Top

European Journal of Drug Metabolism and Pharmacokinetics

Published in:

01-09-2011 | Original Paper

One-compartmental biometric blood loss calculation after cesarean section

Authors: Natasa Milosevic, Jovan Popovic, Zorica Grujic, Milan Rapaic

Published in: European Journal of Drug Metabolism and Pharmacokinetics | Issue 3/2011

Abstract

Blood loss during cesarean section was calculated based on post-operative decrement of hemoglobin (Hb) and hematocrit (Hct) level. The model used for pregnant women was previously validated for non-pregnant women who underwent gynecological surgery. 1,068 pregnant women who underwent cesarean section and 517 women who underwent gynecological surgery were included in the study. Regression lines between collected (x) and calculated (y) blood loss in pregnant women (y = 0.164 + 0.602x) and non-pregnant (y = 0.255 + 0.750x) women were statistically parallel. This study confirmed the applicability of one-compartmental model based on the drop in Hb levels for blood loss calculations for both gynecological surgery and cesarean section. Improved methods for calculating blood loss, V after cesarean section as V = [0.0115 × body weight (kg) × ln (preoperative Hb/postoperative Hb)] + [0.1905 × height³ (m) × ln (preoperative Hb/postoperative Hb)] + 0.3158 and after gynecological surgery V = [0.004 × body weight (kg) × ln (preoperative Hb/postoperative Hb)] + [0.4624 × height³ (m) × ln (preoperative Hb/postoperative Hb)] + 0.0472 were suggested.

Allen TH, Peng MT, Chen KP, Huang TF, Chang C, Fang HS (1956) Prediction of blood volume and adiposity in man from body weight and cube of height. Metabolism 5:328–345PubMed

Campbell CD (2000) Physiological changes of pregnancy. Semin Anesth 19(3):149–156. doi:10.1053/sa.2000.9038

Carlin A, Alfirevic Z (2008) Physiological changes of pregnancy and monitoring. Best Pract Res Clin Obstet Gynaecol 22(5):801–823. doi:10.1016/j.bpobgyn.2008.06.005 PubMedCrossRef

Flordal PA (1997) Measurement of blood loss in clinical studies. Eur J Anesth 14(14):35–37CrossRef

Fraser RB (2006) Obesity complicating pregnancy. Curr Obstet Gynaecol 16:295–298. doi:10.1016/j.curobgyn.2006.07.005 CrossRef

Kavle JA, Khalfan SS, Stoltzfus RJ, Witter F, Tielsch JM, Caulfield LE (2006) Measurement of blood loss at childbirth and postpartum. Int J Gynecol Obstet 95:24–28. doi:10.1016/j.ijgo.2006.06.010 CrossRef

Kuhn KS, Wojdyla D, Say L, Gulmezoglu AM, VanLook PFA (2006) WHO analysis of causes of maternal death: a systematic review. Lancet 367:1066–1074CrossRef

Lyon M, Blaivas M, Brannam L (2005) Sonographic measurement of the inferior vena cava as a maker of blood loss. Am J Emerg Med 23:45–50PubMedCrossRef

Murphy DJ, MacGregor H, Munishankar B, McLeod G (2009) A randomised controlled trial of oxytocin 5 IU and placebo infusion versus oxytocin 5 IU and 30 IU infusion for the control of blood loss at elective cesarean section—Pilot study. Eur J Obstet Gynecol Reprod Biol 142:30–33. doi:10.1016/j.ejogrb.2008.09.004 PubMedCrossRef

Nadler SB, Hidalgo JU, Bloch T (1962) Prediction of blood volume in normal human adults. Surgery 51:224–232

Popovic J, Grujic Z (2008) Influence of pregnancy on one-compartmental bio-metric blood loss calculations after cesarean section and gynecological surgery. Eur J Drug Metab Pharmacokinet 33(1):53–59PubMedCrossRef

Rains AJH (1955) Experience in the measurement of blood- and fluid-loss at operation. Br J Surg 43:191–196PubMedCrossRef

Read MD, Andeton JM (1977) Radioisotope dilution technique for measurement of blood loss associated with lower segment cesarean section. Br J Obstet Gynaecol 84:859–861PubMedCrossRef

Schorn NM (2010) Measurment of blood loss: review of the literature. J Midwifery Womens Health 55(1):20–27. doi:10.1016/j.jmwh.2009.02.014 PubMedCrossRef

Stafford I, Dildy GA, Clark SL, Belford MA (2008) Visually estimated and calculated blood loss in vaginal and cesarean delivery. Am J Obstet Gynecol 199:519 e1–519 e7

Thornton JA (1963) Estimation of blood loss during surgery. Ann R Coll Surg Engl 33(3):164–174PubMed

Wu WC, Hsieh CH, Huang LC, Chang YY, Hung YC, Chang WC (2009) Surgical blood loss and laparascopic-assisted vaginal hysterectomy. Taiwan J Obstet Gynecol 48(4):400–402PubMedCrossRef

Title: One-compartmental biometric blood loss calculation after cesarean section
Authors: Natasa Milosevic
Jovan Popovic
Zorica Grujic
Milan Rapaic
Publication date: 01-09-2011
Publisher: Springer-Verlag
Published in: European Journal of Drug Metabolism and Pharmacokinetics / Issue 3/2011
Print ISSN: 0378-7966
Electronic ISSN: 2107-0180
DOI: https://doi.org/10.1007/s13318-011-0042-0

At a glance: The STEP trials

Springer Medicine

One-compartmental biometric blood loss calculation after cesarean section

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2011

Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis

Renal excretion of apricitabine in rats: ex vivo and in vivo studies

Explicit reformulations of the Lambert W-omega function for calculations of the solutions to one-compartment pharmacokinetic models with Michaelis–Menten elimination kinetics

Effects of myricetin, an anticancer compound, on the bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats

In vitro characterization of rosiglitazone metabolites and determination of the kinetic parameters employing rat liver microsomal fraction

Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum