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01-06-2014 | Short Communication

T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus

Authors: Stephanie F. James, Vicki Traina-Dorge, Eileen Deharo, Mary Wellish, Brent E. Palmer, Don Gilden, Ravi Mahalingam

Published in: Journal of NeuroVirology | Issue 3/2014

Abstract

Like varicella zoster virus in humans, simian varicella virus (SVV) becomes latent in ganglionic neurons along the entire neuraxis and reactivates in immunosuppressed monkeys. Five rhesus macaques were inoculated with SVV; 142 days later (latency), four monkeys were immunosuppressed, and T cells were analyzed for naïve, memory, and effector phenotypes and expression of programmed death receptor-1 (PD-1; T cell exhaustion). All T cell subsets decreased during immunosuppression and except for CD8 effectors, peaked 2 weeks before zoster. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.

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Title: T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus
Authors: Stephanie F. James
Vicki Traina-Dorge
Eileen Deharo
Mary Wellish
Brent E. Palmer
Don Gilden
Ravi Mahalingam
Publication date: 01-06-2014
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 3/2014
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-014-0237-7

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T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus

Abstract

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