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Updates in Surgery
Published in: Updates in Surgery 4/2021

01-08-2021 | Pancreatectomy | Review Article

Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy

Authors: Francesca Aleotti, Rita Nano, Lorenzo Piemonti, Massimo Falconi, Gianpaolo Balzano

Published in: Updates in Surgery | Issue 4/2021

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Abstract

Total pancreatectomy (TP) is a procedure weighed down not only by postoperative morbidity and mortality but also by long-term effects as a consequence of endocrine and exocrine pancreatic insufficiency. While the latter is now managed quite effectively with pancreatic enzyme replacement therapy, the former remains a challenge. The diabetes resulting after TP, with the complete loss of endogenous insulin and contraregulatory hormones, is characterized by important glycemic variations and is, therefore, frequently referred to as “brittle diabetes”. One method to reduce the impact of brittle diabetes in patients undergoing TP is the re-infusion of autologous pancreatic islets isolated from the resected pancreas. Indications to islet autotransplantation (IAT), originally described for patients undergoing TP for chronic pancreatitis, have since been extended to selected patients with other benign and malignant diseases of pancreas. This review recaps on the literature regarding long-term postoperative complications, their impact on quality of life after TP and the role of IAT.
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Metadata
Title
Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy
Authors
Francesca Aleotti
Rita Nano
Lorenzo Piemonti
Massimo Falconi
Gianpaolo Balzano
Publication date
01-08-2021
Publisher
Springer International Publishing
Published in
Updates in Surgery / Issue 4/2021
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-021-01129-w

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