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Published in:

01-03-2012 | Original Article

Association of inflammatory biomarkers with sleep disorders in hemodialysis patients

Authors: Effat Razeghi, Mohammad Ali Sahraian, Rouhollah Heidari, Mohammad Bagherzadeh

Published in: Acta Neurologica Belgica | Issue 1/2012

Abstract

The aim of this study was to investigate the relationship between sleep disorders and C-reactive protein (CRP), hallmark of inflammation, and other biomarkers which may alter in hemodialysis patients. Our study included 108 patients who were dialyzed at least for 3 months. Before hemodialysis, blood samples were collected and serum levels of CRP, ferritin, albumin, phosphorus, parathyroid hormone, and hemoglobin were measured. Sleep disorders were confirmed by the presence of at least one of following criteria: insomnia, restless leg syndrome (RLS), obstructive sleep apnea syndrome (OSAS), narcolepsy, nightmare, sleepwalking, and poor sleep. 82.4% of patients demonstrated sleep disorders; insomnia (50%), RLS (32.4%), OSAS (7.4%), narcolepsy (15.7%), nightmare (15.7%), sleepwalking (0.9%), and poor sleep (71.3%). Our results revealed that CRP ≥3.8 μg/ml and advanced age were significantly associated with sleep disorders in these patients (p = 0.004 and p = 0.006, respectively). We concluded that inflammation has a close relation with sleep disorders in hemodialysis patients.

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Title: Association of inflammatory biomarkers with sleep disorders in hemodialysis patients
Authors: Effat Razeghi
Mohammad Ali Sahraian
Rouhollah Heidari
Mohammad Bagherzadeh
Publication date: 01-03-2012
Publisher: Springer Milan
Published in: Acta Neurologica Belgica / Issue 1/2012
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-012-0003-7

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Springer Medicine

Association of inflammatory biomarkers with sleep disorders in hemodialysis patients

Abstract

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Abstract

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