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Current Dermatology Reports

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01-12-2018 | Atopic Dermatitis (C Vestergaard, Section Editor)

The Skin Microbiome in Atopic Dermatitis—a Potential Treatment Target?

Authors: Caroline Meyer Olesen, Maja-Lisa Clausen, Paal Skytt Andersen, Tove Agner

Published in: Current Dermatology Reports | Issue 4/2018

Abstract

Purpose of Review

Staphylococcus aureus (S. aureus) frequently colonize the skin of patients with atopic dermatitis (AD). The abundance of S. aureus increases during flares, accompanied by a reduction in bacterial diversity. This flare-associated imbalance in the cutaneous microflora (dysbiosis) correlates with disease severity. However, the causality of this association has not yet been fully established, and this review aims to further explore the relation between the skin microbiome and AD along with the clinical implications hereof.

Recent Findings

Recently, it has been shown that the skin microbiome in clinically unaffected skin of AD patients differs from that of healthy individuals. In addition, mutations in the gene encoding the structural protein filaggrin (FLG) have been shown to influence the skin microbiome.

Summary

Skin barrier impairments, which characterize the AD phenotype, influence the skin microbiome and increase the susceptibility to colonization with S. aureus. In turn, S. aureus can promote skin inflammation by a broad spectrum of virulence factors. Modulation of the skin microbiome by transferring beneficial skin commensals to the skin of AD patients may represent a promising strategy for the future management of AD.

Czarnowicki T, Krueger JG, Guttman-Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march. J Allergy Clin Immunol. 2017;139(6):1723–34. https://doi.org/10.1016/j.jaci.2017.04.004.CrossRefPubMed

Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1. https://doi.org/10.1038/s41572-018-0001-z.CrossRefPubMed

Guttman-Yassky E, Waldman A, Ahluwalia J, Ong PY, Eichenfield LF. Atopic dermatitis: pathogenesis. Semin Cutan Med Surg. 2017;36(3):100–3. https://doi.org/10.12788/j.sder.2017.036.CrossRefPubMed

Zhu TH, Zhu TR, Tran KA, Sivamani RK, Shi VY. Epithelial barrier dysfunctions in atopic dermatitis: a skin-gut-lung model linking microbiome alteration and immune dysregulation. Br J Dermatol. 2018;179:570–81. https://doi.org/10.1111/bjd.16734.CrossRefPubMed

Yamazaki Y, Nakamura Y, Nunez G. Role of the microbiota in skin immunity and atopic dermatitis. Allergol Int. 2017;66(4):539–44. https://doi.org/10.1016/j.alit.2017.08.004.CrossRefPubMed

Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012;22(5):850–9. https://doi.org/10.1101/gr.131029.111.CrossRefPubMedPubMedCentral

•• Byrd AL, Deming C, Cassidy SKB, Harrison OJ, Ng WI, Conlan S, et al. Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis. Sci Transl Med. 2017;9(397). https://doi.org/10.1126/scitranslmed.aal4651 A study describing the temporal dynamics of the skin microbiome during the course of AD, demonstrating that the abundance of S. aureus and S. epidermidis increases while bacterial diversity decreases during flares.CrossRefPubMedPubMedCentral

Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9(4):244–53. https://doi.org/10.1038/nrmicro2537.CrossRefPubMedPubMedCentral

Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the human microbiome. Nutr Rev. 2012;70(Suppl 1):S38–44. https://doi.org/10.1111/j.1753-4887.2012.00493.x.CrossRefPubMed

10.

Gupta VK, Paul S, Dutta C. Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity. Front Microbiol. 2017;8:1162. https://doi.org/10.3389/fmicb.2017.01162.CrossRefPubMedPubMedCentral

11.

Musthaq S, Mazuy A, Jakus J. The microbiome in dermatology. Clin Dermatol. 2018;36(3):390–8. https://doi.org/10.1016/j.clindermatol.2018.03.012.CrossRefPubMed

12.

SanMiguel A, Grice EA. Interactions between host factors and the skin microbiome. Cell Mol Life Sci. 2015;72(8):1499–515. https://doi.org/10.1007/s00018-014-1812-z.CrossRefPubMed

13.

Hilton SK, Castro-Nallar E, Perez-Losada M, Toma I, McCaffrey TA, Hoffman EP, et al. Metataxonomic and metagenomic approaches vs. culture-based techniques for clinical pathology. Front Microbiol. 2016;7:484. https://doi.org/10.3389/fmicb.2016.00484.CrossRefPubMedPubMedCentral

14.

Mathieu A, Vogel TM, Simonet P. The future of skin metagenomics. Res Microbiol. 2014;165(2):69–76. https://doi.org/10.1016/j.resmic.2013.12.002.CrossRefPubMed

15.

Jovel J, Patterson J, Wang W, Hotte N, O'Keefe S, Mitchel T, et al. Characterization of the gut microbiome using 16S or shotgun metagenomics. Front Microbiol. 2016;7:459. https://doi.org/10.3389/fmicb.2016.00459.CrossRefPubMedPubMedCentral

16.

Kong HH, Andersson B, Clavel T, Common JE, Jackson SA, Olson ND, et al. Performing skin microbiome research: a method to the madness. J Invest Dermatol. 2017;137(3):561–8. https://doi.org/10.1016/j.jid.2016.10.033.CrossRefPubMedPubMedCentral

17.

Ranjan R, Rani A, Metwally A, McGee HS, Perkins DL. Analysis of the microbiome: advantages of whole genome shotgun versus 16S amplicon sequencing. Biochem Biophys Res Commun. 2016;469(4):967–77. https://doi.org/10.1016/j.bbrc.2015.12.083.CrossRefPubMed

18.

Meisel JS, Hannigan GD, Tyldsley AS, SanMiguel AJ, Hodkinson BP, Zheng Q, et al. Skin microbiome surveys are strongly influenced by experimental design. J Invest Dermatol. 2016;136(5):947–56. https://doi.org/10.1016/j.jid.2016.01.016.CrossRefPubMedPubMedCentral

19.

Bjerre RD, Bandier J, Skov L, Engstrand L, Johansen JD. The role of the skin microbiome in atopic dermatitis: a systematic review. Br J Dermatol. 2017;177(5):1272–8. https://doi.org/10.1111/bjd.15390.CrossRefPubMed

20.

Clausen ML, Agner T. Antimicrobial peptides, infections and the skin barrier. Curr Probl Dermatol. 2016;49:38–46. https://doi.org/10.1159/000441543.CrossRefPubMed

21.

Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, et al. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009;15(12):1377–82. https://doi.org/10.1038/nm.2062.CrossRefPubMedPubMedCentral

22.

Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, et al. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol. 2010;130(9):2211–21. https://doi.org/10.1038/jid.2010.123.CrossRefPubMedPubMedCentral

23.

Meisel JS, Sfyroera G, Bartow-McKenney C, Gimblet C, Bugayev J, Horwinski J, et al. Commensal microbiota modulate gene expression in the skin. Microbiome. 2018;6(1):20. https://doi.org/10.1186/s40168-018-0404-9.CrossRefPubMedPubMedCentral

24.

Wanke I, Steffen H, Christ C, Krismer B, Gotz F, Peschel A, et al. Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways. J Invest Dermatol. 2011;131(2):382–90. https://doi.org/10.1038/jid.2010.328.CrossRefPubMed

25.

• Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, et al. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017;9(378). https://doi.org/10.1126/scitranslmed.aah4680 A study demonstrating that AMP-producing coagulase-negative staphylococci are common in healty individuals, but rare in AD patients, and that these strains are able to inhibit S. aureus growth.CrossRefPubMedPubMedCentral

26.

Francuzik W, Franke K, Schumann RR, Heine G, Worm M. Propionibacterium acnes abundance correlates inversely with Staphylococcus aureus: data from atopic dermatitis skin microbiome. Acta Derm Venereol. 2018;98(5):490–5. https://doi.org/10.2340/00015555-2896.CrossRefPubMed

27.

Paharik AE, Parlet CP, Chung N, Todd DA, Rodriguez EI, Van Dyke MJ, et al. Coagulase-negative staphylococcal strain prevents Staphylococcus aureus colonization and skin infection by blocking quorum sensing. Cell Host Microbe. 2017;22(6):746–56.e5. https://doi.org/10.1016/j.chom.2017.11.001.CrossRefPubMedPubMedCentral

28.

Strober W. Epithelial cells pay a Toll for protection. Nat Med. 2004;10(9):898–900. https://doi.org/10.1038/nm0904-898.CrossRefPubMed

29.

Fukao T, Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 2003;24(7):358–63.CrossRefPubMed

30.

Shi B, Bangayan NJ, Curd E, Taylor PA, Gallo RL, Leung DYM, et al. The skin microbiome is different in pediatric versus adult atopic dermatitis. J Allergy Clin Immunol. 2016;138(4):1233–6. https://doi.org/10.1016/j.jaci.2016.04.053.CrossRefPubMedPubMedCentral

31.

•• Clausen ML, Agner T, Lilje B, Edslev SM, Johannesen TB, Andersen PS. Association of Disease Severity With Skin Microbiome and Filaggrin Gene Mutations in Adult Atopic Dermatitis. JAMA Dermatol. 2018;154(3):293–300. https://doi.org/10.1001/jamadermatol.2017.5440 A study showing that the composition of the skin microbiome in non-lesional AD skin differs from that of healthy individuals with decreased bacterial diversity and increased abundance of staphylococci, and that FLG mutations influence the skin mirobiome composition.CrossRefPubMedPubMedCentral

32.

•• Clausen ML, Edslev SM, Andersen PS, Clemmensen K, Krogfelt KA, Agner T. Staphylococcus aureus colonization in atopic eczema and its association with filaggrin gene mutations. Br J Dermatol. 2017. https://doi.org/10.1111/bjd.15470 A study demonstratring that S. aureus strains colonizing AD patients differ from those of healthy individuals, and that FLG mutations are related to increased S. aureus colonization and colonization with CC1 strains.CrossRefPubMed

33.

Di Domenico EG, Cavallo I, Bordignon V, Prignano G, Sperduti I, Gurtner A, et al. Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis. Sci Rep. 2018;8(1):9573. https://doi.org/10.1038/s41598-018-27421-1.CrossRefPubMedPubMedCentral

34.

Alsterholm M, Strombeck L, Ljung A, Karami N, Widjestam J, Gillstedt M, et al. Variation in Staphylococcus aureus colonization in relation to disease severity in adults with atopic dermatitis during a five-month follow-up. Acta Derm Venereol. 2017;97(7):802–7. https://doi.org/10.2340/00015555-2667.CrossRefPubMed

35.

Totte JE, van der Feltz WT, Hennekam M, van Belkum A, van Zuuren EJ, Pasmans SG. Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis. Br J Dermatol. 2016;175(4):687–95. https://doi.org/10.1111/bjd.14566.CrossRefPubMed

36.

Park HY, Kim CR, Huh IS, Jung MY, Seo EY, Park JH, et al. Staphylococcus aureus colonization in acute and chronic skin lesions of patients with atopic dermatitis. Ann Dermatol. 2013;25(4):410–6. https://doi.org/10.5021/ad.2013.25.4.410.CrossRefPubMedPubMedCentral

37.

Gonzalez ME, Schaffer JV, Orlow SJ, Gao Z, Li H, Alekseyenko AV, et al. Cutaneous microbiome effects of fluticasone propionate cream and adjunctive bleach baths in childhood atopic dermatitis. J Am Acad Dermatol. 2016;75(3):481–93.e8. https://doi.org/10.1016/j.jaad.2016.04.066.CrossRefPubMedPubMedCentral

38.

Oh J, Freeman AF, Park M, Sokolic R, Candotti F, Holland SM, et al. The altered landscape of the human skin microbiome in patients with primary immunodeficiencies. Genome Res. 2013;23(12):2103–14. https://doi.org/10.1101/gr.159467.113.CrossRefPubMedPubMedCentral

39.

Hon KL, Tsang YC, Pong NH, Leung TF, Ip M. Exploring Staphylococcus epidermidis in atopic eczema: friend or foe? Clin Exp Dermatol. 2016;41(6):659–63. https://doi.org/10.1111/ced.12866.CrossRefPubMed

40.

Clausen ML, Edslev SM, Norreslet LB, Sorensen JA, Andersen PS, Agner T. Temporal variation of Staphylococcus aureus clonal complexes in atopic dermatitis - a follow up study. Br J Dermatol. 2018. https://doi.org/10.1111/bjd.17033.

41.

Messina JA, Thaden JT, Sharma-Kuinkel BK, Fowler VG Jr. Impact of bacterial and human genetic variation on Staphylococcus aureus infections. PLoS Pathog. 2016;12(1):e1005330. https://doi.org/10.1371/journal.ppat.1005330.CrossRefPubMedPubMedCentral

42.

Rojo A, Aguinaga A, Monecke S, Yuste JR, Gastaminza G, Espana A. Staphylococcus aureus genomic pattern and atopic dermatitis: may factors other than superantigens be involved? Eur J Clin Microbiol Infect Dis. 2014;33(4):651–8. https://doi.org/10.1007/s10096-013-2000-z.CrossRefPubMed

43.

Yeung M, Balma-Mena A, Shear N, Simor A, Pope E, Walsh S, et al. Identification of major clonal complexes and toxin producing strains among Staphylococcus aureus associated with atopic dermatitis. Microbes Infect. 2011;13(2):189–97. https://doi.org/10.1016/j.micinf.2010.10.023.CrossRefPubMed

44.

Geoghegan JA, Irvine AD, Foster TJ. Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship. Trends Microbiol. 2018;26(6):484–97. https://doi.org/10.1016/j.tim.2017.11.008.CrossRefPubMed

45.

•• Chng KR, Tay AS, Li C, Ng AH, Wang J, Suri BK, et al. Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare. Nat Microbiol. 2016;1(9):16106. https://doi.org/10.1038/nmicrobiol.2016.106 A study exploring the skin microbiome in AD, illustrating significant differences between the composition of the skin microbiome in non-lesional AD skin and healthy skin. The findings suggest that benificial skin commensals fail to thrive in AD skin making the skin more susceptible to S. aureus colonization.CrossRefPubMed

46.

• Baurecht H, Ruhlemann MC, Rodriguez E, Thielking F, Harder I, Erkens AS, et al. Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration. J Allergy Clin Immunol. 2018;141(5):1668–76.e16. https://doi.org/10.1016/j.jaci.2018.01.019 A study demonstrating how skin abnormalities (lipid composition, FLG mutation) in non-lesional AD skin are related to the microbiome composition.CrossRefPubMed

47.

Elias PM. Primary role of barrier dysfunction in the pathogenesis of atopic dermatitis. Exp Dermatol. 2018;27(8):847–51. https://doi.org/10.1111/exd.13693.CrossRefPubMed

48.

Brown SJ, McLean WH. One remarkable molecule: filaggrin. J Invest Dermatol. 2012;132(3 Pt 2):751–62. https://doi.org/10.1038/jid.2011.393.CrossRefPubMed

49.

Saintive S, Abad E, D CF, Stambovsky M, Cavalcante FS, Goncalves LS, et al. What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis? Future Microbiol. 2017;12:1327–34. https://doi.org/10.2217/fmb-2017-0081.CrossRefPubMed

50.

Gonzalez T, Biagini Myers JM, Herr AB, Khurana Hershey GK. Staphylococcal biofilms in atopic dermatitis. Curr Allergy Asthma Rep. 2017;17(12):81. https://doi.org/10.1007/s11882-017-0750-x.CrossRefPubMedPubMedCentral

51.

Miajlovic H, Fallon PG, Irvine AD, Foster TJ. Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus. J Allergy Clin Immunol. 2010;126(6):1184–90.e3. https://doi.org/10.1016/j.jaci.2010.09.015.CrossRefPubMedPubMedCentral

52.

Cho SH, Strickland I, Boguniewicz M, Leung DY. Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin. J Allergy Clin Immunol. 2001;108(2):269–74. https://doi.org/10.1067/mai.2001.117455.CrossRefPubMed

53.

Clausen ML, Slotved HC, Krogfelt KA, Andersen PS, Agner T. In vivo expression of antimicrobial peptides in atopic dermatitis. Exp Dermatol. 2016;25(1):3–9. https://doi.org/10.1111/exd.12831.CrossRefPubMed

54.

Williams MR, Gallo RL. Evidence that human skin microbiome dysbiosis promotes atopic dermatitis. J Invest Dermatol. 2017;137(12):2460–1. https://doi.org/10.1016/j.jid.2017.09.010.CrossRefPubMedPubMedCentral

55.

Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Munoz-Planillo R, Hasegawa M, et al. Staphylococcus delta-toxin induces allergic skin disease by activating mast cells. Nature. 2013;503(7476):397–401. https://doi.org/10.1038/nature12655.CrossRefPubMedPubMedCentral

56.

Williams MR, Nakatsuji T, Gallo RL. Staphylococcus aureus: master manipulator of the skin. Cell Host Microbe. 2017;22(5):579–81. https://doi.org/10.1016/j.chom.2017.10.015.CrossRefPubMedPubMedCentral

57.

Iwamoto K, Moriwaki M, Niitsu Y, Saino M, Takahagi S, Hisatsune J, et al. Staphylococcus aureus from atopic dermatitis skin alters cytokine production triggered by monocyte-derived Langerhans cell. J Dermatol Sci. 2017;88(3):271–9. https://doi.org/10.1016/j.jdermsci.2017.08.001.CrossRefPubMed

58.

Williams MR, Nakatsuji T, Sanford JA, Vrbanac AF, Gallo RL. Staphylococcus aureus induces increased serine protease activity in keratinocytes. J Invest Dermatol. 2017;137(2):377–84. https://doi.org/10.1016/j.jid.2016.10.008.CrossRefPubMed

59.

Voegeli R, Rawlings AV, Breternitz M, Doppler S, Schreier T, Fluhr JW. Increased stratum corneum serine protease activity in acute eczematous atopic skin. Br J Dermatol. 2009;161(1):70–7. https://doi.org/10.1111/j.1365-2133.2009.09142.x.CrossRefPubMed

60.

•• Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan DH, et al. Dysbiosis and Staphylococcus aureus colonization drives inflammation in atopic dermatitis. Immunity. 2015;42(4):756–66. https://doi.org/10.1016/j.immuni.2015.03.014 A study using a murine model of AD, demonstrating that skin inflammation is almost eliminated and the AD-associated dysbiosis reverted when S. aureus are targeted by selective antibiotics, thereby indicating causality.CrossRefPubMedPubMedCentral

61.

•• Kennedy EA, Connolly J, Hourihane JO, Fallon PG, McLean WH, Murray D, et al. Skin microbiome before development of atopic dermatitis: early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol. 2017;139(1):166–72. https://doi.org/10.1016/j.jaci.2016.07.029 A study investigating whether dysbiosis exists prior to initial development of AD. The findings suggest that early colonization by commensal staphylococci is related to the decreased risk of AD development, and that S. aureus colonization takes place subsequent to AD development.CrossRefPubMedPubMedCentral

62.

• Meylan P, Lang C, Mermoud S, Johannsen A, Norrenberg S, Hohl D, et al. Skin colonization by Staphylococcus aureus precedes the clinical diagnosis of atopic dermatitis in infancy. J Invest Dermatol. 2017;137(12):2497–504. https://doi.org/10.1016/j.jid.2017.07.834 A study indicating that dysbiosis and increased S. aureus abundance in infants are related to subsequent development of AD.CrossRefPubMed

63.

Werfel T, Schwerk N, Hansen G, Kapp A. The diagnosis and graded therapy of atopic dermatitis. Deutsch Arztebl Int. 2014;111(29–30):509–20, i. https://doi.org/10.3238/arztebl.2014.0509.CrossRef

64.

Bath-Hextall FJ, Birnie AJ, Ravenscroft JC, Williams HC. Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review. Br J Dermatol. 2010;163(1):12–26. https://doi.org/10.1111/j.1365-2133.2010.09743.x.CrossRefPubMed

65.

Wrobel J, Tomczak H, Jenerowicz D, Czarnecka-Operacz M. Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients. Ann Agric Environ Med. 2018;25(2):334–7. https://doi.org/10.26444/aaem/85589.CrossRefPubMed

66.

Huang JT, Abrams M, Tlougan B, Rademaker A, Paller AS. Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics. 2009;123(5):e808–14. https://doi.org/10.1542/peds.2008-2217.CrossRefPubMed

67.

Myles IA, Williams KW, Reckhow JD, Jammeh ML, Pincus NB, Sastalla I, et al. Transplantation of human skin microbiota in models of atopic dermatitis. JCI Insight. 2016;1(10). https://doi.org/10.1172/jci.insight.86955.

68.

Gueniche A, Knaudt B, Schuck E, Volz T, Bastien P, Martin R, et al. Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study. Br J Dermatol. 2008;159(6):1357–63. https://doi.org/10.1111/j.1365-2133.2008.08836.x.CrossRefPubMed

69.

Glatz M, Jo JH, Kennedy EA, Polley EC, Segre JA, Simpson EL, et al. Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis. PLoS One. 2018;13(2):e0192443. https://doi.org/10.1371/journal.pone.0192443.CrossRefPubMedPubMedCentral

70.

Simpson EL, Chalmers JR, Hanifin JM, Thomas KS, Cork MJ, McLean WH, et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol. 2014;134(4):818–23. https://doi.org/10.1016/j.jaci.2014.08.005.CrossRefPubMedPubMedCentral

71.

Simpson EL, Berry TM, Brown PA, Hanifin JM. A pilot study of emollient therapy for the primary prevention of atopic dermatitis. J Am Acad Dermatol. 2010;63(4):587–93. https://doi.org/10.1016/j.jaad.2009.11.011.CrossRefPubMedPubMedCentral

72.

Edslev SM, Clausen ML, Agner T, Stegger M, Andersen PS. Genomic analysis reveals different mechanisms of fusidic acid resistance in Staphylococcus aureus from Danish atopic dermatitis patients. J Antimicrob Chemother. 2018;73(4):856–61. https://doi.org/10.1093/jac/dkx481.CrossRefPubMed

Title: The Skin Microbiome in Atopic Dermatitis—a Potential Treatment Target?
Authors: Caroline Meyer Olesen
Maja-Lisa Clausen
Paal Skytt Andersen
Tove Agner
Publication date: 01-12-2018
Publisher: Springer US
Published in: Current Dermatology Reports / Issue 4/2018
Electronic ISSN: 2162-4933
DOI: https://doi.org/10.1007/s13671-018-0245-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The Skin Microbiome in Atopic Dermatitis—a Potential Treatment Target?

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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