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Published in:

01-04-2011

Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection

Authors: Ann B. Ragin, Ying Wu, Renee Ochs, Hongyan Du, Leon G. Epstein, Katherine Conant, Justin C. McArthur

Published in: Journal of NeuroVirology | Issue 2/2011

Abstract

Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.

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Title: Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection
Authors: Ann B. Ragin
Ying Wu
Renee Ochs
Hongyan Du
Leon G. Epstein
Katherine Conant
Justin C. McArthur
Publication date: 01-04-2011
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 2/2011
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-011-0018-5

At a glance: The STEP trials

Springer Medicine

Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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