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01-10-2016

Interleukin-12 (-1188) A/C and interferon-γ (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients

Authors: Nihal Olgac Dundar, Pinar Gencpinar, Nilgun Sallakci, Ozgur Duman, Senay Haspolat, Banu Anlar, Olcay Yegin

Published in: Journal of NeuroVirology | Issue 5/2016

Abstract

The two polymorphisms [IL-12 (-1188) A/C and the IFN-γ (+874) A/T)] are known to have functional consequences and henceforth were analyzed in subacute sclerosing panencephalitis (SSPE) patients to reveal a possible relation with these polymorphisms and this debilitating disease. For the IL-12 (-1188) A/C polymorphism, 78 patients and 90 healthy individuals were analyzed. An increase in the AA genotype was determined (p = 0.02, OR = 2.06). There was also a statistically significant difference between the control group and the patients with respect to the allele frequencies (p = 0.04, OR = 1.65). For the IFN-γ (+874) A/T polymorphism, 69 SSPE patients and 115 controls were studied and there was not a significant difference between the two groups. Our findings suggested that not the IFN-γ (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with SSPE and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.

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Title: Interleukin-12 (-1188) A/C and interferon-γ (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients
Authors: Nihal Olgac Dundar
Pinar Gencpinar
Nilgun Sallakci
Ozgur Duman
Senay Haspolat
Banu Anlar
Olcay Yegin
Publication date: 01-10-2016
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 5/2016
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0442-7

At a glance: The STEP trials

Springer Medicine

Interleukin-12 (-1188) A/C and interferon-γ (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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