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01-10-2016 | Short Communication

Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia

Authors: Randall J. Cohrs, Hussain Badani, Nathan Bos, Charles Scianna, Ian Hoskins, Nicholas L. Baird, Don Gilden

Published in: Journal of NeuroVirology | Issue 5/2016

Abstract

Analysis of the frequency and PCR-quantifiable abundance of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) DNA in multiple biological replicates of cells from dissociated randomly distributed human trigeminal ganglia (TG) of four subjects revealed an increase in both parameters and in both viruses during 5 days of culture, with no further change by 10 days. Dissociated TG provides a platform to analyze initiation of latent virus DNA replication within 5 days of culture.

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Title: Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia
Authors: Randall J. Cohrs
Hussain Badani
Nathan Bos
Charles Scianna
Ian Hoskins
Nicholas L. Baird
Don Gilden
Publication date: 01-10-2016
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 5/2016
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0450-7

At a glance: The STEP trials

Springer Medicine

Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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