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01-10-2017 | Case Report

Fatal ruxolitinib-related JC virus meningitis

Authors: Begoña Ballesta, Héctor González, Vicente Martín, Juan J. Ballesta

Published in: Journal of NeuroVirology | Issue 5/2017

Abstract

We report a possible association between ruxolitinib and JC virus meningitis. A 72-year-old man with myelofibrosis started treatment with ruxolitinib. Fourteen days later, the patient presented to the emergency department with fever and nausea. HIV test was negative. Ruxolitinib was suspended. Symptoms progressed with neck stiffness, cognitive impairment, and motor aphasia. CSF was positive for JC virus. MRI showed nonspecific abnormal findings. Five days after the clinical debut, the patient died. The clinical picture, MRI imaging, and positive JC virus PCR in CSF strongly suggest ruxolitinib-related JC virus meningitis.

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Title: Fatal ruxolitinib-related JC virus meningitis
Authors: Begoña Ballesta
Héctor González
Vicente Martín
Juan J. Ballesta
Publication date: 01-10-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 5/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0558-4

At a glance: The STEP trials

Springer Medicine

Fatal ruxolitinib-related JC virus meningitis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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