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Published in: Journal of Radiation Oncology 3/2016

01-09-2016 | Original Research

Transcatheter aortic valve replacement in patients with prior chest irradiation and severe aortic stenosis

Authors: Michael P. Chrissoheris, Adamantios Tsangaris, Antonios Chalapas, Konstantinos Spargias

Published in: Journal of Radiation Oncology | Issue 3/2016

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Abstract

Background/methods

Transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis, prior chest irradiation, and porcelain aorta may be preferable to traditional surgery but has not been previously evaluated.

Results

Ten patients (mean age 60 years, 50 % male) with severe aortic stenosis (valve area 0.68 ± 0.15 cm2), prior chest irradiation for malignancy, and porcelain aorta underwent TAVR (transfemoral in 90 %). The procedure was successful in all patients with average ICU stay of 1.2 ± 0.6 days, overall hospital stay of 4.8 ± 1.8 days, and 30-day mortality of 0 %.

Conclusions

TAVR is a safe and effective alternative treatment in aortic stenosis patients with prior chest irradiation and porcelain aorta and may very well become the preferred approach.
Literature
1.
go back to reference Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Brown DL, Block PC, Guyton RA, Pichard AD, Bavaria JE, Herrmann HC, Douglas PS, Petersen JL, Akin JJ, Anderson WN, Wang D, Pocock S, Investigators PT (2010) Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363:1597–1607CrossRefPubMed Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Brown DL, Block PC, Guyton RA, Pichard AD, Bavaria JE, Herrmann HC, Douglas PS, Petersen JL, Akin JJ, Anderson WN, Wang D, Pocock S, Investigators PT (2010) Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363:1597–1607CrossRefPubMed
2.
go back to reference Smith CR, Leon MB, Mack MJ, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Williams M, Dewey T, Kapadia S, Babaliaros V, Thourani VH, Corso P, Pichard AD, Bavaria JE, Herrmann HC, Akin JJ, Anderson WN, Wang D, Pocock SJ, Investigators PT (2011) Transcatheter versus surgical aortic-valve replacement in high-risk patients. New England J Med 364:2187–2198CrossRef Smith CR, Leon MB, Mack MJ, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Williams M, Dewey T, Kapadia S, Babaliaros V, Thourani VH, Corso P, Pichard AD, Bavaria JE, Herrmann HC, Akin JJ, Anderson WN, Wang D, Pocock SJ, Investigators PT (2011) Transcatheter versus surgical aortic-valve replacement in high-risk patients. New England J Med 364:2187–2198CrossRef
3.
go back to reference Linke A, Wenaweser P, Gerckens U, Tamburino C, Bosmans J, Bleiziffer S, Blackman D, Schafer U, Muller R, Sievert H, Sondergaard L, Klugmann S, Hoffmann R, Tchetche D, Colombo A, VM Legrand, Bedogni F, Leprince P, Schuler G, Mazzitelli D, Eftychiou C, Frerker C, Boekstegers P, Windecker S, FW Mohr, Woitek F, Lange R, Bauernschmitt R, Brecker S and For the ADVANCE Study Investigators. Treatment of aortic stenosis with a self-expanding transcatheter valve: the International Multi-centre ADVANCE Study. European heart journal. 2014. Linke A, Wenaweser P, Gerckens U, Tamburino C, Bosmans J, Bleiziffer S, Blackman D, Schafer U, Muller R, Sievert H, Sondergaard L, Klugmann S, Hoffmann R, Tchetche D, Colombo A, VM Legrand, Bedogni F, Leprince P, Schuler G, Mazzitelli D, Eftychiou C, Frerker C, Boekstegers P, Windecker S, FW Mohr, Woitek F, Lange R, Bauernschmitt R, Brecker S and For the ADVANCE Study Investigators. Treatment of aortic stenosis with a self-expanding transcatheter valve: the International Multi-centre ADVANCE Study. European heart journal. 2014.
4.
5.
go back to reference Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K, Mabuchi K, Marks LB, Mettler FA, Pierce LJ, Trott KR, Yeh ET, Shore RE (2010) Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys 76:656–665CrossRefPubMedPubMedCentral Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K, Mabuchi K, Marks LB, Mettler FA, Pierce LJ, Trott KR, Yeh ET, Shore RE (2010) Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys 76:656–665CrossRefPubMedPubMedCentral
6.
go back to reference Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, Durand JB, Gibbs H, Zafarmand AA, Ewer MS (2004) Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation 109:3122–3131CrossRefPubMed Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, Durand JB, Gibbs H, Zafarmand AA, Ewer MS (2004) Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation 109:3122–3131CrossRefPubMed
7.
go back to reference Nadlonek NA, Weyant MJ, Yu JA, Cleveland JC Jr., Reece TB, Meng X, Fullerton DA (2012) Radiation induces osteogenesis in human aortic valve interstitial cells. J Thorac Cardiovasc Surg 144:1466–1470CrossRefPubMedPubMedCentral Nadlonek NA, Weyant MJ, Yu JA, Cleveland JC Jr., Reece TB, Meng X, Fullerton DA (2012) Radiation induces osteogenesis in human aortic valve interstitial cells. J Thorac Cardiovasc Surg 144:1466–1470CrossRefPubMedPubMedCentral
8.
go back to reference Heidenreich PA, Hancock SL, Lee BK, Mariscal CS, Schnittger I (2003) Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol 42:743–749CrossRefPubMed Heidenreich PA, Hancock SL, Lee BK, Mariscal CS, Schnittger I (2003) Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol 42:743–749CrossRefPubMed
9.
go back to reference Zahn R, Schiele R, Gerckens U, Linke A, Sievert H, Kahlert P, Hambrecht R, Sack S, Abdel-Wahab M, Hoffmann E, Senges J, German Transcatheter Aortic Valve Interventions Registry I (2013) Transcatheter aortic valve implantation in patients with “porcelain” aorta (from a Multicenter Real World Registry). Am J Cardiol 111:602–608CrossRefPubMed Zahn R, Schiele R, Gerckens U, Linke A, Sievert H, Kahlert P, Hambrecht R, Sack S, Abdel-Wahab M, Hoffmann E, Senges J, German Transcatheter Aortic Valve Interventions Registry I (2013) Transcatheter aortic valve implantation in patients with “porcelain” aorta (from a Multicenter Real World Registry). Am J Cardiol 111:602–608CrossRefPubMed
10.
go back to reference Rice DC, Klodell CT Jr., Bergbauer RJ, Karimi A, Peng YG, Rehfeldt KH (2011) Case 7-2011: perioperative challenges of valvular replacement in patients after mediastinal radiation therapy. J Cardiothorac Vasc Anesth 25:1200–1203CrossRefPubMed Rice DC, Klodell CT Jr., Bergbauer RJ, Karimi A, Peng YG, Rehfeldt KH (2011) Case 7-2011: perioperative challenges of valvular replacement in patients after mediastinal radiation therapy. J Cardiothorac Vasc Anesth 25:1200–1203CrossRefPubMed
11.
go back to reference Handa N, McGregor CG, Danielson GK, Daly RC, Dearani JA, Mullany CJ, Orszulak TA, Schaff HV, Zehr KJ, Anderson BJ, Schomberg PJ, Puga FJ (2001) Valvular heart operation in patients with previous mediastinal radiation therapy. Ann Thorac Surg 71:1880–1884CrossRefPubMed Handa N, McGregor CG, Danielson GK, Daly RC, Dearani JA, Mullany CJ, Orszulak TA, Schaff HV, Zehr KJ, Anderson BJ, Schomberg PJ, Puga FJ (2001) Valvular heart operation in patients with previous mediastinal radiation therapy. Ann Thorac Surg 71:1880–1884CrossRefPubMed
12.
go back to reference Clavel MA, Webb JG, Pibarot P, Altwegg L, Dumont E, Thompson C, De Larochelliere R, Doyle D, Masson JB, Bergeron S, Bertrand OF, Rodes-Cabau J (2009) Comparison of the hemodynamic performance of percutaneous and surgical bioprostheses for the treatment of severe aortic stenosis. J Am Coll Cardiol 53:1883–1891CrossRefPubMed Clavel MA, Webb JG, Pibarot P, Altwegg L, Dumont E, Thompson C, De Larochelliere R, Doyle D, Masson JB, Bergeron S, Bertrand OF, Rodes-Cabau J (2009) Comparison of the hemodynamic performance of percutaneous and surgical bioprostheses for the treatment of severe aortic stenosis. J Am Coll Cardiol 53:1883–1891CrossRefPubMed
13.
go back to reference Kalavrouziotis D, Rodes-Cabau J, Bagur R, Doyle D, De Larochelliere R, Pibarot P, Dumont E (2011) Transcatheter aortic valve implantation in patients with severe aortic stenosis and small aortic annulus. J Am Coll Cardiol 58:1016–1024CrossRefPubMed Kalavrouziotis D, Rodes-Cabau J, Bagur R, Doyle D, De Larochelliere R, Pibarot P, Dumont E (2011) Transcatheter aortic valve implantation in patients with severe aortic stenosis and small aortic annulus. J Am Coll Cardiol 58:1016–1024CrossRefPubMed
Metadata
Title
Transcatheter aortic valve replacement in patients with prior chest irradiation and severe aortic stenosis
Authors
Michael P. Chrissoheris
Adamantios Tsangaris
Antonios Chalapas
Konstantinos Spargias
Publication date
01-09-2016
Publisher
Springer Berlin Heidelberg
Published in
Journal of Radiation Oncology / Issue 3/2016
Print ISSN: 1948-7894
Electronic ISSN: 1948-7908
DOI
https://doi.org/10.1007/s13566-016-0251-x

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