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01-04-2018 | Review

An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

Authors: Sarah E. Beck, Suzanne E. Queen, Kelly A. Metcalf Pate, Lisa M. Mangus, Celina M. Abreu, Lucio Gama, Kenneth W. Witwer, Robert J. Adams, M. Christine Zink, Janice E. Clements, Joseph L. Mankowski

Published in: Journal of NeuroVirology | Issue 2/2018

Abstract

Simian immunodeficiency virus (SIV) infection of pigtailed macaques is a highly representative and well-characterized animal model for HIV neuropathogenesis studies that provides an excellent opportunity to study and develop prognostic markers of HIV-associated neurocognitive disorders (HAND) for HIV-infected individuals. SIV studies can be performed in a controlled setting that enhances reproducibility and offers high-translational value. Similar to observations in HIV-infected patients receiving antiretroviral therapy (ART), ongoing neurodegeneration and inflammation are present in SIV-infected pigtailed macaques treated with suppressive ART. By developing quantitative viral outgrowth assays that measure both CD4+ T cells and macrophages harboring replication competent SIV as well as a highly sensitive mouse-based viral outgrowth assay, we have positioned the SIV/pigtailed macaque model to advance our understanding of latent cellular reservoirs, including potential CNS reservoirs, to promote HIV cure. In addition to contributing to our understanding of the pathogenesis of HAND, the SIV/pigtailed macaque model also provides an excellent opportunity to test innovative approaches to eliminate the latent HIV reservoir in the brain.

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Title: An SIV/macaque model targeted to study HIV-associated neurocognitive disorders
Authors: Sarah E. Beck
Suzanne E. Queen
Kelly A. Metcalf Pate
Lisa M. Mangus
Celina M. Abreu
Lucio Gama
Kenneth W. Witwer
Robert J. Adams
M. Christine Zink
Janice E. Clements
Joseph L. Mankowski
Publication date: 01-04-2018
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 2/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0582-4

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An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

Abstract

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