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01-02-2019 | Case Report

Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

Authors: G. Classen, C. Classen, C. Bernasconi, C. Brandt, R. Gold, A. Chan, R. Hoepner

Published in: Journal of NeuroVirology | Issue 1/2019

Abstract

Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88%) and specificity (82%) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.

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Amplitude spectrum was calculated with Welch’s spectral estimation using the Matlab function “pwelch.m” between 0.5 and 30 Hz with a resolution of 0.1 Hz (Matlab, MathWorks Inc. Natick, Massachusetts, USA).

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Title: Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy
Authors: G. Classen
C. Classen
C. Bernasconi
C. Brandt
R. Gold
A. Chan
R. Hoepner
Publication date: 01-02-2019
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 1/2019
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0689-2

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Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

Abstract

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Abstract

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