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01-02-2016

Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60

Authors: Anika Guha, Liang Wang, Aaron Tanenbaum, Pardis Esmaeili-Firidouni, Lauren A. Wendelken, Edgar Busovaca, Katherine Clifford, Akash Desai, Beau M. Ances, Victor Valcour

Published in: Journal of NeuroVirology | Issue 1/2016

Abstract

Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy (cART). Despite these advances, HIV-associated neurocognitive disorders (HAND) remain prevalent. In this study, we analyzed resting state functional connectivity (rs-fc) data from HIV-infected and matched HIV-uninfected adults aged 60 years and older to determine associations between HIV status, neuropsychological performance, and clinical variables. HIV-infected participants with detectable plasma HIV RNA exhibited decreased rs-fc within the salience (SAL) network compared to HIV-infected participants with suppressed plasma HIV RNA. We did not identify differences in rs-fc within HIV-infected individuals by HAND status. Our analysis identifies focal deficits in the SAL network that may be mitigated with suppression of plasma virus. However, these findings suggest that rs-fc may not be sensitive as a marker of HAND among individuals with suppressed plasma viral loads.

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Title: Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60
Authors: Anika Guha
Liang Wang
Aaron Tanenbaum
Pardis Esmaeili-Firidouni
Lauren A. Wendelken
Edgar Busovaca
Katherine Clifford
Akash Desai
Beau M. Ances
Victor Valcour
Publication date: 01-02-2016
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 1/2016
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-015-0370-y

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Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60

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