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Published in: Current Dermatology Reports 4/2019

01-12-2019 | Edema | Wound Care (H Lev-Tov, Section Editor)

Lymphedema: New Concepts in Diagnosis and Treatment

Authors: Robyn Bjork, Heather Hettrick

Published in: Current Dermatology Reports | Issue 4/2019

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Abstract

Purpose of Review

This review’s aim is to coalesce current evidence regarding the lymphatic system and lymphedema, bridge the gap from traditional approaches to emerging concepts, and present simple strategies that can be immediately implemented into everyday clinical practice.

Recent Findings

New evidence of the microcirculation redefines all edema as lymphedema and having the potential to result in chronic inflammation and deleterious soft tissue changes. These soft tissue changes are easily identifiable through simple manual tests that also help direct interventions. CDT is the gold standard of treatment, but components are evolving with the emergence of new technologies and new understandings of mechanobiology. The lymphatic and integumentary systems are interdependent, requiring concurrent lymphedema and wound management strategies.

Summary

Optimization of the lymphatic system is key to edema management and wound healing. Future research is needed to progress individualized diagnostics of lymphatic vasculature so treatment interventions can be customized to each patient.
Literature
2.••
go back to reference Bjork R, Hettrick H. Endothelial glycocalyx layer and interdependence of lymphatic and integumentary systems. Wounds Int. 2018;9(2):50–5 Review of current concepts of Starlings Law vs EGL, structure and function of EGL, and impact on new lymphedema paradigm and lymphatic/integumentary interdependence. Bjork R, Hettrick H. Endothelial glycocalyx layer and interdependence of lymphatic and integumentary systems. Wounds Int. 2018;9(2):50–5 Review of current concepts of Starlings Law vs EGL, structure and function of EGL, and impact on new lymphedema paradigm and lymphatic/integumentary interdependence.
3.
go back to reference Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010 Mar 3;87(2):198–210.PubMed Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010 Mar 3;87(2):198–210.PubMed
4.
go back to reference Bjork R, Hettrick H. Emerging paradigms integrating the lymphatic and integumentary systems: clinical implications. Wound Care Hyberbaric Med. 2018;9(2):15–21. Bjork R, Hettrick H. Emerging paradigms integrating the lymphatic and integumentary systems: clinical implications. Wound Care Hyberbaric Med. 2018;9(2):15–21.
5.
go back to reference Mortimer PS, Rockson SG. New developments in clinical aspects of lymphatic disease. J Clin Invest. 2014 Mar 3;124(3):915–21.PubMedPubMedCentral Mortimer PS, Rockson SG. New developments in clinical aspects of lymphatic disease. J Clin Invest. 2014 Mar 3;124(3):915–21.PubMedPubMedCentral
6.
go back to reference Földi M, Földi E, Strößenreuther R, Kubik S, editors. Földi's textbook of lymphology: for physicians and lymphedema therapists. Elsevier Health Sciences; 2012 Feb 21. Földi M, Földi E, Strößenreuther R, Kubik S, editors. Földi's textbook of lymphology: for physicians and lymphedema therapists. Elsevier Health Sciences; 2012 Feb 21.
7.
go back to reference Carlson A. Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: a locus minoris resistentiae. Clin Dermatol. 2014;32:599–615.PubMed Carlson A. Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: a locus minoris resistentiae. Clin Dermatol. 2014;32:599–615.PubMed
9.
go back to reference Ruocco E, Puca RV, Brunetti G, Schwartz RA, Ruocco V. Lymphedematous areas: privileged sites for tumors, infections, and immune disorders. Int J Dermatol. 2007;46:662.PubMed Ruocco E, Puca RV, Brunetti G, Schwartz RA, Ruocco V. Lymphedematous areas: privileged sites for tumors, infections, and immune disorders. Int J Dermatol. 2007;46:662.PubMed
10.
go back to reference Ruocco V, Schwartz RA, Ruocco E. Lymphedema: an immunologically vulnerable site for development of neoplasms. J Am Acad Dermatol. 2002;47:124–7.PubMed Ruocco V, Schwartz RA, Ruocco E. Lymphedema: an immunologically vulnerable site for development of neoplasms. J Am Acad Dermatol. 2002;47:124–7.PubMed
11.
go back to reference Ridner SH. Pathophysiology of lymphedema. Semin Oncol Nurs. 2013;29:4–11.PubMed Ridner SH. Pathophysiology of lymphedema. Semin Oncol Nurs. 2013;29:4–11.PubMed
12.
go back to reference Framework L. Best practice for the management of lymphoedema. International consensus. London: MEP Ltd; 2006. p. 3–52. Framework L. Best practice for the management of lymphoedema. International consensus. London: MEP Ltd; 2006. p. 3–52.
13.•
go back to reference Executive Committee. The diagnosis and treatment of peripheral lymphedema: 2016 consensus document of the International Society of Lymphology. Lymphology. 2016;49(4):170–84 Current staging of lymphedema. Executive Committee. The diagnosis and treatment of peripheral lymphedema: 2016 consensus document of the International Society of Lymphology. Lymphology. 2016;49(4):170–84 Current staging of lymphedema.
14.
go back to reference Rockson S. Diseases of the lymphatic circulation in vascular medicine: a companion to Braunwald’s heart disease, 2nd Edition. Elsevier; 2013:697–708. Rockson S. Diseases of the lymphatic circulation in vascular medicine: a companion to Braunwald’s heart disease, 2nd Edition. Elsevier; 2013:697–708.
15.
go back to reference Greene A. Diagnosis and management of obesity-inducted lymphedema. Plastic Recon Surgery. 2016;138(1):111e–8e. Greene A. Diagnosis and management of obesity-inducted lymphedema. Plastic Recon Surgery. 2016;138(1):111e–8e.
16.•
go back to reference Wang W, Keast DH. Prevalence and characteristics of lymphoedema at a wound-care clinic. J Wound Care. 2016;25(Sup4):S11–5 Emphasizes role of comorbidities in lymphedema management.PubMed Wang W, Keast DH. Prevalence and characteristics of lymphoedema at a wound-care clinic. J Wound Care. 2016;25(Sup4):S11–5 Emphasizes role of comorbidities in lymphedema management.PubMed
17.
go back to reference Rockson SG, Rivera KK. Estimating the population burden of lymphedema. Ann N Y Acad Sci 2008;1131(1):147–154.PubMed Rockson SG, Rivera KK. Estimating the population burden of lymphedema. Ann N Y Acad Sci 2008;1131(1):147–154.PubMed
18.••
go back to reference Keast DH, Moffatt C, Janmohammad J. Lymphedema IMpact and PRevalence INTernational (LIMPRINT) study: the Canadian data. Lymphat Res Biol. 2019:10 Emphasizes new global recognition of chronic edema as lymphedema and demonstrates need for cross-education and incorporating lymphedema diagnosis and management into wound centers. Keast DH, Moffatt C, Janmohammad J. Lymphedema IMpact and PRevalence INTernational (LIMPRINT) study: the Canadian data. Lymphat Res Biol. 2019:10 Emphasizes new global recognition of chronic edema as lymphedema and demonstrates need for cross-education and incorporating lymphedema diagnosis and management into wound centers.
19.••
go back to reference Bjork R, Ehmann S. STRIDE Professional guide to compression garment selection for the lower extremity. J Wound Care. 2019;28(Sup6a):1–44 New resource for compression selection for optimized management of edema/lymphedema.PubMed Bjork R, Ehmann S. STRIDE Professional guide to compression garment selection for the lower extremity. J Wound Care. 2019;28(Sup6a):1–44 New resource for compression selection for optimized management of edema/lymphedema.PubMed
20.•
go back to reference Lu IM, Dixon JB. Assessment of upper extremity swelling among breast cancer survivors with a commercial infrared sensor. Lymphat Res Biol. 2019;29 Exciting new technology using hand held scanner that makes volume calculation and tracking easier. Lu IM, Dixon JB. Assessment of upper extremity swelling among breast cancer survivors with a commercial infrared sensor. Lymphat Res Biol. 2019;29 Exciting new technology using hand held scanner that makes volume calculation and tracking easier.
21.
go back to reference Greenhowe J, Stephen C, McClymont L, Munnoch DA. Breast oedema following free flap breast reconstruction. Breast. 2017 Aug 1;34:73–6.PubMed Greenhowe J, Stephen C, McClymont L, Munnoch DA. Breast oedema following free flap breast reconstruction. Breast. 2017 Aug 1;34:73–6.PubMed
22.
go back to reference National Lymphedema Network Medical Advisory Committee. NLN position statement: the diagnosis and treatment of lymphedema. NLN. February 2011. National Lymphedema Network Medical Advisory Committee. NLN position statement: the diagnosis and treatment of lymphedema. NLN. February 2011.
23.
go back to reference Rutkowski JM, Boardman KC, Swartz MA. Characterization of lymphangiogenesis in a model of adult skin regeneration. Am J Phys Heart Circ Phys. 2006 Sep;291(3):H1402–10. Rutkowski JM, Boardman KC, Swartz MA. Characterization of lymphangiogenesis in a model of adult skin regeneration. Am J Phys Heart Circ Phys. 2006 Sep;291(3):H1402–10.
24.
go back to reference Scavelli C, Weber E, Aglianò M, Cirulli T, Nico B, Vacca A, et al. Lymphatics at the crossroads of angiogenesis and lymphangiogenesis. J Anat. 2004 Jun;204(6):433–49.PubMedPubMedCentral Scavelli C, Weber E, Aglianò M, Cirulli T, Nico B, Vacca A, et al. Lymphatics at the crossroads of angiogenesis and lymphangiogenesis. J Anat. 2004 Jun;204(6):433–49.PubMedPubMedCentral
25.
go back to reference Solito R, Alessandrini C, Fruschelli M, Pucci AM, Gerli R. An immunological correlation between the ancho ring filaments of initial lymph vessels and the neighboring elastic fibers: a unified morphofunctional concept. Lymphology. 1997;30(4):194–202.PubMed Solito R, Alessandrini C, Fruschelli M, Pucci AM, Gerli R. An immunological correlation between the ancho ring filaments of initial lymph vessels and the neighboring elastic fibers: a unified morphofunctional concept. Lymphology. 1997;30(4):194–202.PubMed
26.
27.
go back to reference Pedersen JA, Boschetti F, Swartz MA. Effects of extracellular fiber architecture on cell membrane shear stress in a 3D fibrous matrix. J Biomech. 2007 Jan 1;40(7):1484–92.PubMed Pedersen JA, Boschetti F, Swartz MA. Effects of extracellular fiber architecture on cell membrane shear stress in a 3D fibrous matrix. J Biomech. 2007 Jan 1;40(7):1484–92.PubMed
28.
go back to reference Swartz MA, Fleury ME. Interstitial flow and its effects in soft tissues. Annu Rev Biomed Eng. 2007 Aug 15;9:229–56.PubMed Swartz MA, Fleury ME. Interstitial flow and its effects in soft tissues. Annu Rev Biomed Eng. 2007 Aug 15;9:229–56.PubMed
29.
go back to reference Rossi A, Weber E, Sacchi G, Maestrini D, Di Cintio F, Gerli R. Mechanotransduction in lymphatic endothelial cells. Lymphology. 2007 Sep 1;40(3):102–13.PubMed Rossi A, Weber E, Sacchi G, Maestrini D, Di Cintio F, Gerli R. Mechanotransduction in lymphatic endothelial cells. Lymphology. 2007 Sep 1;40(3):102–13.PubMed
30.
go back to reference Rutkowski JM, Swartz MA. A driving force for change: interstitial flow as a morphoregulator. Trends Cell Biol. 2007 Jan 1;17(1):44–50.PubMed Rutkowski JM, Swartz MA. A driving force for change: interstitial flow as a morphoregulator. Trends Cell Biol. 2007 Jan 1;17(1):44–50.PubMed
31.
go back to reference Boardman KC, Swartz MA. Interstitial flow as a guide for lymphangiogenesis. Circ Res. 2003 Apr 18;92(7):801–8.PubMed Boardman KC, Swartz MA. Interstitial flow as a guide for lymphangiogenesis. Circ Res. 2003 Apr 18;92(7):801–8.PubMed
32.
go back to reference Gerli R, Solito R, Weber E, Agliano M. Specific adhesion molecules bind anchoring filaments and endothelial cells in human skin initial lymphatics. Lymphology. 2000;33(4):148–57.PubMed Gerli R, Solito R, Weber E, Agliano M. Specific adhesion molecules bind anchoring filaments and endothelial cells in human skin initial lymphatics. Lymphology. 2000;33(4):148–57.PubMed
33.
go back to reference Van Geest AJ, Veraart JC, Nelemans P, Neumann HA. The effect of medical elastic compression stockings with different slope values on edema: measurements underneath three different types of stockings. Dermatol Surg. 2000 Mar;26(3):244–7.PubMed Van Geest AJ, Veraart JC, Nelemans P, Neumann HA. The effect of medical elastic compression stockings with different slope values on edema: measurements underneath three different types of stockings. Dermatol Surg. 2000 Mar;26(3):244–7.PubMed
34.
go back to reference Mosti G. Compression therapy in mixed ulcers. J Med Vasc. 2018;43(4):223–4.PubMed Mosti G. Compression therapy in mixed ulcers. J Med Vasc. 2018;43(4):223–4.PubMed
35.••
go back to reference Rabe E, Partsch H, Hafner J, Lattimer C, Mosti G, Neumann M, et al. Indications for medical compression stockings in venous and lymphatic disorders: an evidence-based consensus statement. Phlebology. 2018;33(3):163–84 Reviews benefits of compression therapy.PubMed Rabe E, Partsch H, Hafner J, Lattimer C, Mosti G, Neumann M, et al. Indications for medical compression stockings in venous and lymphatic disorders: an evidence-based consensus statement. Phlebology. 2018;33(3):163–84 Reviews benefits of compression therapy.PubMed
36.
go back to reference Alavi, et al. What’s new: management of venous leg ulcers: treating leg ulcers. J Am Acad Dermatol April. 2016;74(4):643–61. Alavi, et al. What’s new: management of venous leg ulcers: treating leg ulcers. J Am Acad Dermatol April. 2016;74(4):643–61.
37.
go back to reference Ratliff CR, Yates S, McNichol L, Gray M. Compression for the primary prevention, treatment and prevention of recurrence of venous leg ulcers. J Wound Ostomy Continence Nurse. 2016;43(4):347–64. Ratliff CR, Yates S, McNichol L, Gray M. Compression for the primary prevention, treatment and prevention of recurrence of venous leg ulcers. J Wound Ostomy Continence Nurse. 2016;43(4):347–64.
38.
go back to reference Harding K et al. Simplifying venous leg ulcer management. Consensus recommendations. Wounds International 2015. Harding K et al. Simplifying venous leg ulcer management. Consensus recommendations. Wounds International 2015.
39.
go back to reference Partsch H, Mortimer P. Compression for leg wounds. Br J Dermatol. 2015;173:359–69.PubMed Partsch H, Mortimer P. Compression for leg wounds. Br J Dermatol. 2015;173:359–69.PubMed
40.
go back to reference O’donnell TF, Passman MA, Marston WA, Ennis WJ, Dalsing M, Kistner RL, et al. Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum. J Vasc Surg. 2014 Aug 1;60(2):3S–59S.PubMed O’donnell TF, Passman MA, Marston WA, Ennis WJ, Dalsing M, Kistner RL, et al. Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum. J Vasc Surg. 2014 Aug 1;60(2):3S–59S.PubMed
42.
go back to reference Partsch H, Moffatt C.An overview of the science behind compression bandaging for lymphoedema and chronic oedema In: Compression therapy: A position document on compression bandaging. International Lymphedema Framework in association with the World Alliance for Wound and Lymphoedema Care. 2012:12–22. Partsch H, Moffatt C.An overview of the science behind compression bandaging for lymphoedema and chronic oedema In: Compression therapy: A position document on compression bandaging. International Lymphedema Framework in association with the World Alliance for Wound and Lymphoedema Care. 2012:12–22.
43.
go back to reference Partsch H, Junger M. Evidence for the use of compression hosiery in lymphoedema. Lymphoedema Framework. Template for Practice: compression hosiery in lymphoedema. London: MEP Ltd; 2006. Partsch H, Junger M. Evidence for the use of compression hosiery in lymphoedema. Lymphoedema Framework. Template for Practice: compression hosiery in lymphoedema. London: MEP Ltd; 2006.
44.
go back to reference Muldoon J, Charles H. Clinical effectiveness and patient considerations in oedema management. Journal of Lymphoedema. 2013;8(1):51–5. Muldoon J, Charles H. Clinical effectiveness and patient considerations in oedema management. Journal of Lymphoedema. 2013;8(1):51–5.
45.
go back to reference Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, et al. Manual lymphatic drainage for lymphedema following breast cancer treatment. Cochrane Database Syst Rev. 2015;5. Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, et al. Manual lymphatic drainage for lymphedema following breast cancer treatment. Cochrane Database Syst Rev. 2015;5.
46.
go back to reference Moffatt C, Partsch H, Schuren J, Quéré I, Sneddon M, Flour M, et al. Compression therapy. a position document on compression bandaging. Int Lymphoedema Framework. 2012;2012. Moffatt C, Partsch H, Schuren J, Quéré I, Sneddon M, Flour M, et al. Compression therapy. a position document on compression bandaging. Int Lymphoedema Framework. 2012;2012.
47.
go back to reference Bjork R, Ehmann S. Advanced compression therapy for venous and lymphatic disease. Session 3 presentation, symposium on advanced wound care fall; 2018; Las Vegas, NV. Bjork R, Ehmann S. Advanced compression therapy for venous and lymphatic disease. Session 3 presentation, symposium on advanced wound care fall; 2018; Las Vegas, NV.
48.
go back to reference Partsch H, Schuren J, Mosti G, Benigni JP. The static stiffness index: an important parameter to characterize compression therapy in vivo. J Wound Care. 2016;25(Suppl 9):S4–S10.PubMed Partsch H, Schuren J, Mosti G, Benigni JP. The static stiffness index: an important parameter to characterize compression therapy in vivo. J Wound Care. 2016;25(Suppl 9):S4–S10.PubMed
49.
go back to reference Mosti G. Stiffness of compression devices. Veins and Lymphatics. 2013;2(1):1–2. Mosti G. Stiffness of compression devices. Veins and Lymphatics. 2013;2(1):1–2.
50.
go back to reference Neumann HM. Elasticity, hysteresis and stiffness: the magic triangle. Veins and Lymphatics. 2013;27:e6. Neumann HM. Elasticity, hysteresis and stiffness: the magic triangle. Veins and Lymphatics. 2013;27:e6.
51.
go back to reference Hirai M, Iwata H, Hayakawa N. Effect of elastic compression stockings in patients with varicose veins and healthy controls measured by strain gauge plethysmography. Skin Res Technol. 2012;8:236–9. Hirai M, Iwata H, Hayakawa N. Effect of elastic compression stockings in patients with varicose veins and healthy controls measured by strain gauge plethysmography. Skin Res Technol. 2012;8:236–9.
52.
go back to reference Hirai M, Niimi K, Iwata H, Sugimoto I, Ishibashi H, Ota T, et al. Comparison of stiffness and interface pressure during rest and exercise among various arm sleeves. Phlebology. 2010;25:196–200.PubMed Hirai M, Niimi K, Iwata H, Sugimoto I, Ishibashi H, Ota T, et al. Comparison of stiffness and interface pressure during rest and exercise among various arm sleeves. Phlebology. 2010;25:196–200.PubMed
53.
go back to reference Hirai M, Niimi K, Iwata H, Sugimoto I, Ishibashi H, Ota T, et al. A comparison of interface pressure and stiffness between elastic stockings and bandages. Phlebology. 2009 June;24(3):120–4.PubMed Hirai M, Niimi K, Iwata H, Sugimoto I, Ishibashi H, Ota T, et al. A comparison of interface pressure and stiffness between elastic stockings and bandages. Phlebology. 2009 June;24(3):120–4.PubMed
54.
go back to reference Hirai M, Iwata H, Ishibashi H, Ota T, Nakamura H. Interface pressure and stiffness of various elastic stockings during posture changes and exercise. Vascular. 2008;16(2):95–100.PubMed Hirai M, Iwata H, Ishibashi H, Ota T, Nakamura H. Interface pressure and stiffness of various elastic stockings during posture changes and exercise. Vascular. 2008;16(2):95–100.PubMed
55.
go back to reference Clark M, Krimmel G. Lymphoedema and the construction and classification of compression hosiery. Lymphoedema Framework. Template for Practice: compression hosiery in lymphoedema. London: MEP Ltd; 2006. Clark M, Krimmel G. Lymphoedema and the construction and classification of compression hosiery. Lymphoedema Framework. Template for Practice: compression hosiery in lymphoedema. London: MEP Ltd; 2006.
56.
go back to reference Vander Wegen-Franken K, Roest W, Tank B, Neumann M. Calculating the pressure and stiffness in three different categories of class II medical elastic compression stockings. Dermatol Surg. 2006;32(2):216–23. Vander Wegen-Franken K, Roest W, Tank B, Neumann M. Calculating the pressure and stiffness in three different categories of class II medical elastic compression stockings. Dermatol Surg. 2006;32(2):216–23.
57.
go back to reference Hafner HM, Junger M. The Haemodynamic efficacy of six different compression stockings from compression class 2 in patients suffering from chronic venous insufficiency. Phlebology. 2000;15:126–30. Hafner HM, Junger M. The Haemodynamic efficacy of six different compression stockings from compression class 2 in patients suffering from chronic venous insufficiency. Phlebology. 2000;15:126–30.
58.••
go back to reference Vrieze T, Vos L, Gebruers N, et al. Protocol of a randomized controlled trial regarding the effectiveness of fluoroscopy guided manual lymph drainage for the treatment of breast cancer related lymphedema (EFforT-BCRL trial). Eu J Obstetrics & Gyn Repro Bio. 2018;221:177–88 Highlights new flouroscopy guided manual lymphatic drainage approach. Vrieze T, Vos L, Gebruers N, et al. Protocol of a randomized controlled trial regarding the effectiveness of fluoroscopy guided manual lymph drainage for the treatment of breast cancer related lymphedema (EFforT-BCRL trial). Eu J Obstetrics & Gyn Repro Bio. 2018;221:177–88 Highlights new flouroscopy guided manual lymphatic drainage approach.
59.••
go back to reference Suami H, Scaglioni MF. Anatomy of the lymphatic system and the lymphosome concept with reference to lymphedema. In Seminars in plastic surgery 2018 Feb (Vol. 32, No. 01, pp. 005–011). Thieme Medical Publishers. New lymphosome mapping useful with Bjork Bow Tie Test in identification of lymphedema clinically, as well as directing manual lymphatic drainage. Suami H, Scaglioni MF. Anatomy of the lymphatic system and the lymphosome concept with reference to lymphedema. In Seminars in plastic surgery 2018 Feb (Vol. 32, No. 01, pp. 005–011). Thieme Medical Publishers. New lymphosome mapping useful with Bjork Bow Tie Test in identification of lymphedema clinically, as well as directing manual lymphatic drainage.
61.
go back to reference Granzow J, Soderberg J, Kaji A, Dauphine C. Review of current surgical treatments for lymphedema. Ann Surg Oncol. 2014;21:1195–201.PubMed Granzow J, Soderberg J, Kaji A, Dauphine C. Review of current surgical treatments for lymphedema. Ann Surg Oncol. 2014;21:1195–201.PubMed
62.
go back to reference Charles H. Elephantiasis of the leg. In: Latham A, English TC, editors. A system of treatment, vol. 3. London: Churchill; 1912. Charles H. Elephantiasis of the leg. In: Latham A, English TC, editors. A system of treatment, vol. 3. London: Churchill; 1912.
64.
go back to reference Corliss BA, Azimi MS, Munson JM, Peirce SM, Murfee WL. Macrophages: an inflammatory link between angiogenesis and lymphangiogenesis. Microcirculation. 2016;23(2):95–121.PubMedPubMedCentral Corliss BA, Azimi MS, Munson JM, Peirce SM, Murfee WL. Macrophages: an inflammatory link between angiogenesis and lymphangiogenesis. Microcirculation. 2016;23(2):95–121.PubMedPubMedCentral
65.
go back to reference Mortimer P, Pearson I. Lymphatic function in severe chronic venous insufficiency. Phlebolymphology. 2004;44:249–52. Mortimer P, Pearson I. Lymphatic function in severe chronic venous insufficiency. Phlebolymphology. 2004;44:249–52.
66.
go back to reference Farrow W. Phlebolymphedema- a common underdiagnosed and undertreated problem in the wound care clinic. J Am Coll of Cert Wound Spec. 2010;2:14–23. Farrow W. Phlebolymphedema- a common underdiagnosed and undertreated problem in the wound care clinic. J Am Coll of Cert Wound Spec. 2010;2:14–23.
Metadata
Title
Lymphedema: New Concepts in Diagnosis and Treatment
Authors
Robyn Bjork
Heather Hettrick
Publication date
01-12-2019
Publisher
Springer US
Keywords
Edema
Lymphedema
Published in
Current Dermatology Reports / Issue 4/2019
Electronic ISSN: 2162-4933
DOI
https://doi.org/10.1007/s13671-019-00273-2

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