Top

Published in:

01-04-2018 | Case Report

Malignant triton tumor of the duodenum: report of a case

Authors: Yoh Asahi, Takahito Nakagawa, Katsuya Nakanishi, Tomofumi Takagi, Hiroyuki Yoshikawa, Kazuki Wakizaka, Ryoji Yokoyama, Manabu Takahashi, Fumiaki Sasaki

Published in: International Cancer Conference Journal | Issue 2/2018

Abstract

We report a case of malignant triton tumor of the duodenum, which is extremely rare. A submucosal malignant tumor was detected in the duodenum of a 49-year-old woman. The tumor was completely resected by performing pancreaticoduodenectomy. Pathological examination revealed that the lesion was a malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation, i.e., a malignant triton tumor. Long-term survival has been achieved with no recurrence at 8.5 years after surgery.

Guo A, Liu A, Wei L et al (2012) Malignant peripheral nerve sheath tumors: differentiation patterns and immunohistochemical features—a mini-review and our new findings. J Cancer 3:303–309CrossRefPubMedPubMedCentral

Kolberg M, Høland M, Agesen TH et al (2013) Survival meta-analyses for> 1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1. Neuro Oncol 15:135–147CrossRefPubMed

Ducatman BS, Scheithauer BW, Piepgras DG et al (1986) Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer 57:2006–2021CrossRefPubMed

Woodruff JM, Chernik NL, Smith MC et al (1973) Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant ‘Triton’ tumors). Cancer 32:426–439CrossRefPubMed

Yamamoto T, Minami R, Ohbayashi C (2001) Subcutaneous malignant epithelioid schwannoma with cartilaginous differentiation. J Cutan Pathol 28:486–491CrossRefPubMed

Rodriguez FJ, Scheithauer BW, Abell-Aleff PC et al (2007) Low grade malignant peripheral nerve sheath tumor with smooth muscle differentiation. Acta Neuropathol 113:705–709CrossRefPubMed

Suresh TN, Harendra Kumar ML, Prasad CS et al (2009) Malignant peripheral nerve sheath tumor with divergent differentiation. Indian J Pathol Microbiol 52:74–761CrossRefPubMed

Masson P (1932) Recklinghausen’s neurofibromatosis, sensory neuromas and motor neuromas. Libman Anniversary, vol 2. The International Press, New York, pp 793–802

Li G, Liu C, Liu Y et al (2015) Analysis of clinical features and prognosis of malignant triton tumor: a report of two cases and literature review. Oncol Lett 10:3551–3556CrossRefPubMedPubMedCentral

10.

Lee YJ, Moon HG, Park ST et al (2006) Malignant peripheral nerve sheath tumor arising from the colon in a newborn: report of a case and review of the literatures. J Pediatr Surg 41:e19–e22

11.

Stucky CC, Johnson KN, Gray RJ et al (2012) Malignant peripheral nerve sheath tumors (MPNST): the Mayo Clinic experience. Ann Surg Oncol 19:878–885CrossRefPubMed

12.

Wong WW, Hirose T, Scheithauer BW et al (1998) Malignant peripheral nerve sheath tumor: analysis of treatment outcome. Int J Radiat Oncol Biol Phys 42:351–360CrossRefPubMed

13.

Riccardi VM, Powell PP (1989) Neurofibrosarcoma as a complication of von Recklinghausen neurofibromatosis. Neurofibromatosis 2:152–165PubMed

14.

Neville H, Corpron C, Blakely ML et al (2003) Pediatric neurofibrosarcoma. J Pediatr Surg 38:343–346CrossRefPubMed

15.

Ferner RE, Huson SM, Thomas N et al (2007) Guidelines for the diagnosis and management of individuals with neurofibromatosis 1. J Med Genet 44:81–88CrossRefPubMed

16.

Brooks JS, Freeman M, Enterline HT (1985) Malignant “Triton” tumors. Natural history and immunohistochemistry of nine new cases with literature review. Cancer 55:2543–2549CrossRefPubMed

17.

Nistche M, Reible M, Pflüger KH et al (2014) Malignant triton tumor of the sciatic nerve as a secondary malignancy after extended field radiotherapy and chemotherapy of Hodgkin’s disease. Case Rep Oncol 7:239–245CrossRef

18.

Omar T, Raslan H, EI Sheikh S et al (2014) Low-grade malignant triton tumor of the neck: a case report and review of the literature. Case Rep Pathol 2014:674094PubMedPubMedCentral

19.

Schaefer IM, Fletcher CD, Fomick JL (2015) Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. Mod Pathol 29:4–13CrossRefPubMed

20.

Prieto-Granada CN, Wiesner T, Messina JL et al (2016) Loss of H3K27me3 expression is a highly sensitive marker for sporadic and radiation-induced MPNST. Am J Surg Pathol 40:479–489CrossRefPubMedPubMedCentral

21.

Marano L, Boccardi V, Marrelli D et al (2015) Duodenal gastrointestinal stromal tumor: from clinicopathological features to surgical outcomes. Eur J Surg Oncol 41:814–822CrossRefPubMed

22.

Okabayashi T, Shima Y, Iwata J et al (2013) Primary liposarcoma of the duodenum: a first case presentation. Intern Med 52:2753–2757CrossRefPubMed

23.

West RB, Coriess CL, Chen X et al (2004) The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol 165:107–113CrossRefPubMedPubMedCentral

24.

Binh MB, Sastre-Garau X, Guillou L et al (2005) MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 29:1340–1347CrossRefPubMed

25.

Daimaru Y, Hashimoto H, Enjpji M (1984) Malignant “triton” tumors: a clinicopathologic and immunohistochemical study of nine cases. Hum Pathol 15:768–778CrossRefPubMed

26.

Rekhi B, Jambhekar NA, Puri A et al (2008) Clinicomorphologic features of a series of 10 cases of malignant triton tumors diagnosed over 10 years at a tertiary cancer hospital in Mumbai, India. Ann Diag Pathol 12:90–97CrossRef

27.

Clapp WA, Haas R (1971) Neurofibrosarcoma of the duodenum. J Maine Med Assoc 62:55–56PubMed

28.

Thomson WO, Carachi R, Wood CB et al (1979) Neurofibrosarcoma of the duodenum in von Recklinghausen’s disease. Br J Surg 66:29–30CrossRefPubMed

29.

Melissas J, Schoretsanitis G, Valasiadou K et al (1995) Neurofibrosarcoma of the duodenum. Eur J Surg Oncol 21:571–572CrossRefPubMed

30.

Tanaka N, Nobori M, Furuya T et al (1997) Solitary malignant schwannoma of the duodenum with metastasis to the liver: report of a case. Surg Today Jpn J Surg 27:1173–1176CrossRef

31.

Wanebo JE, Malik JM, VandenBerg SR et al (1993) Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 71:1247–1253CrossRefPubMed

32.

Sordillo PP, Helson L, Hajdu SI et al (1981) Malignant schwannoma—clinical characteristics, survival, and response to therapy. Cancer 47:2503–2509CrossRefPubMed

33.

McConnell YJ, Giacomantonio CA (2012) Malignant triton tumors—complete surgical resection and adjuvant radiotherapy associated with improved survival. J Surg Oncol 106:51–56CrossRefPubMed

34.

Kahn J, Gillespie A, Tsokos M et al (2014) Radiation therapy in management of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. Front Oncol 4:324CrossRefPubMedPubMedCentral

Title: Malignant triton tumor of the duodenum: report of a case
Authors: Yoh Asahi
Takahito Nakagawa
Katsuya Nakanishi
Tomofumi Takagi
Hiroyuki Yoshikawa
Kazuki Wakizaka
Ryoji Yokoyama
Manabu Takahashi
Fumiaki Sasaki
Publication date: 01-04-2018
Publisher: Springer Japan
Published in: International Cancer Conference Journal / Issue 2/2018
Electronic ISSN: 2192-3183
DOI: https://doi.org/10.1007/s13691-018-0320-7

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2018

Successful radiotherapy for endometrial serous carcinoma with local repeated recurrence

Progression to bone-marrow carcinomatosis and extraosseous legion during treatment with radium-223 for multiple bone metastases

A case of mature cystic teratoma with intestinal structures harboring intestinal-type low-grade mucinous neoplasm

Laparoscopic transhiatal lymphadenectomy in the lower mediastinum for adenocarcinoma of the esophagogastric junction

Concurrent combination of irradiation and immune checkpoint inhibitor for recurrent pleomorphic carcinoma of the lung

A case of the cirrhotic patient performed living donor liver transplantation after carbon-ion radiotherapy for hepatocellular carcinoma

Keynote webinar | Spotlight on antibody–drug conjugates in cancer