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01-12-2017 | Original Research

The effect of resveratrol administration in irradiated mice on the induction of micronuclei in bone marrow

Authors: Farideh Koohian, Ahmad Shanei, Daryoush Shahbazi-Gahrouei, Seyed Hossein Hejazi, Amirhossein Ahmadi, Mohammadreza Sharifi

Published in: Journal of Radiation Oncology | Issue 4/2017

Abstract

Objective

Resveratrol (RSV) a medicinal polyphenol is synthesized by many plants in response to injury, infection, stress, and ultraviolet (UV) irradiation, present in the grapes, nuts, fruits, and wine.

Methods

In this study, we have investigated the antioxidant ability of RSV and its activity in the protection of radiation-induced DNA injury in X-radiated mice. The antioxidant strength of RSV was evaluated by the study of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging properties.

Results

Our results demonstrated that RSV shows strong antioxidant activity by this assay. When mice were exposed to 2 Gy X-radiation, there was an increase in the total MnPCE value and a decrease in the ratio [PCEs/ (PCEs + NCEs)] of bone marrow cells. RSV (50 mg/kg) pretreatment remarkably decreased the total MnPCE value and increased the ratio [PCEs/ (PCEs + NCEs)] in irradiated mice.

Conclusions

These results propose that RSV protects X-radiation-induced DNA damage in mice bone marrow cells, which may be related to its antioxidant activity.

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Title: The effect of resveratrol administration in irradiated mice on the induction of micronuclei in bone marrow
Authors: Farideh Koohian
Ahmad Shanei
Daryoush Shahbazi-Gahrouei
Seyed Hossein Hejazi
Amirhossein Ahmadi
Mohammadreza Sharifi
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Journal of Radiation Oncology / Issue 4/2017
Print ISSN: 1948-7894
Electronic ISSN: 1948-7908
DOI: https://doi.org/10.1007/s13566-017-0324-5

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Abstract

Objective

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