Skip to main content
Top
Published in: Updates in Surgery 1/2021

01-02-2021 | Crohn's Disease | Original Article

Anastomosis configuration and technique following ileocaecal resection for Crohn’s disease: a multicentre study

Authors: Valerio Celentano, Gianluca Pellino, Antonino Spinelli, Francesco Selvaggi, Valerio Celentano, Gianluca Pellino, Matteo Rottoli, Gilberto Poggioli, Giuseppe Sica, Mariano Cesare Giglio, Michela Campanelli, Claudio Coco, Gianluca Rizzo, Francesco Sionne, Francesco Colombo, Gianluca Sampietro, Giulia Lamperti, Diego Foschi, Ferdinando Ficari, Ludovica Vacca, Marta Cricchio, Francesco Giudici, Lucio Selvaggi, Guido Sciaudone, Roberto Peltrini, Andrea Manfreda, Luigi Bucci, Raffaele Galleano, Omar Ghazouani, Luigi Zorcolo, Simona Deidda, Angelo Restivo, Andrea Braini, Francesca Di Candido, Matteo Sacchi, Michele Carvello, Stefania Martorana, Giovanni Bordignon, Imerio Angriman, Angela Variola, Mirko Di Ruscio, Giuliano Barugola, Andrea Geccherle, Francesca Paola Tropeano, Gaetano Luglio, Marta Tanzanu, Diego Sasia, Marco Migliore, Maria Carmela Giuffrida, Enrico Marrano, Gianluigi Moretto, Harmony Impellizzeri, Gaetano Gallo, Giuseppina Vescio, Giuseppe Sammarco, Giovanni Terrosu, Giacomo Calini, Andrea Bondurri, Anna Maffioli, Gloria Zaffaroni, Andrea Resegotti, Massimiliano Mistrangelo, Marco Ettore Allaix, Fiorenzo Botti, Matteo Prati, Luigi Boni, Serena Perotti, Michela Mineccia, Antonio Giuliani, Lucia Romano, Giorgio Maria Paolo Graziano, Luigi Pugliese, Andrea Pietrabissa, GianGaetano Delaini, Antonino Spinelli, Francesco Selvaggi, SICCR Current status of Crohn’s disease surgery collaborative, , on behalf of the Italian Society of Colorectal Surgery SICCR

Published in: Updates in Surgery | Issue 1/2021

Login to get access

Abstract

A limited ileocaecal resection is the most frequently performed procedure for ileocaecal CD and different anastomotic configurations and techniques have been described. This manuscript audited the different anastomotic techniques used in a national study and evaluated their influence on postoperative outcomes following ileocaecal resection for primary CD. This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing elective ileocaecal resection for primary CD from June 2018 May 2019. Postoperative morbidity within 30 days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. 427 patients were included. The side to side anastomosis was the chosen configuration in 380 patients (89%). The stapled anastomotic (n = 286; 67%), techniques were preferred to hand-sewn (n = 141; 33%). Postoperative morbidity was 20.3% and anastomotic leak 3.7%. Anastomotic leak was independent of the type of anastomosis performed, while was associated with an ASA grade ≥ 3, presence of perianal disease and ileocolonic localization of disease. Four predictors of LOS were identified after multivariate analysis. The laparoscopic approach was the only associated with a reduced LOS (p = 0.017), while age, ASA grade ≥ 3 or administration of preoperative TPN were associated with increased LOS. The side to side was the most commonly used anastomotic configuration for ileocolic reconstruction following primary CD resection. There was no difference in postoperative morbidity according to anastomotic technique and configuration. Anastomotic leak was associated with ASA grade ≥ 3, a penetrating phenotype of disease and ileo-colonic distribution of CD.
Appendix
Available only for authorised users
Literature
1.
go back to reference Pellino G, Keller DS, Sampietro GM, Angriman I, Carvello M, Celentano V, Colombo F, Di Candido F, Laureti S, Luglio G, Poggioli G, Rottoli M, Scaringi S, Sciaudone G, Sica G, Sofo L, Leone S, Danese S, Spinelli A, Delaini G, Selvaggi F, Italian Society of Colorectal Surgery SICCR (2020) Inflammatory bowel disease position statement of the Italian society of colorectal surgery (SICCR): Crohn’s disease. Tech Coloproctol. https://doi.org/10.1007/s10151-020-02183-z ([Epub ahead of print] Review)CrossRefPubMed Pellino G, Keller DS, Sampietro GM, Angriman I, Carvello M, Celentano V, Colombo F, Di Candido F, Laureti S, Luglio G, Poggioli G, Rottoli M, Scaringi S, Sciaudone G, Sica G, Sofo L, Leone S, Danese S, Spinelli A, Delaini G, Selvaggi F, Italian Society of Colorectal Surgery SICCR (2020) Inflammatory bowel disease position statement of the Italian society of colorectal surgery (SICCR): Crohn’s disease. Tech Coloproctol. https://​doi.​org/​10.​1007/​s10151-020-02183-z ([Epub ahead of print] Review)CrossRefPubMed
3.
go back to reference Bemelman WA, Warusavitarne J, Sampietro GM, Serclova Z, Zmora O, Luglio G, de van BuckOverstraeten A, Burke JP, Buskens CJ, Colombo F, Dias JA, Eliakim R, Elosua T, Gecim IE, Kolacek S, Kierkus J, Kolho KL, Lefevre JH, Millan M, Panis Y, Pinkney T, Russell RK, Shwaartz C, Vaizey C, Yassin N, D’Hoore A (2018) ECCO-ESCP consensus on surgery for Crohn’s Disease. J Crohns Colitis 12(1):1–16. https://doi.org/10.1093/ecco-jcc/jjx061CrossRefPubMed Bemelman WA, Warusavitarne J, Sampietro GM, Serclova Z, Zmora O, Luglio G, de van BuckOverstraeten A, Burke JP, Buskens CJ, Colombo F, Dias JA, Eliakim R, Elosua T, Gecim IE, Kolacek S, Kierkus J, Kolho KL, Lefevre JH, Millan M, Panis Y, Pinkney T, Russell RK, Shwaartz C, Vaizey C, Yassin N, D’Hoore A (2018) ECCO-ESCP consensus on surgery for Crohn’s Disease. J Crohns Colitis 12(1):1–16. https://​doi.​org/​10.​1093/​ecco-jcc/​jjx061CrossRefPubMed
4.
go back to reference Ghoneima AS, Flashman K, Dawe V, Baldwin E, Celentano V (2019) High risk of septic complications following surgery for Crohn’s disease in patients with preoperative anaemia, hypoalbuminemia and high CRP. Int J Colorectal Dis 34(12):2185–2188CrossRef Ghoneima AS, Flashman K, Dawe V, Baldwin E, Celentano V (2019) High risk of septic complications following surgery for Crohn’s disease in patients with preoperative anaemia, hypoalbuminemia and high CRP. Int J Colorectal Dis 34(12):2185–2188CrossRef
5.
go back to reference Rosenfeld G, Qian H, Bressler B (2013) The risks of post-operative complications following pre-operative infliximab therapy for Crohn’s disease in patients undergoing abdominal surgery: a systematic review and meta-analysis. J Crohns Colitis 7(11):868–877CrossRef Rosenfeld G, Qian H, Bressler B (2013) The risks of post-operative complications following pre-operative infliximab therapy for Crohn’s disease in patients undergoing abdominal surgery: a systematic review and meta-analysis. J Crohns Colitis 7(11):868–877CrossRef
6.
go back to reference Uchino M, Ikeuchi H, Bando T et al (2012) Risk factors for short bowel syndrome in patients with Crohn’s disease. Surg Today 42(5):447–452CrossRef Uchino M, Ikeuchi H, Bando T et al (2012) Risk factors for short bowel syndrome in patients with Crohn’s disease. Surg Today 42(5):447–452CrossRef
7.
go back to reference Celentano V, O’Leary DP, Caiazzo A, Flashman KG, Sagias F, Conti J, Senapati A, Khan J (2019) Longer small bowel segments are resected in emergency surgery for ileocaecal Crohn’s disease with a higher ileostomy and complication rate. Tech Coloproctol 23(11):1085–1091CrossRef Celentano V, O’Leary DP, Caiazzo A, Flashman KG, Sagias F, Conti J, Senapati A, Khan J (2019) Longer small bowel segments are resected in emergency surgery for ileocaecal Crohn’s disease with a higher ileostomy and complication rate. Tech Coloproctol 23(11):1085–1091CrossRef
9.
go back to reference von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, STROBE Initiative (2008) The strengthening the reporting of observational studies in epidemiology (STROBE)statement: guidelines for reporting observational studies. J Clin Epidemiol 61(4):344–349CrossRef von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, STROBE Initiative (2008) The strengthening the reporting of observational studies in epidemiology (STROBE)statement: guidelines for reporting observational studies. J Clin Epidemiol 61(4):344–349CrossRef
10.
go back to reference European society of coloproctology collaborating group (2017) Risk factors for unfavourable postoperative outcome in patients with Crohn’s disease undergoing right hemicolectomy or ileocaecal resection an international audit by ESCP and S-ECCO. Colorectal Dis. https://doi.org/10.1111/codi.13889 (Epub ahead of print)CrossRef European society of coloproctology collaborating group (2017) Risk factors for unfavourable postoperative outcome in patients with Crohn’s disease undergoing right hemicolectomy or ileocaecal resection an international audit by ESCP and S-ECCO. Colorectal Dis. https://​doi.​org/​10.​1111/​codi.​13889 (Epub ahead of print)CrossRef
11.
go back to reference Johnston WF, Stafford C, Francone TD, Read TE, Marcello PW, Roberts PL, Ricciardi R (2017) What Is the risk of anastomotic leak after repeat intestinal resection in patients with Crohn’s disease? Dis Colon Rectum 60(12):1299–1306CrossRef Johnston WF, Stafford C, Francone TD, Read TE, Marcello PW, Roberts PL, Ricciardi R (2017) What Is the risk of anastomotic leak after repeat intestinal resection in patients with Crohn’s disease? Dis Colon Rectum 60(12):1299–1306CrossRef
12.
go back to reference Adamina M, Bonovas S, Raine T, Spinelli A, Warusavitarne J, Armuzzi A, Bachmann O, Bager P, Biancone L, Bokemeyer B, Bossuyt P, Burisch J, Collins P, Doherty G, El-Hussuna A, Ellul P, Fiorino G, Frei-Lanter C, Furfaro F, Gingert C, Gionchetti P, Gisbert JP, Gomollon F, González Lorenzo M, Gordon H, Hlavaty T, Juillerat P, Katsanos K, Kopylov U, Krustins E, Kucharzik T, Lytras T, Maaser C, Magro F, Marshall JK, Myrelid P, Pellino G, Rosa I, Sabino J, Savarino E, Stassen L, Torres J, Uzzan M, Vavricka S, Verstockt B, Zmora O (2020) ECCO guidelines on therapeutics in Crohn’s disease: surgical treatment. J Crohns Colitis 14(2):155–168. https://doi.org/10.1093/ecco-jcc/jjz187CrossRefPubMed Adamina M, Bonovas S, Raine T, Spinelli A, Warusavitarne J, Armuzzi A, Bachmann O, Bager P, Biancone L, Bokemeyer B, Bossuyt P, Burisch J, Collins P, Doherty G, El-Hussuna A, Ellul P, Fiorino G, Frei-Lanter C, Furfaro F, Gingert C, Gionchetti P, Gisbert JP, Gomollon F, González Lorenzo M, Gordon H, Hlavaty T, Juillerat P, Katsanos K, Kopylov U, Krustins E, Kucharzik T, Lytras T, Maaser C, Magro F, Marshall JK, Myrelid P, Pellino G, Rosa I, Sabino J, Savarino E, Stassen L, Torres J, Uzzan M, Vavricka S, Verstockt B, Zmora O (2020) ECCO guidelines on therapeutics in Crohn’s disease: surgical treatment. J Crohns Colitis 14(2):155–168. https://​doi.​org/​10.​1093/​ecco-jcc/​jjz187CrossRefPubMed
13.
go back to reference Gajendran M, Bauer AJ, Buchholz BM, Watson AR, Koutroubakis IE, Hashash JG, Ramos-Rivers C, Shah N, Lee KK, Cruz RJ, Regueiro M, Zuckerbraun B, Schwartz M, Swoger J, Barrie A, Harrison J, Hartman DJ, Salgado J, Rivers WM, Click B, Anderson AM, Umapathy C, Babichenko D, Dunn MA, Binion DG (2018) Ileocecal anastomosis type significantly influences long-term functional status, quality of life, and healthcare utilization in postoperative Crohn’s disease patients independent of inflammation recurrence. Am J Gastroenterol 113(4):576–583. https://doi.org/10.1038/ajg.2018.13 (Epub 2018 Mar 6)CrossRefPubMed Gajendran M, Bauer AJ, Buchholz BM, Watson AR, Koutroubakis IE, Hashash JG, Ramos-Rivers C, Shah N, Lee KK, Cruz RJ, Regueiro M, Zuckerbraun B, Schwartz M, Swoger J, Barrie A, Harrison J, Hartman DJ, Salgado J, Rivers WM, Click B, Anderson AM, Umapathy C, Babichenko D, Dunn MA, Binion DG (2018) Ileocecal anastomosis type significantly influences long-term functional status, quality of life, and healthcare utilization in postoperative Crohn’s disease patients independent of inflammation recurrence. Am J Gastroenterol 113(4):576–583. https://​doi.​org/​10.​1038/​ajg.​2018.​13 (Epub 2018 Mar 6)CrossRefPubMed
14.
go back to reference Kano M, Hanari N, Gunji H, Hayano K, Hayashi H, Matsubara H (2017) Is, “functional end-to-end anastomosis” really functional? A review of the literature on stapled anastomosis using linear staplers. Surg Today 47(1):1–7 (Epub 2016 Mar 17)CrossRef Kano M, Hanari N, Gunji H, Hayano K, Hayashi H, Matsubara H (2017) Is, “functional end-to-end anastomosis” really functional? A review of the literature on stapled anastomosis using linear staplers. Surg Today 47(1):1–7 (Epub 2016 Mar 17)CrossRef
15.
go back to reference de van BuckOverstraeten A, Eshuis EJ, Vermeire S, Van Assche G, Ferrante M, D’Haens GR, Ponsioen CY, Belmans A, Buskens CJ, Wolthuis AM, Bemelman WA, D’Hoore A (2017) Short- and medium-term outcomes following primary ileocaecal resection for Crohn’s disease in two specialist centres. Br J Surg 104(12):1713–1722. https://doi.org/10.1002/bjs.10595 (Epub 2017 Jul 26)CrossRef de van BuckOverstraeten A, Eshuis EJ, Vermeire S, Van Assche G, Ferrante M, D’Haens GR, Ponsioen CY, Belmans A, Buskens CJ, Wolthuis AM, Bemelman WA, D’Hoore A (2017) Short- and medium-term outcomes following primary ileocaecal resection for Crohn’s disease in two specialist centres. Br J Surg 104(12):1713–1722. https://​doi.​org/​10.​1002/​bjs.​10595 (Epub 2017 Jul 26)CrossRef
17.
go back to reference Garofalo E, Lucarini A, Flashman KG, Celentano V (2019) A positive proximal resection margin is associated with anastomotic complications following primary ileocaecal resection for Crohn’s disease. Int J Colorectal Dis 34(9):1585–1590CrossRef Garofalo E, Lucarini A, Flashman KG, Celentano V (2019) A positive proximal resection margin is associated with anastomotic complications following primary ileocaecal resection for Crohn’s disease. Int J Colorectal Dis 34(9):1585–1590CrossRef
18.
go back to reference Coffey CJ, Kiernan MG, Sahebally SM, Jarrar A, Burke JP, Kiely PA, Shen B, Waldron D, Peirce C, Moloney M, Skelly M, Tibbitts P, Hidayat H, Faul PN, Healy V, O’Leary PD, Walsh LG, Dockery P, O’Connell RP, Martin ST, Shanahan F, Fiocchi C, Dunne CP (2018) Inclusion of the mesentery in ileocolic resection for Crohn’s disease is associated with reduced surgical recurrence. J Crohns Colitis 12(10):1139–1150CrossRef Coffey CJ, Kiernan MG, Sahebally SM, Jarrar A, Burke JP, Kiely PA, Shen B, Waldron D, Peirce C, Moloney M, Skelly M, Tibbitts P, Hidayat H, Faul PN, Healy V, O’Leary PD, Walsh LG, Dockery P, O’Connell RP, Martin ST, Shanahan F, Fiocchi C, Dunne CP (2018) Inclusion of the mesentery in ileocolic resection for Crohn’s disease is associated with reduced surgical recurrence. J Crohns Colitis 12(10):1139–1150CrossRef
19.
go back to reference Buskens CJ, de Groof EJ, Bemelman WA, Wildenberg ME (2017) The role of the mesentery in Crohn’s disease. Lancet Gastroenterol Hepatol 2(4):245–246CrossRef Buskens CJ, de Groof EJ, Bemelman WA, Wildenberg ME (2017) The role of the mesentery in Crohn’s disease. Lancet Gastroenterol Hepatol 2(4):245–246CrossRef
Metadata
Title
Anastomosis configuration and technique following ileocaecal resection for Crohn’s disease: a multicentre study
Authors
Valerio Celentano
Gianluca Pellino
Antonino Spinelli
Francesco Selvaggi
Valerio Celentano
Gianluca Pellino
Matteo Rottoli
Gilberto Poggioli
Giuseppe Sica
Mariano Cesare Giglio
Michela Campanelli
Claudio Coco
Gianluca Rizzo
Francesco Sionne
Francesco Colombo
Gianluca Sampietro
Giulia Lamperti
Diego Foschi
Ferdinando Ficari
Ludovica Vacca
Marta Cricchio
Francesco Giudici
Lucio Selvaggi
Guido Sciaudone
Roberto Peltrini
Andrea Manfreda
Luigi Bucci
Raffaele Galleano
Omar Ghazouani
Luigi Zorcolo
Simona Deidda
Angelo Restivo
Andrea Braini
Francesca Di Candido
Matteo Sacchi
Michele Carvello
Stefania Martorana
Giovanni Bordignon
Imerio Angriman
Angela Variola
Mirko Di Ruscio
Giuliano Barugola
Andrea Geccherle
Francesca Paola Tropeano
Gaetano Luglio
Marta Tanzanu
Diego Sasia
Marco Migliore
Maria Carmela Giuffrida
Enrico Marrano
Gianluigi Moretto
Harmony Impellizzeri
Gaetano Gallo
Giuseppina Vescio
Giuseppe Sammarco
Giovanni Terrosu
Giacomo Calini
Andrea Bondurri
Anna Maffioli
Gloria Zaffaroni
Andrea Resegotti
Massimiliano Mistrangelo
Marco Ettore Allaix
Fiorenzo Botti
Matteo Prati
Luigi Boni
Serena Perotti
Michela Mineccia
Antonio Giuliani
Lucia Romano
Giorgio Maria Paolo Graziano
Luigi Pugliese
Andrea Pietrabissa
GianGaetano Delaini
Antonino Spinelli
Francesco Selvaggi
SICCR Current status of Crohn’s disease surgery collaborative
, on behalf of the Italian Society of Colorectal Surgery SICCR
Publication date
01-02-2021
Publisher
Springer International Publishing
Keyword
Crohn's Disease
Published in
Updates in Surgery / Issue 1/2021
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-020-00918-z

Other articles of this Issue 1/2021

Updates in Surgery 1/2021 Go to the issue