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Published in:

01-01-2011

MRI in Rodent Models of Brain Disorders

Authors: Aleksandar Denic, Slobodan I. Macura, Prasanna Mishra, Jeffrey D. Gamez, Moses Rodriguez, Istvan Pirko

Published in: Neurotherapeutics | Issue 1/2011

Summary

Magnetic resonance imaging (MRI) is a well-established tool in clinical practice and research on human neurological disorders. Translational MRI research utilizing rodent models of central nervous system (CNS) diseases is becoming popular with the increased availability of dedicated small animal MRI systems. Projects utilizing this technology typically fall into one of two categories: 1) true “pre-clinical” studies involving the use of MRI as a noninvasive disease monitoring tool which serves as a biomarker for selected aspects of the disease and 2) studies investigating the pathomechanism of known human MRI findings in CNS disease models. Most small animal MRI systems operate at 4.7–11.7 Tesla field strengths. Although the higher field strength clearly results in a higher signal-to-noise ratio, which enables higher resolution acquisition, a variety of artifacts and limitations related to the specific absorption rate represent significant challenges in these experiments. In addition to standard T1-, T2-, and T2*-weighted MRI methods, all of the currently available advanced MRI techniques have been utilized in experimental animals, including diffusion, perfusion, and susceptibility weighted imaging, functional magnetic resonance imaging, chemical shift imaging, heteronuclear imaging, and ¹H or ³¹P MR spectroscopy. Selected MRI techniques are also exclusively utilized in experimental research, including manganese-enhanced MRI, and cell-specific/molecular imaging techniques utilizing negative contrast materials. In this review, we describe technical and practical aspects of small animal MRI and provide examples of different MRI techniques in anatomical imaging and tract tracing as well as several models of neurological disorders, including inflammatory, neurodegenerative, vascular, and traumatic brain and spinal cord injury models, and neoplastic diseases.

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Title: MRI in Rodent Models of Brain Disorders
Authors: Aleksandar Denic
Slobodan I. Macura
Prasanna Mishra
Jeffrey D. Gamez
Moses Rodriguez
Istvan Pirko
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Neurotherapeutics / Issue 1/2011
Print ISSN: 1933-7213
Electronic ISSN: 1878-7479
DOI: https://doi.org/10.1007/s13311-010-0002-4

At a glance: The STEP trials

Springer Medicine

MRI in Rodent Models of Brain Disorders

Summary

At a glance: The STEP trials

Springer Medicine

Summary

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