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Published in: Journal of NeuroVirology 6/2018

01-12-2018

Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada

Authors: K. Pabbaraju, K. Fonseca, S. Wong, M. W. Koch, J. T. Joseph, G. A. Tipples, R. Tellier

Published in: Journal of NeuroVirology | Issue 6/2018

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Abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive and eventually fatal neurological disease arising from a persistent infection with measles virus (MV) acquired at a young age. SSPE measles virus strains are defective and unable to produce progeny virions, due to multiple and extensive mutations in a number of key genes. We sequenced the full MV genome from our recently reported SSPE case, which typed as genotype D6, and compared it with other genotype D6 wild type and SSPE sequences. The Alberta D6 strain was significantly different from other reported SSPE D6 sequences. Mutations were observed in all the genes of the Alberta strain, with the greatest sequence divergence noted in the M gene with 17.6% nucleotide and 31% amino acid variation. The L gene showed the least variation with 1.3% nucleotide and 0.7% amino acid differences respectively. The nucleotide variability for 15,672 bases of the complete genome compared to the wild type and other SSPE D6 strains was around 3%.
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Metadata
Title
Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada
Authors
K. Pabbaraju
K. Fonseca
S. Wong
M. W. Koch
J. T. Joseph
G. A. Tipples
R. Tellier
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 6/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-018-0668-7

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